TNFB_RABIT
ID TNFB_RABIT Reviewed; 197 AA.
AC P10154;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1991, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Lymphotoxin-alpha;
DE Short=LT-alpha;
DE AltName: Full=TNF-beta;
DE AltName: Full=Tumor necrosis factor ligand superfamily member 1;
DE Flags: Precursor;
GN Name=LTA; Synonyms=TNFB, TNFSF1;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2249779; DOI=10.1016/0378-1119(90)90364-w;
RA Shakhov A.N., Kuprash D.V., Azizov M.M., Jongeneel C.V., Nedospasov S.A.;
RT "Structural analysis of the rabbit TNF locus, containing the genes encoding
RT TNF-beta (lymphotoxin) and TNF-alpha (tumor necrosis factor).";
RL Gene 95:215-221(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2633043;
RA Shakhov A.N., Kuprash D.V., Turetskaya R.L., Azizov M.M., Andreyeva A.V.,
RA Nedospasov S.A.;
RT "Cloning and structural analysis of genes coding for tumor necrosis factor
RT and lymphotoxin in rabbits.";
RL Mol. Biol. (Mosk.) 23:1743-1750(1989).
CC -!- FUNCTION: Cytokine that in its homotrimeric form binds to
CC TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In
CC its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is
CC produced by lymphocytes and is cytotoxic for a wide range of tumor
CC cells in vitro and in vivo. {ECO:0000250|UniProtKB:P01374}.
CC -!- SUBUNIT: Homotrimer, and heterotrimer of either two LTB and one LTA
CC subunits or (less prevalent) two LTA and one LTB subunits. Interacts
CC with TNFRSF14. {ECO:0000250|UniProtKB:P01374}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Membrane {ECO:0000250}.
CC Note=The homotrimer is secreted. The heterotrimer is membrane-
CC associated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family. {ECO:0000305}.
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DR EMBL; X55745; CAA39275.1; ALT_SEQ; Genomic_DNA.
DR EMBL; M60340; AAA31483.1; -; Genomic_DNA.
DR EMBL; M60341; AAA31485.1; -; Genomic_DNA.
DR PIR; JH0309; JH0309.
DR RefSeq; NP_001164590.1; NM_001171119.1.
DR AlphaFoldDB; P10154; -.
DR SMR; P10154; -.
DR STRING; 9986.ENSOCUP00000005782; -.
DR PRIDE; P10154; -.
DR Ensembl; ENSOCUT00000006691; ENSOCUP00000005782; ENSOCUG00000006694.
DR GeneID; 100328931; -.
DR KEGG; ocu:100328931; -.
DR CTD; 4049; -.
DR eggNOG; ENOG502S956; Eukaryota.
DR GeneTree; ENSGT01050000244878; -.
DR HOGENOM; CLU_070352_4_0_1; -.
DR InParanoid; P10154; -.
DR OMA; MEGECKV; -.
DR OrthoDB; 1124938at2759; -.
DR TreeFam; TF332169; -.
DR Proteomes; UP000001811; Chromosome 12.
DR Bgee; ENSOCUG00000006694; Expressed in blood and 3 other tissues.
DR ExpressionAtlas; P10154; baseline.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:Ensembl.
DR GO; GO:0006959; P:humoral immune response; IEA:Ensembl.
DR GO; GO:0048535; P:lymph node development; IEA:Ensembl.
DR GO; GO:0002876; P:positive regulation of chronic inflammatory response to antigenic stimulus; IEA:Ensembl.
DR GO; GO:0002925; P:positive regulation of humoral immune response mediated by circulating immunoglobulin; IEA:Ensembl.
DR GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR006053; TNF.
DR InterPro; IPR002960; TNF_beta.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR Pfam; PF00229; TNF; 1.
DR PRINTS; PR01234; TNECROSISFCT.
DR PRINTS; PR01236; TNFBETA.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; SSF49842; 1.
DR PROSITE; PS00251; TNF_1; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Cytokine; Glycoprotein; Membrane; Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT CHAIN 27..197
FT /note="Lymphotoxin-alpha"
FT /id="PRO_0000034470"
FT CARBOHYD 88
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 197 AA; 21126 MW; 0CF18CC90B5E2345 CRC64;
MTPPGRLYLP LLLGLLLAPP PPGAQGLPGA EFPPSAARNA QQRLQKHFGH STLKPAAHLV
GDPSAQDSLR WRANTDRAFL RHGFSLSNNS LLVPSSGLYF VYSQVVFSGE GCSPKAVPTP
LYLAHEVQLF SSQYSFHVPL LSAQKSVCPG PQGPWVRSVY QGAVFLLTQG DQLSTHTDGI
AHLLLSPSSV FFGAFAL
