TNF14_MOUSE
ID TNF14_MOUSE Reviewed; 239 AA.
AC Q9QYH9; Q059Y9;
DT 06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Tumor necrosis factor ligand superfamily member 14;
DE AltName: CD_antigen=CD258;
DE Contains:
DE RecName: Full=Tumor necrosis factor ligand superfamily member 14, membrane form;
DE Contains:
DE RecName: Full=Tumor necrosis factor ligand superfamily member 14, soluble form;
GN Name=Tnfsf14; Synonyms=Light;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10700230; DOI=10.1038/73136;
RA Tamada K., Shimozaki K., Chapoval A.I., Zhu G., Sica G., Flies D.,
RA Boone T., Hsu H., Fu Y.-X., Nagata S., Ni J., Chen L.;
RT "Modulation of T-cell-mediated immunity in tumor and graft-versus-host
RT disease models through the LIGHT co-stimulatory pathway.";
RL Nat. Med. 6:283-289(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Fetal liver;
RX PubMed=10894944; DOI=10.1159/000015570;
RA Misawa K., Nosaka T., Kojima T., Hirai M., Kitamura T.;
RT "Molecular cloning and characterization of a mouse homolog of human
RT TNFSF14, a member of the TNF superfamily.";
RL Cytogenet. Cell Genet. 89:89-91(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lymphoma;
RA Force W.R., Todd P.K., Mikayama T.;
RT "Mouse LIGHT; molecular genetics, ligand binding and expression.";
RL Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy
CC receptor TNFRSF6B modulates its effects. Activates NFKB and stimulates
CC the proliferation of T-cells. Acts as a ligand for TNFRSF14/HVEM. Upon
CC binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells,
CC leading to T cell proliferation and IFNG production (By similarity).
CC {ECO:0000250|UniProtKB:O43557}.
CC -!- SUBUNIT: Homotrimer. Interacts with TNFRSF14.
CC {ECO:0000250|UniProtKB:O43557}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type II
CC membrane protein {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member
CC 14, soluble form]: Secreted {ECO:0000250}.
CC -!- PTM: The soluble form derives from the membrane form by proteolytic
CC processing.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family. {ECO:0000305}.
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DR EMBL; AF123385; AAF76453.1; -; mRNA.
DR EMBL; AB029155; BAA88559.1; -; mRNA.
DR EMBL; AF227533; AAF36722.1; -; mRNA.
DR EMBL; BC125477; AAI25478.1; -; mRNA.
DR EMBL; BC125479; AAI25480.1; -; mRNA.
DR CCDS; CCDS28928.1; -.
DR RefSeq; NP_062291.1; NM_019418.3.
DR AlphaFoldDB; Q9QYH9; -.
DR SMR; Q9QYH9; -.
DR BioGRID; 206162; 1.
DR IntAct; Q9QYH9; 2.
DR STRING; 10090.ENSMUSP00000005976; -.
DR GlyGen; Q9QYH9; 2 sites.
DR PhosphoSitePlus; Q9QYH9; -.
DR MaxQB; Q9QYH9; -.
DR PaxDb; Q9QYH9; -.
DR PRIDE; Q9QYH9; -.
DR ProteomicsDB; 259597; -.
DR Antibodypedia; 11882; 680 antibodies from 41 providers.
DR DNASU; 50930; -.
DR Ensembl; ENSMUST00000005976; ENSMUSP00000005976; ENSMUSG00000005824.
DR GeneID; 50930; -.
DR KEGG; mmu:50930; -.
DR UCSC; uc008def.2; mouse.
DR CTD; 8740; -.
DR MGI; MGI:1355317; Tnfsf14.
DR VEuPathDB; HostDB:ENSMUSG00000005824; -.
DR eggNOG; ENOG502RZ4W; Eukaryota.
DR GeneTree; ENSGT01050000244957; -.
DR HOGENOM; CLU_070352_5_1_1; -.
DR InParanoid; Q9QYH9; -.
DR OMA; KSIHCST; -.
DR OrthoDB; 1371007at2759; -.
DR PhylomeDB; Q9QYH9; -.
DR TreeFam; TF332169; -.
DR Reactome; R-MMU-5668541; TNFR2 non-canonical NF-kB pathway.
DR Reactome; R-MMU-5676594; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.
DR BioGRID-ORCS; 50930; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q9QYH9; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q9QYH9; protein.
DR Bgee; ENSMUSG00000005824; Expressed in granulocyte and 31 other tissues.
DR ExpressionAtlas; Q9QYH9; baseline and differential.
DR Genevisible; Q9QYH9; MM.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:MGI.
DR GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; ISS:UniProtKB.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0005102; F:signaling receptor binding; ISS:UniProtKB.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0045663; P:positive regulation of myoblast differentiation; IMP:MGI.
DR GO; GO:1901741; P:positive regulation of myoblast fusion; IMP:MGI.
DR GO; GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; ISS:UniProtKB.
DR GO; GO:0010820; P:positive regulation of T cell chemotaxis; IDA:MGI.
DR GO; GO:0010818; P:T cell chemotaxis; IDA:MGI.
DR GO; GO:0031295; P:T cell costimulation; IDA:MGI.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR006053; TNF.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR Pfam; PF00229; TNF; 1.
DR PRINTS; PR01234; TNECROSISFCT.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; SSF49842; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cytokine; Disulfide bond; Glycoprotein; Membrane;
KW Reference proteome; Secreted; Signal-anchor; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..239
FT /note="Tumor necrosis factor ligand superfamily member 14,
FT membrane form"
FT /id="PRO_0000034534"
FT CHAIN ?82..239
FT /note="Tumor necrosis factor ligand superfamily member 14,
FT soluble form"
FT /id="PRO_0000034535"
FT TOPO_DOM 1..37
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 59..239
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT SITE 81..82
FT /note="Cleavage"
FT /evidence="ECO:0000255"
FT CARBOHYD 100
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 191
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 152..187
FT /evidence="ECO:0000250"
SQ SEQUENCE 239 AA; 26338 MW; 217874AC71AD6BE3 CRC64;
MESVVQPSVF VVDGQTDIPF RRLEQNHRRR RCGTVQVSLA LVLLLGAGLA TQGWFLLRLH
QRLGDIVAHL PDGGKGSWEK LIQDQRSHQA NPAAHLTGAN ASLIGIGGPL LWETRLGLAF
LRGLTYHDGA LVTMEPGYYY VYSKVQLSGV GCPQGLANGL PITHGLYKRT SRYPKELELL
VSRRSPCGRA NSSRVWWDSS FLGGVVHLEA GEEVVVRVPG NRLVRPRDGT RSYFGAFMV
