TNFB_PIG
ID TNFB_PIG Reviewed; 204 AA.
AC P26445; A5D9N9;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1992, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Lymphotoxin-alpha;
DE Short=LT-alpha;
DE AltName: Full=TNF-beta;
DE AltName: Full=Tumor necrosis factor ligand superfamily member 1;
DE Flags: Precursor;
GN Name=LTA; Synonyms=TNFB, TNFSF1;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Liver;
RX PubMed=1874444; DOI=10.1016/0378-1119(91)90075-m;
RA Kuhnert P., Wuethrich C., Peterhans E., Pauli U.;
RT "The porcine tumor necrosis factor-encoding genes: sequence and comparative
RT analysis.";
RL Gene 102:171-178(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Large white; TISSUE=Fibroblast;
RX PubMed=11169259; DOI=10.1034/j.1399-0039.2001.057001055.x;
RA Chardon P., Rogel-Gaillard C., Cattolico L., Duprat S., Vaiman M.,
RA Renard C.;
RT "Sequence of the swine major histocompatibility complex region containing
RT all non-classical class I genes.";
RL Tissue Antigens 57:55-65(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Porcine genome sequencing project;
RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Cytokine that in its homotrimeric form binds to
CC TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In
CC its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is
CC produced by lymphocytes and is cytotoxic for a wide range of tumor
CC cells in vitro and in vivo. {ECO:0000250|UniProtKB:P01374}.
CC -!- SUBUNIT: Homotrimer, and heterotrimer of either two LTB and one LTA
CC subunits or (less prevalent) two LTA and one LTB subunits. Interacts
CC with TNFRSF14. {ECO:0000250|UniProtKB:P01374}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Membrane {ECO:0000250}.
CC Note=The homotrimer is secreted. The heterotrimer is membrane-
CC associated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family. {ECO:0000305}.
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DR EMBL; X54859; CAA38638.1; -; Genomic_DNA.
DR EMBL; AJ251914; CAB63853.1; -; Genomic_DNA.
DR EMBL; BX548169; CAN59690.1; -; Genomic_DNA.
DR PIR; S17289; S17289.
DR RefSeq; NP_999618.1; NM_214453.1.
DR AlphaFoldDB; P26445; -.
DR SMR; P26445; -.
DR STRING; 9823.ENSSSCP00000001490; -.
DR PaxDb; P26445; -.
DR Ensembl; ENSSSCT00000034506; ENSSSCP00000028564; ENSSSCG00000001403.
DR Ensembl; ENSSSCT00005051223; ENSSSCP00005031671; ENSSSCG00005032113.
DR Ensembl; ENSSSCT00005051271; ENSSSCP00005031708; ENSSSCG00005032113.
DR Ensembl; ENSSSCT00015076476; ENSSSCP00015030724; ENSSSCG00015057385.
DR Ensembl; ENSSSCT00015076721; ENSSSCP00015030833; ENSSSCG00015057385.
DR Ensembl; ENSSSCT00025108214; ENSSSCP00025048969; ENSSSCG00025077752.
DR Ensembl; ENSSSCT00025108215; ENSSSCP00025048970; ENSSSCG00025077752.
DR Ensembl; ENSSSCT00030091914; ENSSSCP00030042302; ENSSSCG00030065787.
DR Ensembl; ENSSSCT00030091932; ENSSSCP00030042313; ENSSSCG00030065787.
DR Ensembl; ENSSSCT00035025316; ENSSSCP00035009571; ENSSSCG00035019536.
DR Ensembl; ENSSSCT00040097162; ENSSSCP00040043299; ENSSSCG00040070752.
DR Ensembl; ENSSSCT00040097211; ENSSSCP00040043321; ENSSSCG00040070752.
DR Ensembl; ENSSSCT00045065801; ENSSSCP00045046587; ENSSSCG00045038040.
DR Ensembl; ENSSSCT00045065841; ENSSSCP00045046623; ENSSSCG00045038040.
DR Ensembl; ENSSSCT00050007998; ENSSSCP00050003405; ENSSSCG00050005882.
DR Ensembl; ENSSSCT00050008003; ENSSSCP00050003407; ENSSSCG00050005882.
DR Ensembl; ENSSSCT00055057123; ENSSSCP00055045693; ENSSSCG00055028789.
DR Ensembl; ENSSSCT00055057155; ENSSSCP00055045722; ENSSSCG00055028789.
DR Ensembl; ENSSSCT00060058463; ENSSSCP00060025023; ENSSSCG00060043124.
DR Ensembl; ENSSSCT00060058470; ENSSSCP00060025028; ENSSSCG00060043124.
DR Ensembl; ENSSSCT00065034394; ENSSSCP00065014269; ENSSSCG00065025686.
DR Ensembl; ENSSSCT00070048168; ENSSSCP00070040662; ENSSSCG00070024123.
DR Ensembl; ENSSSCT00070048171; ENSSSCP00070040664; ENSSSCG00070024123.
DR GeneID; 407742; -.
DR KEGG; ssc:407742; -.
DR CTD; 4049; -.
DR VGNC; VGNC:89881; LTA.
DR eggNOG; ENOG502S4K8; Eukaryota.
DR GeneTree; ENSGT01050000244878; -.
DR HOGENOM; CLU_070352_4_0_1; -.
DR InParanoid; P26445; -.
DR OMA; MEGECKV; -.
DR OrthoDB; 1124938at2759; -.
DR TreeFam; TF332169; -.
DR Reactome; R-SSC-5669034; TNFs bind their physiological receptors.
DR Proteomes; UP000008227; Chromosome 7.
DR Proteomes; UP000314985; Chromosome 7.
DR Bgee; ENSSSCG00000001403; Expressed in blood and 11 other tissues.
DR ExpressionAtlas; P26445; baseline and differential.
DR Genevisible; P26445; SS.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:Ensembl.
DR GO; GO:0006959; P:humoral immune response; ISS:AgBase.
DR GO; GO:0048535; P:lymph node development; ISS:AgBase.
DR GO; GO:0002876; P:positive regulation of chronic inflammatory response to antigenic stimulus; IEA:Ensembl.
DR GO; GO:0002925; P:positive regulation of humoral immune response mediated by circulating immunoglobulin; IEA:Ensembl.
DR GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR006053; TNF.
DR InterPro; IPR002960; TNF_beta.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR Pfam; PF00229; TNF; 1.
DR PRINTS; PR01234; TNECROSISFCT.
DR PRINTS; PR01236; TNFBETA.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; SSF49842; 1.
DR PROSITE; PS00251; TNF_1; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Cytokine; Glycoprotein; Membrane; Reference proteome; Secreted; Signal.
FT SIGNAL 1..33
FT CHAIN 34..204
FT /note="Lymphotoxin-alpha"
FT /id="PRO_0000034469"
FT CARBOHYD 95
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 204 AA; 21960 MW; 81263187435E56AC CRC64;
MTPPGRLYLR RVCSTPILLL LGLLLALPPE AQGLPGVGLP PSAAQPAHQH PPKHLARGTL
KPAAHLVGDP STPDSLRWRA NTDRAFLRHG FLLSNNSLLV PTSGLYFVYS QVVFSGEGCF
PKATPTPLYL AHEVQLFSSQ YPFHVPLLSA QKSVCPGPQG PWVRSVYQGA VFLLTQGDQL
STHTDGTPHL LLSPSSVFFG AFAL
