TNF6B_HUMAN
ID TNF6B_HUMAN Reviewed; 300 AA.
AC O95407;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Tumor necrosis factor receptor superfamily member 6B;
DE AltName: Full=Decoy receptor 3;
DE Short=DcR3;
DE AltName: Full=Decoy receptor for Fas ligand;
DE AltName: Full=M68;
DE Flags: Precursor;
GN Name=TNFRSF6B; Synonyms=DCR3, TR6; ORFNames=UNQ186/PRO212;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Fetal lung;
RX PubMed=9872321; DOI=10.1038/25387;
RA Pitti R.M., Marsters S.A., Lawrence D.A., Roy M., Kischkel F.C., Dowd P.,
RA Huang A., Donahue C.J., Sherwood S.W., Baldwin D.T., Godowski P.J.,
RA Wood W.I., Gurney A.L., Hillan K.J., Cohen R.L., Goddard A.D., Botstein D.,
RA Ashkenazi A.;
RT "Genomic amplification of a decoy receptor for Fas ligand in lung and colon
RT cancer.";
RL Nature 396:699-703(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 30-35.
RC TISSUE=Prostate;
RX PubMed=10318773; DOI=10.1074/jbc.274.20.13733;
RA Yu K.-Y., Kwon B., Ni J., Zhai Y., Ebner R., Kwon B.S.;
RT "A newly identified member of tumor necrosis factor receptor superfamily
RT (TR6) suppresses LIGHT-mediated apoptosis.";
RL J. Biol. Chem. 274:13733-13736(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC TISSUE=Lung;
RX PubMed=10655513; DOI=10.1073/pnas.97.3.1230;
RA Bai C., Connolly B., Metzker M.L., Hilliard C.A., Liu X., Sandig V.,
RA Soderman A., Galloway S.M., Liu Q., Austin C.P., Caskey C.T.;
RT "Overexpression of M68/DcR3 in human gastrointestinal tract tumors
RT independent of gene amplification and its location in a four-gene
RT cluster.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:1230-1235(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 30-195 IN COMPLEX WITH TNFSF15,
RP FUNCTION, AND DISULFIDE BONDS.
RX PubMed=21300286; DOI=10.1016/j.str.2010.12.004;
RA Zhan C., Patskovsky Y., Yan Q., Li Z., Ramagopal U., Cheng H.,
RA Brenowitz M., Hui X., Nathenson S.G., Almo S.C.;
RT "Decoy strategies: the structure of TL1A:DcR3 complex.";
RL Structure 19:162-171(2011).
CC -!- FUNCTION: Decoy receptor that can neutralize the cytotoxic ligands
CC TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.
CC {ECO:0000269|PubMed:21300286}.
CC -!- INTERACTION:
CC O95407; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-524171, EBI-10172052;
CC O95407; O43557: TNFSF14; NbExp=2; IntAct=EBI-524171, EBI-524131;
CC O95407; O43557-1: TNFSF14; NbExp=4; IntAct=EBI-524171, EBI-15910661;
CC O95407; O95150-1: TNFSF15; NbExp=3; IntAct=EBI-524171, EBI-15910629;
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Detected in fetal lung, brain and liver. Detected
CC in adult stomach, spinal cord, lymph node, trachea, spleen, colon and
CC lung. Highly expressed in several primary tumors from colon, stomach,
CC rectum, esophagus and in SW480 colon carcinoma cells.
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/TNFRSF6BID42628ch20q13.html";
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DR EMBL; AF104419; AAD03056.1; -; mRNA.
DR EMBL; AF134240; AAD29688.1; -; mRNA.
DR EMBL; AF217796; AAF35244.1; -; Genomic_DNA.
DR EMBL; AF217793; AAF33685.1; -; mRNA.
DR EMBL; AF217794; AAF33686.1; -; mRNA.
DR EMBL; AY358279; AAQ88646.1; -; mRNA.
DR EMBL; AL121845; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC017065; AAH17065.1; -; mRNA.
DR EMBL; BC034349; AAH34349.1; -; mRNA.
DR CCDS; CCDS13532.1; -.
DR RefSeq; NP_003814.1; NM_003823.3.
DR PDB; 3K51; X-ray; 2.45 A; B=30-195.
DR PDB; 3MHD; X-ray; 2.90 A; D=30-195.
DR PDB; 3MI8; X-ray; 2.95 A; D=30-195.
DR PDB; 4J6G; X-ray; 2.40 A; C/D=30-195.
DR PDB; 4KGG; X-ray; 2.78 A; C/D=30-195.
DR PDB; 4KGQ; X-ray; 2.27 A; C/D=30-195.
DR PDB; 4MSV; X-ray; 2.50 A; B=30-195.
DR PDB; 5L36; X-ray; 3.10 A; B=30-195.
DR PDBsum; 3K51; -.
DR PDBsum; 3MHD; -.
DR PDBsum; 3MI8; -.
DR PDBsum; 4J6G; -.
DR PDBsum; 4KGG; -.
DR PDBsum; 4KGQ; -.
DR PDBsum; 4MSV; -.
DR PDBsum; 5L36; -.
DR AlphaFoldDB; O95407; -.
DR SMR; O95407; -.
DR BioGRID; 114301; 62.
DR IntAct; O95407; 5.
DR STRING; 9606.ENSP00000359013; -.
DR GlyGen; O95407; 2 sites, 1 O-linked glycan (1 site).
DR iPTMnet; O95407; -.
DR PhosphoSitePlus; O95407; -.
DR BioMuta; TNFRSF6B; -.
DR EPD; O95407; -.
DR jPOST; O95407; -.
DR MassIVE; O95407; -.
DR PaxDb; O95407; -.
DR PeptideAtlas; O95407; -.
DR PRIDE; O95407; -.
DR ProteomicsDB; 50860; -.
DR Antibodypedia; 35008; 314 antibodies from 37 providers.
DR DNASU; 8771; -.
DR Ensembl; ENST00000369996.3; ENSP00000359013.1; ENSG00000243509.6.
DR GeneID; 8771; -.
DR KEGG; hsa:8771; -.
DR MANE-Select; ENST00000369996.3; ENSP00000359013.1; NM_003823.4; NP_003814.1.
DR UCSC; uc002yfz.4; human.
DR CTD; 8771; -.
DR DisGeNET; 8771; -.
DR GeneCards; TNFRSF6B; -.
DR HGNC; HGNC:11921; TNFRSF6B.
DR HPA; ENSG00000243509; Tissue enhanced (lung).
DR MIM; 603361; gene.
DR neXtProt; NX_O95407; -.
DR OpenTargets; ENSG00000243509; -.
DR PharmGKB; PA36614; -.
DR VEuPathDB; HostDB:ENSG00000243509; -.
DR eggNOG; ENOG502RZKS; Eukaryota.
DR GeneTree; ENSGT00940000162635; -.
DR HOGENOM; CLU_057708_2_0_1; -.
DR InParanoid; O95407; -.
DR OMA; PGFFAHA; -.
DR OrthoDB; 869160at2759; -.
DR PhylomeDB; O95407; -.
DR TreeFam; TF331157; -.
DR PathwayCommons; O95407; -.
DR Reactome; R-HSA-5669034; TNFs bind their physiological receptors.
DR SignaLink; O95407; -.
DR SIGNOR; O95407; -.
DR BioGRID-ORCS; 8771; 11 hits in 1065 CRISPR screens.
DR EvolutionaryTrace; O95407; -.
DR GeneWiki; TNFRSF6B; -.
DR GenomeRNAi; 8771; -.
DR Pharos; O95407; Tbio.
DR PRO; PR:O95407; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; O95407; protein.
DR Bgee; ENSG00000243509; Expressed in olfactory segment of nasal mucosa and 88 other tissues.
DR Genevisible; O95407; HS.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005615; C:extracellular space; NAS:UniProtKB.
DR GO; GO:0038023; F:signaling receptor activity; TAS:ProtInc.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0043066; P:negative regulation of apoptotic process; TAS:ProtInc.
DR CDD; cd10575; TNFRSF6B; 1.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR034023; TNFRSF6B_N.
DR Pfam; PF00020; TNFR_c6; 3.
DR SMART; SM00208; TNFR; 4.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Apoptosis; Direct protein sequencing; Disulfide bond;
KW Glycoprotein; Receptor; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..29
FT /evidence="ECO:0000269|PubMed:10318773"
FT CHAIN 30..300
FT /note="Tumor necrosis factor receptor superfamily member
FT 6B"
FT /id="PRO_0000034570"
FT REPEAT 31..70
FT /note="TNFR-Cys 1"
FT REPEAT 72..113
FT /note="TNFR-Cys 2"
FT REPEAT 115..150
FT /note="TNFR-Cys 3"
FT REPEAT 152..193
FT /note="TNFR-Cys 4"
FT CARBOHYD 173
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 49..62
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206,
FT ECO:0000269|PubMed:21300286"
FT DISULFID 52..70
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206,
FT ECO:0000269|PubMed:21300286"
FT DISULFID 73..88
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206,
FT ECO:0000269|PubMed:21300286"
FT DISULFID 91..105
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206,
FT ECO:0000269|PubMed:21300286"
FT DISULFID 95..113
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206,
FT ECO:0000269|PubMed:21300286"
FT DISULFID 115..126
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206,
FT ECO:0000269|PubMed:21300286"
FT DISULFID 132..150
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206,
FT ECO:0000269|PubMed:21300286"
FT DISULFID 153..168
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206,
FT ECO:0000269|PubMed:21300286"
FT DISULFID 174..193
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206,
FT ECO:0000269|PubMed:21300286"
FT STRAND 35..39
FT /evidence="ECO:0007829|PDB:4KGQ"
FT TURN 41..43
FT /evidence="ECO:0007829|PDB:4KGQ"
FT STRAND 46..50
FT /evidence="ECO:0007829|PDB:4KGQ"
FT STRAND 56..60
FT /evidence="ECO:0007829|PDB:4KGQ"
FT STRAND 64..66
FT /evidence="ECO:0007829|PDB:4KGQ"
FT STRAND 69..72
FT /evidence="ECO:0007829|PDB:4KGQ"
FT STRAND 81..83
FT /evidence="ECO:0007829|PDB:4KGQ"
FT STRAND 99..103
FT /evidence="ECO:0007829|PDB:4KGQ"
FT STRAND 107..109
FT /evidence="ECO:0007829|PDB:3MI8"
FT STRAND 112..115
FT /evidence="ECO:0007829|PDB:4KGQ"
FT STRAND 119..122
FT /evidence="ECO:0007829|PDB:4KGQ"
FT STRAND 125..128
FT /evidence="ECO:0007829|PDB:4KGQ"
FT STRAND 136..140
FT /evidence="ECO:0007829|PDB:4KGQ"
FT STRAND 144..146
FT /evidence="ECO:0007829|PDB:4KGQ"
FT STRAND 149..152
FT /evidence="ECO:0007829|PDB:4KGQ"
FT STRAND 163..165
FT /evidence="ECO:0007829|PDB:4KGQ"
FT HELIX 174..177
FT /evidence="ECO:0007829|PDB:4KGQ"
FT STRAND 181..183
FT /evidence="ECO:0007829|PDB:4KGQ"
FT STRAND 186..189
FT /evidence="ECO:0007829|PDB:3K51"
FT STRAND 191..193
FT /evidence="ECO:0007829|PDB:3K51"
SQ SEQUENCE 300 AA; 32680 MW; F90AEE33718449AF CRC64;
MRALEGPGLS LLCLVLALPA LLPVPAVRGV AETPTYPWRD AETGERLVCA QCPPGTFVQR
PCRRDSPTTC GPCPPRHYTQ FWNYLERCRY CNVLCGEREE EARACHATHN RACRCRTGFF
AHAGFCLEHA SCPPGAGVIA PGTPSQNTQC QPCPPGTFSA SSSSSEQCQP HRNCTALGLA
LNVPGSSSHD TLCTSCTGFP LSTRVPGAEE CERAVIDFVA FQDISIKRLQ RLLQALEAPE
GWGPTPRAGR AALQLKLRRR LTELLGAQDG ALLVRLLQAL RVARMPGLER SVRERFLPVH
