TNFB_CANLF
ID TNFB_CANLF Reviewed; 204 AA.
AC Q5WR07;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Lymphotoxin-alpha;
DE Short=LT-alpha;
DE AltName: Full=TNF-beta;
DE AltName: Full=Tumor necrosis factor ligand superfamily member 1;
DE Flags: Precursor;
GN Name=LTA; Synonyms=TNFB, TNFSF1;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Wagner J.L., Palti Y., DiDario D.D.;
RT "Gemomic map of a portion of the canine MHC class I histocompatibility
RT complex.";
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Cytokine that in its homotrimeric form binds to
CC TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In
CC its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is
CC produced by lymphocytes and is cytotoxic for a wide range of tumor
CC cells in vitro and in vivo (By similarity). {ECO:0000250,
CC ECO:0000250|UniProtKB:P01374}.
CC -!- SUBUNIT: Homotrimer, and heterotrimer of either two LTB and one LTA
CC subunits or (less prevalent) two LTA and one LTB subunits. Interacts
CC with TNFRSF14. {ECO:0000250|UniProtKB:P01374}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Membrane {ECO:0000250}.
CC Note=The homotrimer is secreted. The heterotrimer is membrane-
CC associated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family. {ECO:0000305}.
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DR EMBL; AY423389; AAR27884.1; -; Genomic_DNA.
DR RefSeq; NP_001300778.1; NM_001313849.1.
DR RefSeq; XP_848886.2; XM_843793.3.
DR AlphaFoldDB; Q5WR07; -.
DR SMR; Q5WR07; -.
DR STRING; 9612.ENSCAFP00000000737; -.
DR PaxDb; Q5WR07; -.
DR Ensembl; ENSCAFT00030009403; ENSCAFP00030008233; ENSCAFG00030005134.
DR Ensembl; ENSCAFT00040017906; ENSCAFP00040015547; ENSCAFG00040009649.
DR Ensembl; ENSCAFT00845018517; ENSCAFP00845014444; ENSCAFG00845010521.
DR GeneID; 607183; -.
DR KEGG; cfa:607183; -.
DR CTD; 4049; -.
DR VEuPathDB; HostDB:ENSCAFG00845010521; -.
DR eggNOG; ENOG502S956; Eukaryota.
DR GeneTree; ENSGT01050000244878; -.
DR HOGENOM; CLU_070352_4_0_1; -.
DR InParanoid; Q5WR07; -.
DR OMA; RSACQNV; -.
DR OrthoDB; 1124938at2759; -.
DR TreeFam; TF332169; -.
DR Reactome; R-CFA-5668541; TNFR2 non-canonical NF-kB pathway.
DR Reactome; R-CFA-5669034; TNFs bind their physiological receptors.
DR Reactome; R-CFA-5676594; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.
DR Proteomes; UP000002254; Chromosome 12.
DR Bgee; ENSCAFG00000000515; Expressed in lymph node and 11 other tissues.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:Ensembl.
DR GO; GO:0006959; P:humoral immune response; IEA:Ensembl.
DR GO; GO:0048535; P:lymph node development; IEA:Ensembl.
DR GO; GO:0002876; P:positive regulation of chronic inflammatory response to antigenic stimulus; IEA:Ensembl.
DR GO; GO:0002925; P:positive regulation of humoral immune response mediated by circulating immunoglobulin; IEA:Ensembl.
DR GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR006053; TNF.
DR InterPro; IPR002960; TNF_beta.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR Pfam; PF00229; TNF; 1.
DR PRINTS; PR01234; TNECROSISFCT.
DR PRINTS; PR01236; TNFBETA.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; SSF49842; 1.
DR PROSITE; PS00251; TNF_1; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Cytokine; Glycoprotein; Membrane; Reference proteome; Secreted; Signal.
FT SIGNAL 1..33
FT /evidence="ECO:0000250"
FT CHAIN 34..204
FT /note="Lymphotoxin-alpha"
FT /id="PRO_0000034462"
FT CARBOHYD 95
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 204 AA; 22033 MW; B1F88591328F80D8 CRC64;
MTPPGRLYLL RVRSAPVLLL LGLLLGLPPG AQGFPGVGIS PSAARTAYQH PQKHFIQGTL
KPAAHLIGDP SIQNSLRWRA NTDRAFLRHG FSLSNNSLLV PTSGLYFVYS QVVFSGEGCF
PKATPTPLYL AHEVQLFSSQ YPFHVPLLSA QKSVCPGPQG PWVRSVYQGA VFLLTQGDQL
STHTDGISHL LLSPSSVFFG AFAL
