ID   TNFB_MACMU              Reviewed;         205 AA.
AC   Q5TM20;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Lymphotoxin-alpha;
DE            Short=LT-alpha;
DE   AltName: Full=TNF-beta;
DE   AltName: Full=Tumor necrosis factor ligand superfamily member 1;
DE   Flags: Precursor;
GN   Name=LTA; Synonyms=TNFB, TNFSF1;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15269276; DOI=10.1093/molbev/msh216;
RA   Kulski J.K., Anzai T., Shiina T., Inoko H.;
RT   "Rhesus macaque class I duplicon structures, organization, and evolution
RT   within the alpha block of the major histocompatibility complex.";
RL   Mol. Biol. Evol. 21:2079-2091(2004).
CC   -!- FUNCTION: Cytokine that in its homotrimeric form binds to
CC       TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In
CC       its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is
CC       produced by lymphocytes and is cytotoxic for a wide range of tumor
CC       cells in vitro and in vivo. {ECO:0000250|UniProtKB:P01374}.
CC   -!- SUBUNIT: Homotrimer, and heterotrimer of either two LTB and one LTA
CC       subunits or (less prevalent) two LTA and one LTB subunits. Interacts
CC       with TNFRSF14. {ECO:0000250|UniProtKB:P01374}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Membrane {ECO:0000250}.
CC       Note=The homotrimer is secreted. The heterotrimer is membrane-
CC       associated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the tumor necrosis factor family. {ECO:0000305}.
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DR   EMBL; AB128049; BAD69725.1; -; Genomic_DNA.
DR   RefSeq; NP_001040613.1; NM_001047148.1.
DR   RefSeq; XP_014991411.1; XM_015135925.1.
DR   RefSeq; XP_014991412.1; XM_015135926.1.
DR   AlphaFoldDB; Q5TM20; -.
DR   SMR; Q5TM20; -.
DR   STRING; 9544.ENSMMUP00000011590; -.
DR   Ensembl; ENSMMUT00000012357; ENSMMUP00000011590; ENSMMUG00000008843.
DR   GeneID; 715425; -.
DR   KEGG; mcc:715425; -.
DR   CTD; 4049; -.
DR   VEuPathDB; HostDB:ENSMMUG00000008843; -.
DR   VGNC; VGNC:74452; LTA.
DR   eggNOG; ENOG502S4K8; Eukaryota.
DR   GeneTree; ENSGT01050000244878; -.
DR   HOGENOM; CLU_070352_4_0_1; -.
DR   InParanoid; Q5TM20; -.
DR   OMA; RSACQNV; -.
DR   OrthoDB; 1124938at2759; -.
DR   TreeFam; TF332169; -.
DR   Proteomes; UP000006718; Chromosome 4.
DR   Bgee; ENSMMUG00000008843; Expressed in spleen and 2 other tissues.
DR   ExpressionAtlas; Q5TM20; baseline.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:Ensembl.
DR   GO; GO:0006959; P:humoral immune response; IEA:Ensembl.
DR   GO; GO:0048535; P:lymph node development; IEA:Ensembl.
DR   GO; GO:0002876; P:positive regulation of chronic inflammatory response to antigenic stimulus; IEA:Ensembl.
DR   GO; GO:0002925; P:positive regulation of humoral immune response mediated by circulating immunoglobulin; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   CDD; cd00184; TNF; 1.
DR   Gene3D; 2.60.120.40; -; 1.
DR   InterPro; IPR006053; TNF.
DR   InterPro; IPR002960; TNF_beta.
DR   InterPro; IPR021184; TNF_CS.
DR   InterPro; IPR006052; TNF_dom.
DR   InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR   Pfam; PF00229; TNF; 1.
DR   PRINTS; PR01234; TNECROSISFCT.
DR   PRINTS; PR01236; TNFBETA.
DR   SMART; SM00207; TNF; 1.
DR   SUPFAM; SSF49842; SSF49842; 1.
DR   PROSITE; PS00251; TNF_1; 1.
DR   PROSITE; PS50049; TNF_2; 1.
PE   3: Inferred from homology;
KW   Cytokine; Glycoprotein; Membrane; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..34
FT                   /evidence="ECO:0000250"
FT   CHAIN           35..205
FT                   /note="Lymphotoxin-alpha"
FT                   /id="PRO_0000034465"
FT   CARBOHYD        41
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        96
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   205 AA;  22360 MW;  5EE2A7FCE556548A CRC64;
     MTPPERLFLS RVRGTPLHLL LLGLLLVLLP GAQGLPGVGL TPSAAQTARQ HPKMHLAHST
     LKPAAHLIGD PSKQNSLLWR ANTDRAFLQD GFSLSNNSLL VPTSGIYFVY SQVVFSGKAY
     SPKATPTPLY LAHEVQLFSS QYPFHVPLLS SQKMVYPGLQ EPWLHSMYHG AAFQLTQGDQ
     LSTHTDGIPH LVLSPSTVFF GAFAL