TNFC_MOUSE
ID TNFC_MOUSE Reviewed; 306 AA.
AC P41155;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Lymphotoxin-beta;
DE Short=LT-beta;
DE AltName: Full=Tumor necrosis factor C;
DE Short=TNF-C;
DE AltName: Full=Tumor necrosis factor ligand superfamily member 3;
GN Name=Ltb; Synonyms=Tnfc, Tnfsf3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=7846035; DOI=10.1073/pnas.92.3.674;
RA Pokholok D.K., Maroulakou I.G., Kuprash D.V., Alimzhanov M.B., Kozlov S.V.,
RA Novobrantseva T.I., Turetskaya R.L., Green J.E., Nedospasov S.A.;
RT "Cloning and expression analysis of the murine lymphotoxin beta gene.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:674-678(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=C57BL/6J; TISSUE=Spleen;
RX PubMed=7995944;
RA Lawton P., Nelson J., Tizard R., Browning J.L.;
RT "Characterization of the mouse lymphotoxin-beta gene.";
RL J. Immunol. 154:239-246(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=129;
RX PubMed=14656967; DOI=10.1101/gr.1736803;
RA Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D.,
RA Hood L.;
RT "Analysis of the gene-dense major histocompatibility complex class III
RT region and its comparison to mouse.";
RL Genome Res. 13:2621-2636(2003).
CC -!- FUNCTION: Cytokine that binds to LTBR/TNFRSF3. May play a specific role
CC in immune response regulation. Provides the membrane anchor for the
CC attachment of the heterotrimeric complex to the cell surface.
CC -!- SUBUNIT: Heterotrimer of either two LTB and one LTA subunits or (less
CC prevalent) two LTA and one LTB subunits. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family. {ECO:0000305}.
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DR EMBL; U12029; AAA67716.1; -; Genomic_DNA.
DR EMBL; U16984; AAB60493.1; -; Genomic_DNA.
DR EMBL; U16985; AAA70089.1; -; mRNA.
DR EMBL; U06950; AAA18592.1; -; Unassigned_DNA.
DR EMBL; AF109719; AAC82483.1; -; Genomic_DNA.
DR CCDS; CCDS28690.1; -.
DR PIR; I49139; I49139.
DR RefSeq; NP_032544.1; NM_008518.2.
DR AlphaFoldDB; P41155; -.
DR SMR; P41155; -.
DR BioGRID; 201218; 2.
DR IntAct; P41155; 1.
DR STRING; 10090.ENSMUSP00000025262; -.
DR GlyGen; P41155; 2 sites.
DR iPTMnet; P41155; -.
DR PhosphoSitePlus; P41155; -.
DR EPD; P41155; -.
DR PaxDb; P41155; -.
DR PRIDE; P41155; -.
DR ProteomicsDB; 258790; -.
DR Antibodypedia; 27204; 205 antibodies from 25 providers.
DR DNASU; 16994; -.
DR Ensembl; ENSMUST00000025262; ENSMUSP00000025262; ENSMUSG00000024399.
DR GeneID; 16994; -.
DR KEGG; mmu:16994; -.
DR UCSC; uc008cgp.2; mouse.
DR CTD; 4050; -.
DR MGI; MGI:104796; Ltb.
DR VEuPathDB; HostDB:ENSMUSG00000024399; -.
DR eggNOG; ENOG502SMSQ; Eukaryota.
DR GeneTree; ENSGT01050000244878; -.
DR InParanoid; P41155; -.
DR OMA; IGAWTTG; -.
DR OrthoDB; 1338767at2759; -.
DR PhylomeDB; P41155; -.
DR TreeFam; TF337780; -.
DR Reactome; R-MMU-5668541; TNFR2 non-canonical NF-kB pathway.
DR Reactome; R-MMU-5676594; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.
DR BioGRID-ORCS; 16994; 3 hits in 74 CRISPR screens.
DR PRO; PR:P41155; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; P41155; protein.
DR Bgee; ENSMUSG00000024399; Expressed in spleen and 50 other tissues.
DR ExpressionAtlas; P41155; baseline and differential.
DR Genevisible; P41155; MM.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:MGI.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0010467; P:gene expression; IMP:MGI.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0048535; P:lymph node development; IMP:MGI.
DR GO; GO:0032735; P:positive regulation of interleukin-12 production; IMP:UniProtKB.
DR GO; GO:0043588; P:skin development; IMP:MGI.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR006053; TNF.
DR InterPro; IPR002961; TNF_C.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR11471:SF29; PTHR11471:SF29; 1.
DR Pfam; PF00229; TNF; 1.
DR PRINTS; PR01234; TNECROSISFCT.
DR PRINTS; PR01237; TNFC.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; SSF49842; 1.
DR PROSITE; PS00251; TNF_1; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 2: Evidence at transcript level;
KW Cytokine; Glycoprotein; Membrane; Reference proteome; Signal-anchor;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..306
FT /note="Lymphotoxin-beta"
FT /id="PRO_0000185490"
FT TOPO_DOM 1..27
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..306
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 63..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 127..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 98
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 284
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 306 AA; 32329 MW; B7D276AB84A22549 CRC64;
MGTRGLQGLG GRPQGRGCLL LAVAGATSLV TLLLAVPITV LAVLALVPQD QGRRVEKIIG
SGAQAQKRLD DSKPSCILPS PSSLSETPDP RLHPQRSNAS RNLASTSQGP VAQSSREASA
WMTILSPAAD STPDPGVQQL PKGEPETDLN PELPAAHLIG AWMSGQGLSW EASQEEAFLR
SGAQFSPTHG LALPQDGVYY LYCHVGYRGR TPPAGRSRAR SLTLRSALYR AGGAYGRGSP
ELLLEGAETV TPVVDPIGYG SLWYTSVGFG GLAQLRSGER VYVNISHPDM VDYRRGKTFF
GAVMVG
