TNAP2_MOUSE
ID TNAP2_MOUSE Reviewed; 691 AA.
AC Q61333; Q3T9B0; Q3TCH9; Q922G1;
DT 25-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 31-MAY-2011, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Tumor necrosis factor alpha-induced protein 2;
DE Short=TNF alpha-induced protein 2;
DE AltName: Full=Primary response gene B94 protein;
GN Name=Tnfaip2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NOD; TISSUE=Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 7-691.
RX PubMed=8106408; DOI=10.1016/s0021-9258(17)41909-0;
RA Wolf F.W., Sarma V., Seldin M., Drake S., Suchard S.J., Shao H.,
RA O'Shea K.S., Dixit V.M.;
RT "B94, a primary response gene inducible by tumor necrosis factor-alpha, is
RT expressed in developing hematopoietic tissues and the sperm acrosome.";
RL J. Biol. Chem. 269:3633-3640(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 489-691.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play a role as a mediator of inflammation and
CC angiogenesis.
CC -!- DEVELOPMENTAL STAGE: In 10-day embryos B94 is expressed prominently in
CC the myocardium and in the aortic arch. By the 15th day of gestation,
CC expression is restricted largely to the liver, the bone forming regions
CC of the jaw, the aortic endothelium, and the nasopharynx: a pattern that
CC is maintained until just prior to birth. Postnatally, expression shifts
CC to the red pulp of the spleen and the thymic medulla.
CC -!- SIMILARITY: Belongs to the SEC6 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA72044.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK154405; BAE32563.1; -; mRNA.
DR EMBL; AK170719; BAE41977.1; -; mRNA.
DR EMBL; AK172653; BAE43114.1; -; mRNA.
DR EMBL; L24118; AAA72044.1; ALT_INIT; mRNA.
DR EMBL; BC008165; AAH08165.1; -; mRNA.
DR CCDS; CCDS26178.2; -.
DR PIR; I49523; I49523.
DR RefSeq; NP_033422.2; NM_009396.2.
DR PDB; 5B86; X-ray; 3.02 A; A/B=94-691.
DR PDBsum; 5B86; -.
DR AlphaFoldDB; Q61333; -.
DR SMR; Q61333; -.
DR STRING; 10090.ENSMUSP00000099806; -.
DR PhosphoSitePlus; Q61333; -.
DR MaxQB; Q61333; -.
DR PaxDb; Q61333; -.
DR PRIDE; Q61333; -.
DR ProteomicsDB; 260717; -.
DR Antibodypedia; 3892; 206 antibodies from 31 providers.
DR DNASU; 21928; -.
DR Ensembl; ENSMUST00000102745; ENSMUSP00000099806; ENSMUSG00000021281.
DR GeneID; 21928; -.
DR KEGG; mmu:21928; -.
DR UCSC; uc007pcz.2; mouse.
DR CTD; 7127; -.
DR MGI; MGI:104960; Tnfaip2.
DR VEuPathDB; HostDB:ENSMUSG00000021281; -.
DR eggNOG; KOG2286; Eukaryota.
DR GeneTree; ENSGT01030000234613; -.
DR InParanoid; Q61333; -.
DR OrthoDB; 391172at2759; -.
DR PhylomeDB; Q61333; -.
DR TreeFam; TF314979; -.
DR BioGRID-ORCS; 21928; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Tnfaip2; mouse.
DR PRO; PR:Q61333; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q61333; protein.
DR Bgee; ENSMUSG00000021281; Expressed in decidua and 202 other tissues.
DR ExpressionAtlas; Q61333; baseline and differential.
DR Genevisible; Q61333; MM.
DR GO; GO:0000145; C:exocyst; IBA:GO_Central.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0051601; P:exocyst localization; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR Gene3D; 1.10.357.70; -; 1.
DR InterPro; IPR010326; EXOC3/Sec6.
DR InterPro; IPR042532; EXOC3/Sec6_C.
DR PANTHER; PTHR21292; PTHR21292; 1.
DR Pfam; PF06046; Sec6; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Angiogenesis; Developmental protein; Differentiation;
KW Reference proteome.
FT CHAIN 1..691
FT /note="Tumor necrosis factor alpha-induced protein 2"
FT /id="PRO_0000118933"
FT REGION 9..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..73
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..111
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 569
FT /note="R -> G (in Ref. 1; BAE41977)"
FT /evidence="ECO:0000305"
FT CONFLICT 687
FT /note="L -> P (in Ref. 1; BAE41977)"
FT /evidence="ECO:0000305"
FT HELIX 114..122
FT /evidence="ECO:0007829|PDB:5B86"
FT HELIX 129..144
FT /evidence="ECO:0007829|PDB:5B86"
FT HELIX 150..176
FT /evidence="ECO:0007829|PDB:5B86"
FT HELIX 184..200
FT /evidence="ECO:0007829|PDB:5B86"
FT TURN 201..204
FT /evidence="ECO:0007829|PDB:5B86"
FT HELIX 220..235
FT /evidence="ECO:0007829|PDB:5B86"
FT HELIX 249..270
FT /evidence="ECO:0007829|PDB:5B86"
FT HELIX 272..275
FT /evidence="ECO:0007829|PDB:5B86"
FT TURN 278..280
FT /evidence="ECO:0007829|PDB:5B86"
FT HELIX 282..301
FT /evidence="ECO:0007829|PDB:5B86"
FT STRAND 302..304
FT /evidence="ECO:0007829|PDB:5B86"
FT HELIX 308..319
FT /evidence="ECO:0007829|PDB:5B86"
FT HELIX 321..325
FT /evidence="ECO:0007829|PDB:5B86"
FT TURN 326..328
FT /evidence="ECO:0007829|PDB:5B86"
FT STRAND 329..331
FT /evidence="ECO:0007829|PDB:5B86"
FT HELIX 333..339
FT /evidence="ECO:0007829|PDB:5B86"
FT HELIX 347..381
FT /evidence="ECO:0007829|PDB:5B86"
FT STRAND 387..393
FT /evidence="ECO:0007829|PDB:5B86"
FT HELIX 395..413
FT /evidence="ECO:0007829|PDB:5B86"
FT HELIX 417..447
FT /evidence="ECO:0007829|PDB:5B86"
FT HELIX 455..476
FT /evidence="ECO:0007829|PDB:5B86"
FT HELIX 481..509
FT /evidence="ECO:0007829|PDB:5B86"
FT HELIX 512..519
FT /evidence="ECO:0007829|PDB:5B86"
FT TURN 520..522
FT /evidence="ECO:0007829|PDB:5B86"
FT HELIX 525..537
FT /evidence="ECO:0007829|PDB:5B86"
FT TURN 538..541
FT /evidence="ECO:0007829|PDB:5B86"
FT HELIX 542..544
FT /evidence="ECO:0007829|PDB:5B86"
FT HELIX 548..570
FT /evidence="ECO:0007829|PDB:5B86"
FT HELIX 580..603
FT /evidence="ECO:0007829|PDB:5B86"
FT HELIX 610..613
FT /evidence="ECO:0007829|PDB:5B86"
FT HELIX 616..623
FT /evidence="ECO:0007829|PDB:5B86"
FT HELIX 627..639
FT /evidence="ECO:0007829|PDB:5B86"
FT HELIX 646..653
FT /evidence="ECO:0007829|PDB:5B86"
FT HELIX 654..656
FT /evidence="ECO:0007829|PDB:5B86"
FT HELIX 662..670
FT /evidence="ECO:0007829|PDB:5B86"
FT STRAND 683..687
FT /evidence="ECO:0007829|PDB:5B86"
SQ SEQUENCE 691 AA; 78102 MW; EFA579705B72F5D2 CRC64;
MLKMVTFFQG FPGQQSVPGT LNFAVSPQKP RSTSEAESET SMSEASSEDL MPSPEAPDGE
EESAKKKEKK SKGLANMFSV FTKGKKKKKD QPRLSDLEVQ PKPRPELDGP LPTVEELKEA
LEHGRLEVAW QVLALERQLE AAAAAGGMSN EELVWRQSKV EALYVLLCDQ VLGVLRRPLE
AAPERLSQAL AVVSQEELED RRASGGPLAA ALEATRPRRW LQRWRGVVAE VAAERLDAQP
ATAPEGRSEA ESRFLHMGRT MKEDLEVVVE RLKPLFPDEF NVVRTYAESY HYHFASHLCA
LAQFELCERD TYLLLLWVQN LYPNDILNSP KLAQELQGVG LGSLLPPKQI RLLEAMFLSN
EVTSVKQLMA RALELESQRW TQDVAPQSLD GHCHSELAID ILQIISQGQT KAENITSDVG
MQIKQLLLVE LAALLRSYQR AFDEFLEKSK LLRNYRVNIM ANINNCLFFW TSVEQKWQIS
HDSLNRLLEP LKDLKAHGFD TLLQSLFLDL KPLFKKFTQT RWANPVETLE EIITTVSSSL
PEFSELQDCF REELMETVHL HLVKEYIIRL CKRRLVLKTA EQQQQLARHI LANADAIQGF
CTENGSTATW LHRALPMIAE IIRLQDSSAI KIEVATYATW YPDFSKGHLN AILAIKGNLP
SSEVRSIRNI LDINTGVQEP PRPLFSLIKV T
