TNFB_HUMAN
ID TNFB_HUMAN Reviewed; 205 AA.
AC P01374; Q8N4C3; Q9UKS8;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 2.
DT 03-AUG-2022, entry version 219.
DE RecName: Full=Lymphotoxin-alpha;
DE Short=LT-alpha;
DE AltName: Full=TNF-beta;
DE AltName: Full=Tumor necrosis factor ligand superfamily member 1;
DE Flags: Precursor;
GN Name=LTA; Synonyms=TNFB, TNFSF1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3555974; DOI=10.1101/sqb.1986.051.01.073;
RA Nedospasov S.A., Shakhov A.N., Turetskaya R.L., Mett V.A., Azizov M.M.,
RA Georgiev G.P., Korobko V.G., Dobrynin V.N., Filippov S.A., Bystrov N.S.,
RA Boldyreva E.F., Chuvpilo S.A., Chumakov A.M., Shingarova L.N.,
RA Ovchinnikov Y.A.;
RT "Tandem arrangement of genes coding for tumor necrosis factor (TNF-alpha)
RT and lymphotoxin (TNF-beta) in the human genome.";
RL Cold Spring Harb. Symp. Quant. Biol. 51:611-624(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3001109; DOI=10.1002/jcb.240290302;
RA Nedwin G.E., Jarrett-Nedwin J., Smith D.H., Naylor S.L., Sakaguchi A.Y.,
RA Goeddel D.V., Gray P.W.;
RT "Structure and chromosomal localization of the human lymphotoxin gene.";
RL J. Cell. Biochem. 29:171-181(1985).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3536896; DOI=10.1093/oxfordjournals.jbchem.a121765;
RA Kobayashi Y., Miyamoto D., Asada M., Obinata M., Osawa T.;
RT "Cloning and expression of human lymphotoxin mRNA derived from a human T
RT cell hybridoma.";
RL J. Biochem. 100:727-733(1986).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=6334807; DOI=10.1038/312721a0;
RA Gray P.W., Aggarwal B.B., Benton C.V., Bringman T.S., Henzel W.J.,
RA Jarrett J.A., Leung D.W., Moffat B., Ng P., Svedersky L.P., Palladino M.A.,
RA Nedwin G.E.;
RT "Cloning and expression of cDNA for human lymphotoxin, a lymphokine with
RT tumour necrosis activity.";
RL Nature 312:721-724(1984).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1353024; DOI=10.1016/0014-5793(92)80425-g;
RA Matsuyama N., Okawa N., Tsukii Y., Endo T., Kaji A.;
RT "Nucleotide sequence of a cDNA encoding human tumor necrosis factor beta
RT from B lymphoblastoid cell RPMI 1788.";
RL FEBS Lett. 302:141-144(1992).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8499947; DOI=10.1038/ng0293-137;
RA Iris F.J.M., Bougueleret L., Prieur S., Caterina D., Primas G., Perrot V.,
RA Jurka J., Rodriguez-Tome P., Claverie J.-M., Dausset J., Cohen D.;
RT "Dense Alu clustering and a potential new member of the NF kappa B family
RT within a 90 kilobase HLA class III segment.";
RL Nat. Genet. 3:137-145(1993).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10202016;
RA Neville M.J., Campbell R.D.;
RT "A new member of the Ig superfamily and a V-ATPase G subunit are among the
RT predicted products of novel genes close to the TNF locus in the human
RT MHC.";
RL J. Immunol. 162:4745-4754(1999).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14656967; DOI=10.1101/gr.1736803;
RA Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D.,
RA Hood L.;
RT "Analysis of the gene-dense major histocompatibility complex class III
RT region and its comparison to mouse.";
RL Genome Res. 13:2621-2636(2003).
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Shiina S., Tamiya G., Oka A., Inoko H.;
RT "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region.";
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [10]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ARG-13; PRO-51 AND ASN-60.
RG SeattleSNPs variation discovery resource;
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
RN [11]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ARG-13; PRO-51 AND ASN-60.
RG NIEHS SNPs program;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [12]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-13.
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [13]
RP PARTIAL PROTEIN SEQUENCE, GLYCOSYLATION AT THR-41 AND ASN-96, AND VARIANT
RP ASN-60.
RX PubMed=1451807; DOI=10.1016/0014-5793(92)81467-z;
RA Voigt C.G., Maurer-Fogy I., Adolf G.R.;
RT "Natural human tumor necrosis factor beta (lymphotoxin). Variable O-
RT glycosylation at Thr7, proteolytic processing, and allelic variation.";
RL FEBS Lett. 314:85-88(1992).
RN [14]
RP FUNCTION, SUBUNIT, AND INTERACTION WITH TNFRSF14.
RX PubMed=9462508; DOI=10.1016/s1074-7613(00)80455-0;
RA Mauri D.N., Ebner R., Montgomery R.I., Kochel K.D., Cheung T.C., Yu G.-L.,
RA Ruben S., Murphy M., Eisenberg R.J., Cohen G.H., Spear P.G., Ware C.F.;
RT "LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are
RT ligands for herpesvirus entry mediator.";
RL Immunity 8:21-30(1998).
RN [15]
RP X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
RX PubMed=1733919; DOI=10.1016/s0021-9258(18)45849-8;
RA Eck M.J., Ultsch M., Rinderknecht E., de Vos A.M., Sprang S.R.;
RT "The structure of human lymphotoxin (tumor necrosis factor-beta) at 1.9-A
RT resolution.";
RL J. Biol. Chem. 267:2119-2122(1992).
RN [16]
RP X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 61-205 OF COMPLEX WITH TNFR1.
RX PubMed=8387891; DOI=10.1016/0092-8674(93)90132-a;
RA Banner D.W., D'Arcy A., Janes W., Gentz R., Schoenfeld H.-J., Broger C.,
RA Loetscher H., Lesslauer W.;
RT "Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta
RT complex: implications for TNF receptor activation.";
RL Cell 73:431-445(1993).
RN [17]
RP VARIANT ASN-60.
RX PubMed=1670638; DOI=10.1084/jem.173.1.209;
RA Messer G., Spengler U., Jung M.C., Honold G., Bloemer K., Pape G.R.,
RA Riethmueller G., Weiss E.H.;
RT "Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI
RT polymorphism in the first intron of the human TNF-beta gene correlates with
RT a variant amino acid in position 26 and a reduced level of TNF-beta
RT production.";
RL J. Exp. Med. 173:209-219(1991).
RN [18]
RP VARIANT PRO-125.
RX PubMed=1671667; DOI=10.1007/bf00211695;
RA Abraham L.J., Du D.C., Zahedi K., Dawkins R.L., Whitehead A.S.;
RT "Haplotypic polymorphisms of the TNFB gene.";
RL Immunogenetics 33:50-53(1991).
RN [19]
RP INVOLVEMENT IN PSORIATIC ARTHRITIS SUSCEPTIBILITY.
RX PubMed=12746914; DOI=10.1002/art.10935;
RA Balding J., Kane D., Livingstone W., Mynett-Johnson L., Bresnihan B.,
RA Smith O., FitzGerald O.;
RT "Cytokine gene polymorphisms: association with psoriatic arthritis
RT susceptibility and severity.";
RL Arthritis Rheum. 48:1408-1413(2003).
RN [20]
RP INVOLVEMENT IN LPRS4.
RX PubMed=17353895; DOI=10.1038/ng2000;
RA Alcaies A., Alter A., Antoni G., Orlova M., Nguyen V.T., Singh M.,
RA Vanderborght P.R., Katoch K., Mira M.T., Vu H.T., Ngyuen T.H., Nguyen N.B.,
RA Moraes M., Mehra N., Schurr E., Abel L.;
RT "Stepwise replication identifies a low-producing lymphotoxin-alpha allele
RT as a major risk factor for early-onset leprosy.";
RL Nat. Genet. 39:517-522(2007).
CC -!- FUNCTION: Cytokine that in its homotrimeric form binds to
CC TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (PubMed:9462508). In
CC its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is
CC produced by lymphocytes and is cytotoxic for a wide range of tumor
CC cells in vitro and in vivo. {ECO:0000269|PubMed:9462508}.
CC -!- SUBUNIT: Homotrimer, and heterotrimer of either two LTB and one LTA
CC subunits or (less prevalent) two LTA and one LTB subunits. Interacts
CC with TNFRSF14 (PubMed:9462508). {ECO:0000269|PubMed:9462508}.
CC -!- INTERACTION:
CC P01374; O95870: ABHD16A; NbExp=3; IntAct=EBI-524105, EBI-348517;
CC P01374; Q12797-6: ASPH; NbExp=3; IntAct=EBI-524105, EBI-12092171;
CC P01374; Q9BRI3: SLC30A2; NbExp=5; IntAct=EBI-524105, EBI-8644112;
CC P01374; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-524105, EBI-10982110;
CC -!- SUBCELLULAR LOCATION: Secreted. Membrane. Note=The homotrimer is
CC secreted. The heterotrimer is membrane-associated.
CC -!- POLYMORPHISM: A polymorphism in LTA accounts, in part, for
CC susceptibility to leprosy linked to chromosome 6p21.3 (LPRS4)
CC [MIM:610988].
CC -!- DISEASE: Psoriatic arthritis (PSORAS) [MIM:607507]: An inflammatory,
CC seronegative arthritis associated with psoriasis. It is a heterogeneous
CC disorder ranging from a mild, non-destructive disease to a severe,
CC progressive, erosive arthropathy. Five types of psoriatic arthritis
CC have been defined: asymmetrical oligoarthritis characterized by primary
CC involvement of the small joints of the fingers or toes; asymmetrical
CC arthritis which involves the joints of the extremities; symmetrical
CC polyarthritis characterized by a rheumatoid like pattern that can
CC involve hands, wrists, ankles, and feet; arthritis mutilans, which is a
CC rare but deforming and destructive condition; arthritis of the
CC sacroiliac joints and spine (psoriatic spondylitis).
CC {ECO:0000269|PubMed:12746914}. Note=Disease susceptibility is
CC associated with variants affecting the gene represented in this entry.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Wikipedia; Note=Lymphotoxin entry;
CC URL="https://en.wikipedia.org/wiki/Lymphotoxin";
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/LTAID41209ch6p21.html";
CC -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC URL="http://egp.gs.washington.edu/data/lta/";
CC -!- WEB RESOURCE: Name=SeattleSNPs;
CC URL="http://pga.gs.washington.edu/data/lta/";
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DR EMBL; X01393; CAA25649.1; -; mRNA.
DR EMBL; X02911; CAA26670.1; -; Genomic_DNA.
DR EMBL; D00102; BAA00064.1; -; mRNA.
DR EMBL; M16441; AAA61199.1; -; Genomic_DNA.
DR EMBL; D12614; BAA02139.1; -; mRNA.
DR EMBL; M55913; AAB59455.1; -; Genomic_DNA.
DR EMBL; Z15026; CAA78746.1; -; Genomic_DNA.
DR EMBL; Y14768; CAA75071.1; -; Genomic_DNA.
DR EMBL; AF129756; AAD18092.1; -; Genomic_DNA.
DR EMBL; BA000025; BAB63397.1; -; Genomic_DNA.
DR EMBL; AY070490; AAL49956.1; -; Genomic_DNA.
DR EMBL; AY216498; AAO21135.1; -; Genomic_DNA.
DR EMBL; BC034729; AAH34729.1; -; mRNA.
DR CCDS; CCDS4701.1; -.
DR PIR; A92755; QWHUX.
DR RefSeq; NP_000586.2; NM_000595.3.
DR RefSeq; NP_001153212.1; NM_001159740.2.
DR RefSeq; XP_011512917.1; XM_011514615.2.
DR RefSeq; XP_011512918.1; XM_011514616.2.
DR RefSeq; XP_011512919.1; XM_011514617.2.
DR RefSeq; XP_011512920.1; XM_011514618.1.
DR PDB; 1TNR; X-ray; 2.85 A; A=62-205.
DR PDB; 4MXV; X-ray; 3.20 A; A/B/D=62-205.
DR PDB; 4MXW; X-ray; 3.60 A; A/X=62-205.
DR PDBsum; 1TNR; -.
DR PDBsum; 4MXV; -.
DR PDBsum; 4MXW; -.
DR AlphaFoldDB; P01374; -.
DR SMR; P01374; -.
DR BioGRID; 110227; 26.
DR CORUM; P01374; -.
DR DIP; DIP-2910N; -.
DR IntAct; P01374; 10.
DR MINT; P01374; -.
DR STRING; 9606.ENSP00000403495; -.
DR BindingDB; P01374; -.
DR ChEMBL; CHEMBL2059; -.
DR DrugBank; DB00005; Etanercept.
DR GlyConnect; 354; 6 N-Linked glycans (1 site).
DR GlyGen; P01374; 2 sites, 10 N-linked glycans (1 site).
DR iPTMnet; P01374; -.
DR MetOSite; P01374; -.
DR BioMuta; LTA; -.
DR DMDM; 135940; -.
DR EPD; P01374; -.
DR MassIVE; P01374; -.
DR PaxDb; P01374; -.
DR PeptideAtlas; P01374; -.
DR PRIDE; P01374; -.
DR ABCD; P01374; 18 sequenced antibodies.
DR Antibodypedia; 27173; 822 antibodies from 42 providers.
DR DNASU; 4049; -.
DR Ensembl; ENST00000412851.6; ENSP00000412555.2; ENSG00000230279.8.
DR Ensembl; ENST00000418386.3; ENSP00000413450.2; ENSG00000226979.9.
DR Ensembl; ENST00000426845.1; ENSP00000402413.1; ENSG00000230279.8.
DR Ensembl; ENST00000436519.5; ENSP00000395976.1; ENSG00000231408.8.
DR Ensembl; ENST00000454550.2; ENSP00000416509.2; ENSG00000231408.8.
DR Ensembl; ENST00000454783.5; ENSP00000403495.1; ENSG00000226979.9.
DR GeneID; 4049; -.
DR KEGG; hsa:4049; -.
DR MANE-Select; ENST00000418386.3; ENSP00000413450.2; NM_000595.4; NP_000586.2.
DR CTD; 4049; -.
DR DisGeNET; 4049; -.
DR GeneCards; LTA; -.
DR HGNC; HGNC:6709; LTA.
DR HPA; ENSG00000226979; Group enriched (intestine, lymphoid tissue, testis).
DR MalaCards; LTA; -.
DR MIM; 153440; gene.
DR MIM; 607507; phenotype.
DR MIM; 610988; phenotype.
DR neXtProt; NX_P01374; -.
DR OpenTargets; ENSG00000226979; -.
DR PharmGKB; PA30474; -.
DR VEuPathDB; HostDB:ENSG00000226979; -.
DR eggNOG; ENOG502S4K8; Eukaryota.
DR GeneTree; ENSGT01050000244878; -.
DR HOGENOM; CLU_070352_4_0_1; -.
DR InParanoid; P01374; -.
DR OMA; RSACQNV; -.
DR OrthoDB; 1124938at2759; -.
DR PhylomeDB; P01374; -.
DR TreeFam; TF332169; -.
DR PathwayCommons; P01374; -.
DR Reactome; R-HSA-5668541; TNFR2 non-canonical NF-kB pathway.
DR Reactome; R-HSA-5669034; TNFs bind their physiological receptors.
DR Reactome; R-HSA-5676594; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.
DR SignaLink; P01374; -.
DR SIGNOR; P01374; -.
DR BioGRID-ORCS; 4049; 8 hits in 1067 CRISPR screens.
DR EvolutionaryTrace; P01374; -.
DR GeneWiki; Lymphotoxin_alpha; -.
DR GenomeRNAi; 4049; -.
DR Pharos; P01374; Tbio.
DR PRO; PR:P01374; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; P01374; protein.
DR Bgee; ENSG00000226979; Expressed in granulocyte and 89 other tissues.
DR ExpressionAtlas; P01374; baseline and differential.
DR Genevisible; P01374; HS.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; TAS:ProtInc.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; TAS:ProtInc.
DR GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:Ensembl.
DR GO; GO:0006959; P:humoral immune response; IEA:Ensembl.
DR GO; GO:0048535; P:lymph node development; IEA:Ensembl.
DR GO; GO:0048147; P:negative regulation of fibroblast proliferation; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0002876; P:positive regulation of chronic inflammatory response to antigenic stimulus; IEA:Ensembl.
DR GO; GO:0060252; P:positive regulation of glial cell proliferation; IEA:Ensembl.
DR GO; GO:0002925; P:positive regulation of humoral immune response mediated by circulating immunoglobulin; IEA:Ensembl.
DR GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:0007584; P:response to nutrient; IEA:Ensembl.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; TAS:ProtInc.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR006053; TNF.
DR InterPro; IPR002960; TNF_beta.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR Pfam; PF00229; TNF; 1.
DR PRINTS; PR01234; TNECROSISFCT.
DR PRINTS; PR01236; TNFBETA.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; SSF49842; 1.
DR PROSITE; PS00251; TNF_1; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytokine; Direct protein sequencing; Glycoprotein; Membrane;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..34
FT CHAIN 35..205
FT /note="Lymphotoxin-alpha"
FT /id="PRO_0000034463"
FT CARBOHYD 41
FT /note="O-linked (GalNAc...) threonine; partial"
FT /evidence="ECO:0000269|PubMed:1451807"
FT CARBOHYD 96
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:1451807"
FT /id="CAR_000048"
FT VARIANT 13
FT /note="C -> R (in dbSNP:rs2229094)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.10,
FT ECO:0000269|Ref.11"
FT /id="VAR_013023"
FT VARIANT 51
FT /note="H -> P (in dbSNP:rs2229092)"
FT /evidence="ECO:0000269|Ref.10, ECO:0000269|Ref.11"
FT /id="VAR_013024"
FT VARIANT 60
FT /note="T -> N (in allele TNFB*2; dbSNP:rs1041981)"
FT /evidence="ECO:0000269|PubMed:1451807,
FT ECO:0000269|PubMed:1670638, ECO:0000269|Ref.10,
FT ECO:0000269|Ref.11"
FT /id="VAR_007511"
FT VARIANT 125
FT /note="T -> P (in allele 8.1)"
FT /evidence="ECO:0000269|PubMed:1671667"
FT /id="VAR_007512"
FT STRAND 64..69
FT /evidence="ECO:0007829|PDB:1TNR"
FT TURN 71..73
FT /evidence="ECO:0007829|PDB:4MXV"
FT STRAND 74..76
FT /evidence="ECO:0007829|PDB:1TNR"
FT STRAND 87..89
FT /evidence="ECO:0007829|PDB:1TNR"
FT STRAND 93..95
FT /evidence="ECO:0007829|PDB:1TNR"
FT STRAND 98..100
FT /evidence="ECO:0007829|PDB:1TNR"
FT STRAND 103..117
FT /evidence="ECO:0007829|PDB:1TNR"
FT HELIX 122..125
FT /evidence="ECO:0007829|PDB:1TNR"
FT STRAND 129..138
FT /evidence="ECO:0007829|PDB:1TNR"
FT STRAND 142..144
FT /evidence="ECO:0007829|PDB:1TNR"
FT STRAND 146..155
FT /evidence="ECO:0007829|PDB:1TNR"
FT STRAND 163..175
FT /evidence="ECO:0007829|PDB:1TNR"
FT STRAND 180..186
FT /evidence="ECO:0007829|PDB:1TNR"
FT HELIX 188..190
FT /evidence="ECO:0007829|PDB:1TNR"
FT TURN 195..197
FT /evidence="ECO:0007829|PDB:1TNR"
FT STRAND 198..204
FT /evidence="ECO:0007829|PDB:1TNR"
SQ SEQUENCE 205 AA; 22297 MW; 1BBD5E7D496A3A82 CRC64;
MTPPERLFLP RVCGTTLHLL LLGLLLVLLP GAQGLPGVGL TPSAAQTARQ HPKMHLAHST
LKPAAHLIGD PSKQNSLLWR ANTDRAFLQD GFSLSNNSLL VPTSGIYFVY SQVVFSGKAY
SPKATSSPLY LAHEVQLFSS QYPFHVPLLS SQKMVYPGLQ EPWLHSMYHG AAFQLTQGDQ
LSTHTDGIPH LVLSPSTVFF GAFAL
