TNFB_PANTR
ID TNFB_PANTR Reviewed; 205 AA.
AC P61125; Q1XHZ7;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Lymphotoxin-alpha;
DE Short=LT-alpha;
DE AltName: Full=TNF-beta;
DE AltName: Full=Tumor necrosis factor ligand superfamily member 1;
DE Flags: Precursor;
GN Name=LTA; Synonyms=TNFB, TNFSF1;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12493009; DOI=10.1034/j.1600-065x.2002.19008.x;
RA Kulski J.K., Shiina T., Anzai T., Kohara S., Inoko H.;
RT "Comparative genomic analysis of the MHC: the evolution of class I
RT duplication blocks, diversity and complexity from shark to man.";
RL Immunol. Rev. 190:95-122(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12799463; DOI=10.1073/pnas.1230533100;
RA Anzai T., Shiina T., Kimura N., Yanagiya K., Kohara S., Shigenari A.,
RA Yamagata T., Kulski J.K., Naruse T.K., Fujimori Y., Fukuzumi Y.,
RA Yamazaki M., Tashiro H., Iwamoto C., Umehara Y., Imanishi T., Meyer A.,
RA Ikeo K., Gojobori T., Bahram S., Inoko H.;
RT "Comparative sequencing of human and chimpanzee MHC class I regions unveils
RT insertions/deletions as the major path to genomic divergence.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7708-7713(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16702430; DOI=10.1534/genetics.106.057034;
RA Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M.,
RA Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K.,
RA Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A.,
RA Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T.,
RA Inoko H., Bahram S.;
RT "Rapid evolution of major histocompatibility complex class I genes in
RT primates generates new disease alleles in humans via hitchhiking
RT diversity.";
RL Genetics 173:1555-1570(2006).
CC -!- FUNCTION: Cytokine that in its homotrimeric form binds to
CC TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In
CC its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is
CC produced by lymphocytes and is cytotoxic for a wide range of tumor
CC cells in vitro and in vivo (By similarity). {ECO:0000250,
CC ECO:0000250|UniProtKB:P01374}.
CC -!- SUBUNIT: Homotrimer, and heterotrimer of either two LTB and one LTA
CC subunits or (less prevalent) two LTA and one LTB subunits. Interacts
CC with TNFRSF14. {ECO:0000250|UniProtKB:P01374}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Membrane {ECO:0000250}.
CC Note=The homotrimer is secreted. The heterotrimer is membrane-
CC associated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family. {ECO:0000305}.
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DR EMBL; AB054536; BAB83883.1; -; Genomic_DNA.
DR EMBL; BA000041; BAC78158.1; -; Genomic_DNA.
DR EMBL; AB210165; BAE92771.1; -; Genomic_DNA.
DR EMBL; AB210166; BAE92773.1; -; Genomic_DNA.
DR RefSeq; NP_001038975.1; NM_001045510.1.
DR RefSeq; XP_009449138.1; XM_009450863.2.
DR RefSeq; XP_016810225.1; XM_016954736.1.
DR AlphaFoldDB; P61125; -.
DR SMR; P61125; -.
DR STRING; 9598.ENSPTRP00000030651; -.
DR PaxDb; P61125; -.
DR Ensembl; ENSPTRT00000033173; ENSPTRP00000030651; ENSPTRG00000017964.
DR GeneID; 494185; -.
DR KEGG; ptr:494185; -.
DR CTD; 4049; -.
DR VGNC; VGNC:11106; LTA.
DR eggNOG; ENOG502S4K8; Eukaryota.
DR GeneTree; ENSGT01050000244878; -.
DR HOGENOM; CLU_070352_4_0_1; -.
DR InParanoid; P61125; -.
DR OMA; RSACQNV; -.
DR OrthoDB; 1124938at2759; -.
DR TreeFam; TF332169; -.
DR Proteomes; UP000002277; Chromosome 6.
DR Bgee; ENSPTRG00000017964; Expressed in testis and 1 other tissue.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:Ensembl.
DR GO; GO:0006959; P:humoral immune response; IEA:Ensembl.
DR GO; GO:0048535; P:lymph node development; IEA:Ensembl.
DR GO; GO:0002876; P:positive regulation of chronic inflammatory response to antigenic stimulus; IEA:Ensembl.
DR GO; GO:0002925; P:positive regulation of humoral immune response mediated by circulating immunoglobulin; IEA:Ensembl.
DR GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR006053; TNF.
DR InterPro; IPR002960; TNF_beta.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR Pfam; PF00229; TNF; 1.
DR PRINTS; PR01234; TNECROSISFCT.
DR PRINTS; PR01236; TNFBETA.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; SSF49842; 1.
DR PROSITE; PS00251; TNF_1; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Cytokine; Glycoprotein; Membrane; Reference proteome; Secreted; Signal.
FT SIGNAL 1..34
FT /evidence="ECO:0000250"
FT CHAIN 35..205
FT /note="Lymphotoxin-alpha"
FT /id="PRO_0000034468"
FT CARBOHYD 41
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000250"
FT CARBOHYD 96
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 205 AA; 22350 MW; E102E1CD53D58A98 CRC64;
MTPPERLFLP RVRGTTLHLL LLGLLLVLLP GAQGLPGVGL TPSAAQTARQ HPKMHLAHST
LKPAAHLIGD PSKQNSLLWR ANTDRAFLQD GFSLSNNSLL VPTSGIYFVY SQVVFSGKAY
SPKATSSPLY LAHEVQLFSS QYPFHVPLLS SQKMVYPGLQ EPWLHSMYHG AAFQLTQGDQ
LSTHTDGIPH LVLSPSTVFF GAFAL
