TNF15_MOUSE
ID TNF15_MOUSE Reviewed; 252 AA.
AC Q5UBV8; Q8K3Y8;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Tumor necrosis factor ligand superfamily member 15;
DE AltName: Full=TNF ligand-related molecule 1;
DE AltName: Full=Vascular endothelial cell growth inhibitor;
GN Name=Tnfsf15; Synonyms=Tl1, Vegi;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC STRAIN=BALB/cJ; TISSUE=Kidney;
RX PubMed=11911831; DOI=10.1016/s1074-7613(02)00283-2;
RA Migone T.-S., Zhang J., Luo X., Zhuang L., Chen C., Hu B., Hong J.S.,
RA Perry J.W., Chen S.-F., Zhou J.X.H., Cho Y.H., Ullrich S., Kanakaraj P.,
RA Carrell J., Boyd E., Olsen H.S., Hu G., Pukac L., Liu D., Ni J., Kim S.,
RA Gentz R., Feng P., Moore P.A., Ruben S.M., Wei P.;
RT "TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell
RT costimulator.";
RL Immunity 16:479-492(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
RC STRAIN=C57BL/6J;
RX PubMed=15702971; DOI=10.1042/bj20041739;
RA Xiao Q., Hsu C.Y., Chen H., Ma X., Xu J., Lee J.-M.;
RT "Characterization of cis-regulatory elements of the vascular endothelial
RT growth inhibitor gene promoter.";
RL Biochem. J. 388:913-920(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C3H/He; TISSUE=Osteoblast;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of
CC NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in
CC vitro). Promotes activation of caspases and apoptosis (By similarity).
CC Promotes splenocyte alloactivation. {ECO:0000250,
CC ECO:0000269|PubMed:11911831}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC membrane protein {ECO:0000305}.
CC -!- INDUCTION: Up-regulated by TNF-alpha. {ECO:0000269|PubMed:15702971}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family. {ECO:0000305}.
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DR EMBL; AF520786; AAM77367.1; -; mRNA.
DR EMBL; AY764130; AAV33431.1; -; mRNA.
DR EMBL; BC096494; AAH96494.1; -; mRNA.
DR CCDS; CCDS18263.2; -.
DR RefSeq; NP_796345.3; NM_177371.3.
DR AlphaFoldDB; Q5UBV8; -.
DR SMR; Q5UBV8; -.
DR BioGRID; 236475; 1.
DR STRING; 10090.ENSMUSP00000050144; -.
DR GlyGen; Q5UBV8; 2 sites.
DR PaxDb; Q5UBV8; -.
DR PRIDE; Q5UBV8; -.
DR DNASU; 326623; -.
DR GeneID; 326623; -.
DR KEGG; mmu:326623; -.
DR CTD; 9966; -.
DR MGI; MGI:2180140; Tnfsf15.
DR eggNOG; ENOG502S4Q1; Eukaryota.
DR InParanoid; Q5UBV8; -.
DR OrthoDB; 1154153at2759; -.
DR PhylomeDB; Q5UBV8; -.
DR Reactome; R-MMU-5669034; TNFs bind their physiological receptors.
DR BioGRID-ORCS; 326623; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Tnfsf15; mouse.
DR PRO; PR:Q5UBV8; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q5UBV8; protein.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005123; F:death receptor binding; ISO:MGI.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISO:MGI.
DR GO; GO:0007250; P:activation of NF-kappaB-inducing kinase activity; ISO:MGI.
DR GO; GO:0006915; P:apoptotic process; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0001819; P:positive regulation of cytokine production; ISO:MGI.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR006053; TNF.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008064; TNFSF15.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR11471:SF24; PTHR11471:SF24; 1.
DR Pfam; PF00229; TNF; 1.
DR PRINTS; PR01234; TNECROSISFCT.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; SSF49842; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 2: Evidence at transcript level;
KW Cytokine; Disulfide bond; Glycoprotein; Membrane; Reference proteome;
KW Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..252
FT /note="Tumor necrosis factor ligand superfamily member 15"
FT /id="PRO_0000333232"
FT TOPO_DOM 1..39
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 61..252
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT SITE 188
FT /note="Important for binding TNFRSF6B"
FT /evidence="ECO:0000250"
FT SITE 191
FT /note="Important for binding TNFRSF6B"
FT /evidence="ECO:0000250"
FT CARBOHYD 137
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 230
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 163..203
FT /evidence="ECO:0000250"
FT CONFLICT 180
FT /note="V -> M (in Ref. 2; AAV33431 and 3; AAH96494)"
FT /evidence="ECO:0000305"
FT CONFLICT 218
FT /note="M -> T (in Ref. 2; AAV33431 and 3; AAH96494)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 252 AA; 27723 MW; BB901C9350119E0F CRC64;
MAEELGLGFG EGVPVEVLPE GCRHRPEARA GLAARSKACL ALTCCLLSFP ILAGLSTLLM
AGQLRVPGKD CMLRAITEER SEPSPQQVYS PPRGKPRAHL TIKKQTPAPH LKNQLSALHW
EHDLGMAFTK NGMKYINKSL VIPESGDYFI YSQITFRGTT SVCGDISRGR RPNKPDSITV
VITKVADSYP EPARLLTGSK SVCEISNNWF QSLYLGAMFS LEEGDRLMVN VSDISLVDYT
KEDKTFFGAF LL
