ID   TNAB_PROVU              Reviewed;         417 AA.
AC   P28785;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Low affinity tryptophan permease;
GN   Name=tnaB; Synonyms=trpP;
OS   Proteus vulgaris.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Proteus.
OX   NCBI_TaxID=585;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1400314; DOI=10.1016/s0021-9258(19)88653-2;
RA   Kamath A.V., Yanofsky C.;
RT   "Characterization of the tryptophanase operon of Proteus vulgaris. Cloning,
RT   nucleotide sequence, amino acid homology, and in vitro synthesis of the
RT   leader peptide and regulatory analysis.";
RL   J. Biol. Chem. 267:19978-19985(1992).
CC   -!- FUNCTION: Involved in tryptophan transport across the cytoplasmic
CC       membrane. Plays a role in transporting tryptophan which is to be used
CC       catabolically.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC   -!- INDUCTION: By tryptophan. Is subject to catabolic repression.
CC   -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC       Mtr/TnaB/TyrP permease subfamily. {ECO:0000305}.
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DR   EMBL; M93277; AAA25665.1; -; Genomic_DNA.
DR   PIR; C44038; C44038.
DR   AlphaFoldDB; P28785; -.
DR   SMR; P28785; -.
DR   STRING; 585.DR95_2913; -.
DR   eggNOG; COG0814; Bacteria.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0015173; F:aromatic amino acid transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006569; P:tryptophan catabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR018227; Amino_acid_transport_2.
DR   InterPro; IPR013061; Trp/try_permease_CS.
DR   InterPro; IPR013059; Trp_tyr_transpt.
DR   PANTHER; PTHR46997; PTHR46997; 1.
DR   Pfam; PF03222; Trp_Tyr_perm; 1.
DR   PRINTS; PR00166; AROAAPRMEASE.
DR   TIGRFAMs; TIGR00837; araaP; 1.
DR   PROSITE; PS00594; AROMATIC_AA_PERMEASE_1; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW   Transmembrane; Transmembrane helix; Transport; Tryptophan catabolism.
FT   CHAIN           1..417
FT                   /note="Low affinity tryptophan permease"
FT                   /id="PRO_0000093802"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        152..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        288..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        325..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        346..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        383..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   417 AA;  46273 MW;  9EA4E61E6AE8CAE1 CRC64;
     MENTSVNKEP SIIVGGFVLG GAMIGAGMFS LPTIMSGAWF INSLFILFIV CFFMFHSGIY
     ILECISKYGA GTNYFDISKE LLPKWACYIA NASLIFVLYI LIYAYISAAG SIIYEASLLY
     GINFNLRAIF FIFTIALGAT IWWGGACASR LTSIFLFIKI VLFILAFSGL FFKAKGDLLF
     SATFAGKSQL YLYPFIFIII PYAITSFGYH GNVCSLYKLY NQNERKVVKS CIIGCLLALV
     IYLLWMIGTM GNLPREQFIT IIQKGGNLDA FIDSLYTVLN SKYIEGFLLW FSISAVFCSF
     LGVAIGLFDY ILASLKFKDN KTGRLKSGVL CFTPPLLLCL FFPNGFLIAI AYAGTAACVW
     AIICPAVMAL KARQKFPNSG FKVWGGKKLI YAVIAFGVVG IICQSWRNLI YCLFIVK