TNC18_HUMAN
ID TNC18_HUMAN Reviewed; 2968 AA.
AC O15417; A8MX41; Q96JH1; Q96K91;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 3.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Trinucleotide repeat-containing gene 18 protein {ECO:0000305};
DE AltName: Full=Long CAG trinucleotide repeat-containing gene 79 protein;
GN Name=TNRC18 {ECO:0000312|HGNC:HGNC:11962}; Synonyms=CAGL79, KIAA1856;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Embryo;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1123-2968 (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=11347906; DOI=10.1093/dnares/8.2.85;
RA Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XX. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 8:85-95(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 2181-2593 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=9225980; DOI=10.1007/s004390050476;
RA Margolis R.L., Abraham M.R., Gatchell S.B., Li S.-H., Kidwai A.S.,
RA Breschel T.S., Stine O.C., Callahan C., McInnis M.G., Ross C.A.;
RT "cDNAs with long CAG trinucleotide repeats from human brain.";
RL Hum. Genet. 100:114-122(1997).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1857, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1857 AND SER-1863, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263; SER-1127; SER-1136;
RP SER-1540; SER-1857; THR-2146 AND SER-2771, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2146, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [10]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-620, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- INTERACTION:
CC O15417; P46934: NEDD4; NbExp=2; IntAct=EBI-2824620, EBI-726944;
CC O15417; P46937: YAP1; NbExp=3; IntAct=EBI-2824620, EBI-1044059;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=O15417-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O15417-2; Sequence=VSP_033126, VSP_033127;
CC Name=4;
CC IsoId=O15417-4; Sequence=VSP_033124, VSP_033128, VSP_033129;
CC -!- MISCELLANEOUS: [Isoform 2]: Dubious isoform produced through aberrant
CC splice sites. {ECO:0000305}.
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DR EMBL; AK027341; BAB55047.1; -; mRNA.
DR EMBL; AC093376; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC093620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB058759; BAB47485.1; -; mRNA.
DR EMBL; U80753; AAB91447.1; -; mRNA.
DR CCDS; CCDS47534.1; -. [O15417-1]
DR RefSeq; NP_001073964.2; NM_001080495.2. [O15417-1]
DR SMR; O15417; -.
DR BioGRID; 124158; 47.
DR IntAct; O15417; 26.
DR MINT; O15417; -.
DR STRING; 9606.ENSP00000395538; -.
DR CarbonylDB; O15417; -.
DR GlyGen; O15417; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; O15417; -.
DR PhosphoSitePlus; O15417; -.
DR BioMuta; TNRC18; -.
DR EPD; O15417; -.
DR jPOST; O15417; -.
DR MassIVE; O15417; -.
DR MaxQB; O15417; -.
DR PaxDb; O15417; -.
DR PeptideAtlas; O15417; -.
DR PRIDE; O15417; -.
DR ProteomicsDB; 48652; -. [O15417-1]
DR ProteomicsDB; 48653; -. [O15417-2]
DR Antibodypedia; 43721; 26 antibodies from 10 providers.
DR Ensembl; ENST00000430969.6; ENSP00000395538.1; ENSG00000182095.15. [O15417-1]
DR GeneID; 84629; -.
DR KEGG; hsa:84629; -.
DR MANE-Select; ENST00000430969.6; ENSP00000395538.1; NM_001080495.3; NP_001073964.2.
DR UCSC; uc003soi.5; human. [O15417-1]
DR CTD; 84629; -.
DR DisGeNET; 84629; -.
DR GeneCards; TNRC18; -.
DR HGNC; HGNC:11962; TNRC18.
DR HPA; ENSG00000182095; Low tissue specificity.
DR neXtProt; NX_O15417; -.
DR OpenTargets; ENSG00000182095; -.
DR PharmGKB; PA36649; -.
DR VEuPathDB; HostDB:ENSG00000182095; -.
DR eggNOG; KOG1886; Eukaryota.
DR GeneTree; ENSGT00940000157099; -.
DR InParanoid; O15417; -.
DR OMA; LHDGKHC; -.
DR OrthoDB; 11077at2759; -.
DR PhylomeDB; O15417; -.
DR TreeFam; TF336007; -.
DR PathwayCommons; O15417; -.
DR SignaLink; O15417; -.
DR BioGRID-ORCS; 84629; 20 hits in 1069 CRISPR screens.
DR ChiTaRS; TNRC18; human.
DR GenomeRNAi; 84629; -.
DR Pharos; O15417; Tdark.
DR PRO; PR:O15417; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; O15417; protein.
DR Bgee; ENSG00000182095; Expressed in sural nerve and 184 other tissues.
DR ExpressionAtlas; O15417; baseline and differential.
DR Genevisible; O15417; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR GO; GO:0031965; C:nuclear membrane; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR Gene3D; 2.30.30.490; -; 1.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR Pfam; PF01426; BAH; 1.
DR SMART; SM00439; BAH; 1.
DR PROSITE; PS51038; BAH; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Isopeptide bond; Phosphoprotein;
KW Reference proteome; Ubl conjugation.
FT CHAIN 1..2968
FT /note="Trinucleotide repeat-containing gene 18 protein"
FT /id="PRO_0000299142"
FT DOMAIN 2817..2962
FT /note="BAH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00370"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 612..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 941..1002
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1019..1055
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1106..1190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1212..1236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1279..1306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1497..1566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1687..1855
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1912..2148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2295..2771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 916..949
FT /evidence="ECO:0000255"
FT COILED 1481..1516
FT /evidence="ECO:0000255"
FT COMPBIAS 139..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..233
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..257
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..319
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..352
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..476
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 941..955
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1024..1046
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1143..1166
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1497..1523
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1750..1764
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1818..1841
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1960..1980
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1989..2004
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2035..2056
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2303..2317
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2327..2350
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2389..2414
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2437..2483
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2554..2580
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2600..2676
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2722..2737
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2746..2771
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 263
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 611
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80WC3"
FT MOD_RES 1127
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 1136
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 1540
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 1857
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19690332,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163"
FT MOD_RES 1863
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT MOD_RES 2146
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163,
FT ECO:0007744|PubMed:24275569"
FT MOD_RES 2771
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT CROSSLNK 620
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 1..1164
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_033124"
FT VAR_SEQ 1403..1478
FT /note="QEMGGAERALVARPSLESLLAAGSHMLREVLDGPVVDPLKNLRLPRELKPNK
FT KYSWMRKKEERMYAMKSSLEDMDA -> PPQGLPPCMGQGSPMPAGLPDCARGPAPTLS
FT GWPRLGEQSRVGLQPGVSVKGTRWRGPGTGPPWSKPSHYRKPQWC (in isoform
FT 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_033128"
FT VAR_SEQ 1479..2968
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_033129"
FT VAR_SEQ 2078..2256
FT /note="HASSLTAAKRSKAKAKGKEVKKENRGKGGAVSKLMESMAAEEDFEPNQDSSF
FT SEDEHLPRGGAVERPLTPAPRSCIIDKDELKDGLRVLIPMDDKLLYAGHVQTVHSPDIY
FT RVVVEGERGNRPHIYCLEQLLQEAIIDVRPASTRFLPQGTRIAAYWSQQYRCLYPGTVV
FT RGLLDLEDD -> PPPPPPPPHPPLPPPPLPPPPLPLRLPPLPPPPLPRPHPPPPPPLP
FT PLLPPPQTRTLPAARTMRQPPPPRLALPRRRRSPPRPPSRPARRGPRPTPQARRRPRPS
FT PRRLLRSPHSLCSPRLRPGPRADPRRERASTSPPPRSWPSGSACRPWRTGPRSPPSCQP
FT GSSGSGSASPPSGVA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11347906"
FT /id="VSP_033126"
FT VAR_SEQ 2257..2968
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11347906"
FT /id="VSP_033127"
FT VARIANT 1193
FT /note="A -> G (in dbSNP:rs12671708)"
FT /id="VAR_042722"
FT CONFLICT 1255
FT /note="V -> A (in Ref. 1; BAB55047)"
FT /evidence="ECO:0000305"
FT CONFLICT 1267
FT /note="A -> G (in Ref. 3; BAB47485)"
FT /evidence="ECO:0000305"
FT CONFLICT 1343
FT /note="N -> S (in Ref. 1; BAB55047)"
FT /evidence="ECO:0000305"
FT CONFLICT 2292
FT /note="S -> P (in Ref. 4; AAB91447)"
FT /evidence="ECO:0000305"
FT CONFLICT 2411
FT /note="P -> S (in Ref. 4; AAB91447)"
FT /evidence="ECO:0000305"
FT CONFLICT 2547
FT /note="A -> V (in Ref. 4; AAB91447)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2968 AA; 314519 MW; C83E5D7E3245740F CRC64;
MDGRDFGPQR SVHGPPPPLL SGLAMDSHRV GAATAGRLPA SGLPGPLPPG KYMAGLNLHP
HPGEAFLGSF VASGMGPSAS SHGSPVPLPS DLSFRSPTPS NLPMVQLWAA HAHEGFSHLP
SGLYPSYLHL NHLEPPSSGS PLLSQLGQPS IFDTQKGQGP GGDGFYLPTA GAPGSLHSHA
PSARTPGGGH SSGAPAKGSS SRDGPAKERA GRGGEPPPLF GKKDPRARGE EASGPRGVVD
LTQEARAEGR QDRGPPRLAE RLSPFLAESK TKNAALQPSV LTMCNGGAGD VGLPALVAEA
GRGGAKEAAR QDEGARLLRR TETLLPGPRP CPSPLPPPPA PPKGPPAPPA ATPAGVYTVF
REQGREHRVV APTFVPSVEA FDERPGPIQI ASQARDARAR EREAGRPGVL QAPPGSPRPL
DRPEGLREKN SVIRSLKRPP PADAPTVRAT RASPDPRAYV PAKELLKPEA DPRPCERAPR
GPAGPAAQQA AKLFGLEPGR PPPTGPEHKW KPFELGNFAA TQMAVLAAQH HHSRAEEEAA
VVAASSSKKA YLDPGAVLPR SAATCGRPVA DMHSAAHGSG EASAMQSLIK YSGSFARDAV
AVRPGGCGKK SPFGGLGTMK PEPAPTSAGA SRAQARLPHS GGPAAGGGRQ LKRDPERPES
AKAFGREGSG AQGEAEVRHP PVGIAVAVAR QKDSGGSGRL GPGLVDQERS LSLSNVKGHG
RADEDCVDDR ARHREERLLG ARLDRDQEKL LRESKELADL ARLHPTSCAP NGLNPNLMVT
GGPALAGSGR WSADPAAHLA THPWLPRSGN ASMWLAGHPY GLGPPSLHQG MAPAFPPGLG
GSLPSAYQFV RDPQSGQLVV IPSDHLPHFA ELMERATVPP LWPALYPPGR SPLHHAQQLQ
LFSQQHFLRQ QEFLYLQQQA AQALELQRSA QLVQERLKAQ EHRAEMEEKG SKRGLEAAGK
AGLATAGPGL LPRKPPGLAA GPAGTYGKAV SPPPSPRASP VAALKAKVIQ KLEDVSKPPA
YAYPATPSSH PTSPPPASPP PTPGITRKEE APENVVEKKD LELEKEAPSP FQALFSDIPP
RYPFQALPPH YGRPYPFLLQ PTAAADADGL APDVPLPADG PERLALSPED KPIRLSPSKI
TEPLREGPEE EPLAEREVKA EVEDMDEGPT ELPPLESPLP LPAAEAMATP SPAGGCGGGL
LEAQALSATG QSCAEPSECP DFVEGPEPRV DSPGRTEPCT AALDLGVQLT PETLVEAKEE
PVEVPVAVPV VEAVPEEGLA QVAPSESQPT LEMSDCDVPA GEGQCPSLEP QEAVPVLGST
CFLEEASSDQ FLPSLEDPLA GMNALAAAAE LPQARPLPSP GAAGAQALEK LEAAESLVLE
QSFLHGITLL SEIAELELER RSQEMGGAER ALVARPSLES LLAAGSHMLR EVLDGPVVDP
LKNLRLPREL KPNKKYSWMR KKEERMYAMK SSLEDMDALE LDFRMRLAEV QRQYKEKQRE
LVKLQRRRDS EDRREEPHRS LARRGPGRPR KRTHAPSALS PPRKRGKSGH SSGKLSSKSL
LTSDDYELGA GIRKRHKGSE EEHDALIGMG KARGRNQTWD EHEASSDFIS QLKIKKKKMA
SDQEQLASKL DKALSLTKQD KLKSPFKFSD SAGGKSKTSG GCGRYLTPYD SLLGKNRKAL
AKGLGLSLKS SREGKHKRAA KTRKMEVGFK ARGQPKSAHS PFASEVSSYS YNTDSEEDEE
FLKDEWPAQG PSSSKLTPSL LCSMVAKNSK AAGGPKLTKR GLAAPRTLKP KPATSRKQPF
CLLLREAEAR SSFSDSSEES FDQDESSEEE DEEEELEEED EASGGGYRLG ARERALSPGL
EESGLGLLAR FAASALPSPT VGPSLSVVQL EAKQKARKKE ERQSLLGTEF EYTDSESEVK
VRKRSPAGLL RPKKGLGEPG PSLAAPTPGA RGPDPSSPDK AKLAVEKGRK ARKLRGPKEP
GFEAGPEASD DDLWTRRRSE RIFLHDASAA APAPVSTAPA TKTSRCAKGG PLSPRKDAGR
AKDRKDPRKK KKGKEAGPGA GLPPPRAPAL PSEARAPHAS SLTAAKRSKA KAKGKEVKKE
NRGKGGAVSK LMESMAAEED FEPNQDSSFS EDEHLPRGGA VERPLTPAPR SCIIDKDELK
DGLRVLIPMD DKLLYAGHVQ TVHSPDIYRV VVEGERGNRP HIYCLEQLLQ EAIIDVRPAS
TRFLPQGTRI AAYWSQQYRC LYPGTVVRGL LDLEDDGDLI TVEFDDGDTG RIPLSHIRLL
PPDYKIQCAE PSPALLVPSA KRRSRKTSKD TGEGKDGGTA GSEEPGAKAR GRGRKPSAKA
KGDRAATLEE GNPTDEVPST PLALEPSSTP GSKKSPPEPV DKRAKAPKAR PAPPQPSPAP
PAFTSCPAPE PFAELPAPAT SLAPAPLITM PATRPKPKKA RAAEESGAKG PRRPGEEAEL
LVKLDHEGVT SPKSKKAKEA LLLREDPGAG GWQEPKSLLS LGSYPPAAGS SEPKAPWPKA
TDGDLAQEPG PGLTFEDSGN PKSPDKAQAE QDGAEESESS SSSSSGSSSS SSSSSSSGSE
TEGEEEGDKN GDGGCGTGGR NCSAASSRAA SPASSSSSSS SSSSSSSSSS SSSSSSSSSS
SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS STTDEDSSCS SDDEAAPAPT AGPSAQAALP
TKATKQAGKA RPSAHSPGKK TPAPQPQAPP PQPTQPLQPK AQAGAKSRPK KREGVHLPTT
KELAKRQRLP SVENRPKIAA FLPARQLWKW FGKPTQRRGM KGKARKLFYK AIVRGKEMIR
IGDCAVFLSA GRPNLPYIGR IQSMWESWGN NMVVRVKWFY HPEETSPGKQ FHQGQHWDQK
SSRSLPAALR VSSQRKDFME RALYQSSHVD ENDVQTVSHK CLVVGLEQYE QMLKTKKYQD
SEGLYYLAGT YEPTTGMIFS TDGVPVLC
