ID   TNFC_MACMU              Reviewed;         244 AA.
AC   Q5TM22;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Lymphotoxin-beta;
DE            Short=LT-beta;
DE   AltName: Full=Tumor necrosis factor C;
DE            Short=TNF-C;
DE   AltName: Full=Tumor necrosis factor ligand superfamily member 3;
GN   Name=LTB; Synonyms=TNFC, TNFSF3;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15269276; DOI=10.1093/molbev/msh216;
RA   Kulski J.K., Anzai T., Shiina T., Inoko H.;
RT   "Rhesus macaque class I duplicon structures, organization, and evolution
RT   within the alpha block of the major histocompatibility complex.";
RL   Mol. Biol. Evol. 21:2079-2091(2004).
CC   -!- FUNCTION: Cytokine that binds to LTBR/TNFRSF3. May play a specific role
CC       in immune response regulation. Provides the membrane anchor for the
CC       attachment of the heterotrimeric complex to the cell surface (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterotrimer of either two LTB and one LTA subunits or (less
CC       prevalent) two LTA and one LTB subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the tumor necrosis factor family. {ECO:0000305}.
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DR   EMBL; AB128049; BAD69723.1; -; Genomic_DNA.
DR   RefSeq; NP_001040615.1; NM_001047150.1.
DR   AlphaFoldDB; Q5TM22; -.
DR   SMR; Q5TM22; -.
DR   STRING; 9544.ENSMMUP00000011600; -.
DR   GeneID; 715518; -.
DR   KEGG; mcc:715518; -.
DR   CTD; 4050; -.
DR   eggNOG; ENOG502SMSQ; Eukaryota.
DR   HOGENOM; CLU_096531_0_0_1; -.
DR   InParanoid; Q5TM22; -.
DR   OMA; IGAWTTG; -.
DR   OrthoDB; 1338767at2759; -.
DR   TreeFam; TF337780; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   CDD; cd00184; TNF; 1.
DR   Gene3D; 2.60.120.40; -; 1.
DR   InterPro; IPR006053; TNF.
DR   InterPro; IPR002961; TNF_C.
DR   InterPro; IPR021184; TNF_CS.
DR   InterPro; IPR006052; TNF_dom.
DR   InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR   PANTHER; PTHR11471:SF29; PTHR11471:SF29; 1.
DR   Pfam; PF00229; TNF; 1.
DR   PRINTS; PR01234; TNECROSISFCT.
DR   PRINTS; PR01237; TNFC.
DR   SMART; SM00207; TNF; 1.
DR   SUPFAM; SSF49842; SSF49842; 1.
DR   PROSITE; PS00251; TNF_1; 1.
DR   PROSITE; PS50049; TNF_2; 1.
PE   3: Inferred from homology;
KW   Cytokine; Glycoprotein; Membrane; Reference proteome; Signal-anchor;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..244
FT                   /note="Lymphotoxin-beta"
FT                   /id="PRO_0000185488"
FT   TOPO_DOM        1..18
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        19..48
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..244
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        222
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   244 AA;  25259 MW;  46AA5DEEE255B6C2 CRC64;
     MGALGLEGRG GRLQGRGSLL LAVAGATSLV TLLLAVPITV LAVLALVPQD QGGLVTDTAD
     PGAQAQQGLG FQKLPEEEPE ADLSPGLPAA HLIGAPLKGQ GLGWEATKEQ AFLTSGTQFS
     DADGLALPQD GLYYLYCLVG YRGRAPPGGA EPRGRSVTLR SSLYRAGGAY GPGTPELLLE
     GAETVTPVLD PAGRQGYGPL WYTSVGFGGL VQLRRGERVY VNISHPDMVD FARGKTFFGA
     VMVG