ID   TNFC_MARMO              Reviewed;         310 AA.
AC   Q9JM10; Q9JM11;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Lymphotoxin-beta;
DE            Short=LT-beta;
DE   AltName: Full=Tumor necrosis factor C;
DE            Short=TNF-C;
DE   AltName: Full=Tumor necrosis factor ligand superfamily member 3;
GN   Name=LTB; Synonyms=TNFC, TNFSF3;
OS   Marmota monax (Woodchuck).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Marmota.
OX   NCBI_TaxID=9995;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=10721723; DOI=10.1016/s0378-1119(99)00494-1;
RA   Li D.H., Havell E.A., Brown C.L., Cullen J.M.;
RT   "Woodchuck lymphotoxin-alpha, -beta and tumor necrosis factor genes:
RT   structure, characterization and biological activity.";
RL   Gene 242:295-305(2000).
CC   -!- FUNCTION: Cytokine that binds to LTBR/TNFRSF3. May play a specific role
CC       in immune response regulation. Provides the membrane anchor for the
CC       attachment of the heterotrimeric complex to the cell surface.
CC   -!- SUBUNIT: Heterotrimer of either two LTB and one LTA subunits or (less
CC       prevalent) two LTA and one LTB subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the tumor necrosis factor family. {ECO:0000305}.
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DR   EMBL; AF096268; AAF34866.1; -; Genomic_DNA.
DR   EMBL; AF095587; AAF34865.1; -; mRNA.
DR   AlphaFoldDB; Q9JM10; -.
DR   SMR; Q9JM10; -.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   CDD; cd00184; TNF; 1.
DR   Gene3D; 2.60.120.40; -; 1.
DR   InterPro; IPR006053; TNF.
DR   InterPro; IPR002961; TNF_C.
DR   InterPro; IPR006052; TNF_dom.
DR   InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR   PANTHER; PTHR11471:SF29; PTHR11471:SF29; 1.
DR   Pfam; PF00229; TNF; 1.
DR   PRINTS; PR01234; TNECROSISFCT.
DR   PRINTS; PR01237; TNFC.
DR   SMART; SM00207; TNF; 1.
DR   SUPFAM; SSF49842; SSF49842; 1.
DR   PROSITE; PS50049; TNF_2; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Glycoprotein; Membrane; Signal-anchor; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..310
FT                   /note="Lymphotoxin-beta"
FT                   /id="PRO_0000185489"
FT   TOPO_DOM        1..27
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..310
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          67..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        272
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        280
FT                   /note="D -> H (in Ref. 1; AAF34865)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   310 AA;  32644 MW;  73B354EFC8B3B3BE CRC64;
     MGALGLQGRG GRPQGTGCLL LAVAGATSLV TLLLAVPITV LAVLALVPQE QGGLVMESAG
     LGAQAQQGLS KSNGLPSRLH SQIPSSSKNP FLRPGALSSH GKHPWVATLP PIVASTPVPG
     FQQLQEEKPE TDLSSRLPAA HLIGAWMKGQ GLSWEAKKEE AFLRSGTQFS GAEGLALPQD
     GLYYLYCNVG YRGRAPPSGA GPQDRSVTLR SSLYRAGGAY GRGAPELLLE GAETVTPVLD
     RAGRPQYRPL WYTSVGFGGL VQLRRGERVY VNISHPDMVD YRRGKTFFGA VMVGLVPSAS
     LGKCLHSANV