TNAP2_HUMAN
ID TNAP2_HUMAN Reviewed; 654 AA.
AC Q03169; Q86VI0;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2006, sequence version 2.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Tumor necrosis factor alpha-induced protein 2;
DE Short=TNF alpha-induced protein 2;
DE AltName: Full=Primary response gene B94 protein;
GN Name=TNFAIP2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT GLU-282.
RC TISSUE=Umbilical vein endothelial cell;
RX PubMed=1374453;
RA Sarma V., Wolf F.W., Marks R.M., Shows T.B., Dixit V.M.;
RT "Cloning of a novel tumor necrosis factor-alpha-inducible primary response
RT gene that is differentially expressed in development and capillary tube-
RT like formation in vitro.";
RL J. Immunol. 148:3302-3312(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ALA-110 INS; GLU-282;
RP ILE-565 AND MET-580.
RG SeattleSNPs variation discovery resource;
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role as a mediator of inflammation and
CC angiogenesis.
CC -!- INTERACTION:
CC Q03169; O75604: USP2; NbExp=3; IntAct=EBI-7954198, EBI-743272;
CC -!- DEVELOPMENTAL STAGE: Differentially expressed in development and
CC capillary tube-like formation in vitro.
CC -!- INDUCTION: By TNF and other pro-inflammatory factors.
CC -!- SIMILARITY: Belongs to the SEC6 family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=SeattleSNPs;
CC URL="http://pga.gs.washington.edu/data/tnfaip2/";
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DR EMBL; M92357; AAA35582.1; -; mRNA.
DR EMBL; AL161669; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY273786; AAP12649.1; -; Genomic_DNA.
DR CCDS; CCDS9979.1; -.
DR PIR; I56134; I56134.
DR RefSeq; NP_006282.2; NM_006291.2.
DR RefSeq; XP_011535416.1; XM_011537114.2.
DR AlphaFoldDB; Q03169; -.
DR SMR; Q03169; -.
DR BioGRID; 112982; 60.
DR IntAct; Q03169; 6.
DR MINT; Q03169; -.
DR STRING; 9606.ENSP00000452634; -.
DR TCDB; 1.L.1.1.1; the tunneling nanotube (tnt) family.
DR iPTMnet; Q03169; -.
DR PhosphoSitePlus; Q03169; -.
DR SwissPalm; Q03169; -.
DR BioMuta; TNFAIP2; -.
DR DMDM; 93141326; -.
DR EPD; Q03169; -.
DR jPOST; Q03169; -.
DR MassIVE; Q03169; -.
DR MaxQB; Q03169; -.
DR PaxDb; Q03169; -.
DR PeptideAtlas; Q03169; -.
DR PRIDE; Q03169; -.
DR ProteomicsDB; 58199; -.
DR Antibodypedia; 3892; 206 antibodies from 31 providers.
DR DNASU; 7127; -.
DR Ensembl; ENST00000333007.8; ENSP00000332326.1; ENSG00000185215.11.
DR Ensembl; ENST00000560869.6; ENSP00000452634.2; ENSG00000185215.11.
DR GeneID; 7127; -.
DR KEGG; hsa:7127; -.
DR MANE-Select; ENST00000560869.6; ENSP00000452634.2; NM_006291.4; NP_006282.2.
DR UCSC; uc001ymm.1; human.
DR CTD; 7127; -.
DR DisGeNET; 7127; -.
DR GeneCards; TNFAIP2; -.
DR HGNC; HGNC:11895; TNFAIP2.
DR HPA; ENSG00000185215; Tissue enhanced (urinary).
DR MIM; 603300; gene.
DR neXtProt; NX_Q03169; -.
DR OpenTargets; ENSG00000185215; -.
DR PharmGKB; PA36592; -.
DR VEuPathDB; HostDB:ENSG00000185215; -.
DR eggNOG; KOG2286; Eukaryota.
DR GeneTree; ENSGT01030000234613; -.
DR HOGENOM; CLU_016260_2_0_1; -.
DR InParanoid; Q03169; -.
DR OMA; MLPFFQS; -.
DR OrthoDB; 391172at2759; -.
DR PhylomeDB; Q03169; -.
DR TreeFam; TF314979; -.
DR PathwayCommons; Q03169; -.
DR SignaLink; Q03169; -.
DR BioGRID-ORCS; 7127; 65 hits in 1082 CRISPR screens.
DR ChiTaRS; TNFAIP2; human.
DR GenomeRNAi; 7127; -.
DR Pharos; Q03169; Tbio.
DR PRO; PR:Q03169; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q03169; protein.
DR Bgee; ENSG00000185215; Expressed in granulocyte and 166 other tissues.
DR ExpressionAtlas; Q03169; baseline and differential.
DR Genevisible; Q03169; HS.
DR GO; GO:0000145; C:exocyst; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; TAS:ProtInc.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0051601; P:exocyst localization; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR Gene3D; 1.10.357.70; -; 1.
DR InterPro; IPR010326; EXOC3/Sec6.
DR InterPro; IPR042532; EXOC3/Sec6_C.
DR PANTHER; PTHR21292; PTHR21292; 1.
DR Pfam; PF06046; Sec6; 1.
PE 1: Evidence at protein level;
KW Angiogenesis; Developmental protein; Differentiation; Reference proteome.
FT CHAIN 1..654
FT /note="Tumor necrosis factor alpha-induced protein 2"
FT /id="PRO_0000118932"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 50..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 110
FT /note="A -> AA"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_038742"
FT VARIANT 282
FT /note="Q -> E (in dbSNP:rs1132339)"
FT /evidence="ECO:0000269|PubMed:1374453, ECO:0000269|Ref.3"
FT /id="VAR_020772"
FT VARIANT 565
FT /note="T -> I (in dbSNP:rs2229727)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_020773"
FT VARIANT 580
FT /note="T -> M (in dbSNP:rs2234146)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_020774"
SQ SEQUENCE 654 AA; 72661 MW; 5BB18E96B193CC3D CRC64;
MSEASSEDLV PPLEAGAAPY REEEEAAKKK KEKKKKSKGL ANVFCVFTKG KKKKGQPSSA
EPEDAAGSRQ GLDGPPPTVE ELKAALERGQ LEAARPLLAL ERELAAAAAA GGVSEEELVR
RQSKVEALYE LLRDQVLGVL RRPLEAPPER LRQALAVVAE QEREDRQAAA AGPGTSGLAA
TRPRRWLQLW RRGVAEAAEE RMGQRPAAGA EVPESVFLHL GRTMKEDLEA VVERLKPLFP
AEFGVVAAYA ESYHQHFAAH LAAVAQFELC ERDTYMLLLW VQNLYPNDII NSPKLVGELQ
GMGLGSLLPP RQIRLLEATF LSSEAANVRE LMDRALELEA RRWAEDVPPQ RLDGHCHSEL
AIDIIQITSQ AQAKAESITL DLGSQIKRVL LVELPAFLRS YQRAFNEFLE RGKQLTNYRA
NVIANINNCL SFRMSMEQNW QVPQDTLSLL LGPLGELKSH GFDTLLQNLH EDLKPLFKRF
THTRWAAPVE TLENIIATVD TRLPEFSELQ GCFREELMEA LHLHLVKEYI IQLSKGRLVL
KTAEQQQQLA GYILANADTI QHFCTQHGSP ATWLQPALPT LAEIIRLQDP SAIKIEVATY
ATCYPDFSKG HLSAILAIKG NLSNSEVKRI RSILDVSMGA QEPSRPLFSL IKVG
