TNAA_PASMU
ID TNAA_PASMU Reviewed; 471 AA.
AC Q9CL27;
DT 27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 120.
DE RecName: Full=Tryptophanase;
DE EC=4.1.99.1;
DE AltName: Full=L-tryptophan indole-lyase;
DE Short=TNase;
GN Name=tnaA; OrderedLocusNames=PM1420;
OS Pasteurella multocida (strain Pm70).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Pasteurella.
OX NCBI_TaxID=272843;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pm70;
RX PubMed=11248100; DOI=10.1073/pnas.051634598;
RA May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V.;
RT "Complete genomic sequence of Pasteurella multocida Pm70.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-tryptophan = indole + NH4(+) + pyruvate;
CC Xref=Rhea:RHEA:19553, ChEBI:CHEBI:15361, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:16881, ChEBI:CHEBI:28938, ChEBI:CHEBI:57912; EC=4.1.99.1;
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000250};
CC -!- PATHWAY: Amino-acid degradation; L-tryptophan degradation via pyruvate
CC pathway; indole and pyruvate from L-tryptophan: step 1/1.
CC -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the beta-eliminating lyase family.
CC {ECO:0000305}.
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DR EMBL; AE004439; AAK03504.1; -; Genomic_DNA.
DR RefSeq; WP_005754976.1; NC_002663.1.
DR AlphaFoldDB; Q9CL27; -.
DR SMR; Q9CL27; -.
DR STRING; 747.DR93_274; -.
DR PRIDE; Q9CL27; -.
DR EnsemblBacteria; AAK03504; AAK03504; PM1420.
DR KEGG; pmu:PM1420; -.
DR HOGENOM; CLU_047223_0_0_6; -.
DR OMA; EMYQYGD; -.
DR UniPathway; UPA00332; UER00452.
DR Proteomes; UP000000809; Chromosome.
DR GO; GO:0009034; F:tryptophanase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.640.10; -; 1.
DR Gene3D; 3.90.1150.10; -; 1.
DR HAMAP; MF_00544; Tryptophanase; 1.
DR InterPro; IPR001597; ArAA_b-elim_lyase/Thr_aldolase.
DR InterPro; IPR011166; Beta-eliminating_lyase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR InterPro; IPR013440; TNase.
DR InterPro; IPR018176; Tryptophanase_CS.
DR Pfam; PF01212; Beta_elim_lyase; 1.
DR PIRSF; PIRSF001386; Trpase; 1.
DR SUPFAM; SSF53383; SSF53383; 1.
DR TIGRFAMs; TIGR02617; tnaA_trp_ase; 1.
DR PROSITE; PS00853; BETA_ELIM_LYASE; 1.
PE 3: Inferred from homology;
KW Lyase; Pyridoxal phosphate; Reference proteome; Tryptophan catabolism.
FT CHAIN 1..471
FT /note="Tryptophanase"
FT /id="PRO_0000195616"
FT MOD_RES 270
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 471 AA; 52893 MW; B6DE142FF1A7BF8E CRC64;
MENFKHLPEP FRIRVIEPVR RTTRSYREEA ILKAGMNPFL LDSEDVFIDL LTDSGTGAVT
QEMQAAMLRG DEAYSGSRSY HALANAVKEI FGYEYTIPTH QGRGAEQIYI PVLIKKREQE
KGLDRSKMVV FSNYFFDTTQ GHSQINGATV RNVYTKEAFD TSVNADFKGD FDLEKLEQGI
QEVGAENVPY IVCTITCNSA GGQPVSLANM RAMYEIAKKY DIPVVMDSAR FAENAYFIQQ
REPGYKEWTI EQITYESYKY ADALAMSAKK DAMVPMGGLL CFKDKSMEDV YNECRTLCVV
QEGFPTYGGL EGGAMERLAV GLRDGMRQDW LAYRINQIEY LVNGLEAIGV VCQQPGGHAA
FVDAGKLLPH IPADQFPAQA LACELYKVAG IRAVEIGSFL LGRDPKTGKQ LPCPAELLRL
TIPRATYTQT HMDFIIEAFK QVKENAENIK GLTFTYEPKV LRHFTARLKE V