ID   AC66_NPVAC              Reviewed;         808 AA.
AC   P41467;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   29-SEP-2021, entry version 50.
DE   RecName: Full=Protein Ac66;
GN   Name=Ac66; ORFNames=ORF66;
OS   Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=46015;
OH   NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C6;
RX   PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA   Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT   "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT   virus.";
RL   Virology 202:586-605(1994).
RN   [2]
RP   FUNCTION.
RX   PubMed=18241908; DOI=10.1016/j.virol.2007.12.033;
RA   Ke J., Wang J., Deng R., Wang X.;
RT   "Autographa californica multiple nucleopolyhedrovirus ac66 is required for
RT   the efficient egress of nucleocapsids from the nucleus, general synthesis
RT   of preoccluded virions and occlusion body formation.";
RL   Virology 374:421-431(2008).
RN   [3]
RP   INTERACTION WITH IE0 AND VUBI, AND SUBCELLULAR LOCATION.
RX   PubMed=29142135; DOI=10.1128/jvi.01713-17;
RA   Biswas S., Willis L.G., Fang M., Nie Y., Theilmann D.A.;
RT   "Autographa californica Nucleopolyhedrovirus AC141 (Exon0), a potential E3
RT   ubiquitin ligase, interacts with viral Ubiquitin and AC66 to facilitate
RT   nucleocapsid egress.";
RL   J. Virol. 92:0-0(2018).
CC   -!- FUNCTION: Plays an essential role in the efficient egress of
CC       nucleocapsids from the host nucleus to the cytoplasm.
CC       {ECO:0000269|PubMed:18241908}.
CC   -!- SUBUNIT: Interacts with the putative E3 ligase IE0 and with viral
CC       ubiquitin/vUbi. {ECO:0000269|PubMed:29142135}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:29142135}. Host
CC       cytoplasm {ECO:0000269|PubMed:29142135}. Note=Localizes mostly in the
CC       ring zone of the host nucleus. Small amounts are observed in the
CC       cytoplasm. {ECO:0000269|PubMed:29142135}.
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DR   EMBL; L22858; AAA66696.1; -; Genomic_DNA.
DR   PIR; C72858; C72858.
DR   RefSeq; NP_054096.1; NC_001623.1.
DR   SMR; P41467; -.
DR   PRIDE; P41467; -.
DR   GeneID; 1403899; -.
DR   KEGG; vg:1403899; -.
DR   Proteomes; UP000008292; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR009615; Desmo_N.
DR   Pfam; PF06771; Desmo_N; 1.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Host nucleus; Reference proteome.
FT   CHAIN           1..808
FT                   /note="Protein Ac66"
FT                   /id="PRO_0000133003"
FT   REGION          132..151
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   808 AA;  93973 MW;  76A871D2B6633F8A CRC64;
     MQRWPKYGGT DVNTRTVHDL LNTINTMSAR IKTLERYEHA LREIHKVVVI LKPSANTHSF
     EPDALPALIM QFLSDFAGRD INTLTHNINY KYDYNYPPAP VPAMQPPPPP PQPPAPPQPP
     YYNNYPYYPP YPFSTPPPTQ PPESNVAGVG GSQSLNQITL TNEEESELAA LFKNMQTNMT
     WELVQNFVEV LIRIVRVHVV NNVTMINVIS SITSVRTLID YNFTEFIRCV YQKTNIRFAI
     DQYLCTNIVT FIDFFTRVFY LVMRTNFQFT TFDQLTQYSN ELYTRIQTSI LQSAAPLSPP
     TVETVNSDIV ISNLQEQLKR ERALMQQISE QHRIANERVE TLQSQYDELD LKYKEIFEDK
     SEFAQQKSEN VRKIKQLERS NKELNDTVQK LRDENAERLS EIQLQKGDLD EYKNMNRQLN
     EDIYKLKRRI ESTFDKDYVE TLNDKIESLE KQLDDKQNLN RELRSSISKI DETTQRYKLD
     AKDIMELKQS VSIKDQEIAM KNAQYLELSA IYQQTVNELT ATKNELSQVA TTNQSLFAEN
     EESKVLLEGT LAFIDSFYQI IMQIEKPDYV PISKPQLTAQ ESIYQTDYIK DWLQKLRSKL
     SNADVANLQS VSELSDLKSQ IISIVPRNIV NRILKENYKV KVENVNAELL ESVAVTSAVS
     ALVQQYERSE KQNVKLRQEF EIKLNDLQRL LEQNQTDFES ISEFISRDPA FNRNLNDERF
     QNLRQQYDEM SSKYSALETT KIKEMESIAD QAVKSEMSKL NTQLDELNSL FVKYNRKAQD
     IFEWKTSMLK RYETLARTTA ASVQPNVE