ID   TNFC_NOTEU              Reviewed;         250 AA.
AC   Q9XT47;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Lymphotoxin-beta;
DE            Short=LT-beta;
DE   AltName: Full=Tumor necrosis factor C;
DE            Short=TNF-C;
DE   AltName: Full=Tumor necrosis factor ligand superfamily member 3;
GN   Name=LTB; Synonyms=TNFC, TNFSF3;
OS   Notamacropus eugenii (Tammar wallaby) (Macropus eugenii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Diprotodontia; Macropodidae; Notamacropus.
OX   NCBI_TaxID=9315;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Mammary gland;
RX   PubMed=10547148; DOI=10.1089/107999099313028;
RA   Harrison G.A., Deane E.M.;
RT   "cDNA sequence of the lymphotoxin beta chain from a marsupial, Macropus
RT   eugenii (Tammar wallaby).";
RL   J. Interferon Cytokine Res. 19:1099-1102(1999).
CC   -!- FUNCTION: Cytokine that binds to LTBR/TNFRSF3. May play a specific role
CC       in immune response regulation. Provides the membrane anchor for the
CC       attachment of the heterotrimeric complex to the cell surface.
CC   -!- SUBUNIT: Heterotrimer of either two LTB and one LTA subunits or (less
CC       prevalent) two LTA and one LTB subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the tumor necrosis factor family. {ECO:0000305}.
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DR   EMBL; AF119337; AAD41774.1; -; mRNA.
DR   AlphaFoldDB; Q9XT47; -.
DR   SMR; Q9XT47; -.
DR   HOGENOM; CLU_096531_0_0_1; -.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   CDD; cd00184; TNF; 1.
DR   Gene3D; 2.60.120.40; -; 1.
DR   InterPro; IPR006053; TNF.
DR   InterPro; IPR002961; TNF_C.
DR   InterPro; IPR021184; TNF_CS.
DR   InterPro; IPR006052; TNF_dom.
DR   InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR   PANTHER; PTHR11471:SF29; PTHR11471:SF29; 1.
DR   Pfam; PF00229; TNF; 1.
DR   PRINTS; PR01234; TNECROSISFCT.
DR   PRINTS; PR01237; TNFC.
DR   SMART; SM00207; TNF; 1.
DR   SUPFAM; SSF49842; SSF49842; 1.
DR   PROSITE; PS00251; TNF_1; 1.
DR   PROSITE; PS50049; TNF_2; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Glycoprotein; Membrane; Signal-anchor; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..250
FT                   /note="Lymphotoxin-beta"
FT                   /id="PRO_0000185487"
FT   TOPO_DOM        1..26
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        27..47
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        48..250
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        228
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   250 AA;  26143 MW;  AD37FB975452FE84 CRC64;
     MGAPGLETRA GGPNGKSYLL LASVGAAVLG TLLLSVPITV LTVLALMPQE QGGQVADPSG
     PGGQLLQQLG FHKLPVESRS DLSPIPPAAH LIGIAKSSHG LRWVSGYEEA FLKSGTQFLG
     DEGLLALPQD GIYFLYCHIG YRGRAPSGGE QFRSQAGDPG VPVTLSSQLF RARGASGSGE
     PELLLQGFET VTPPVQHARG VGQGPLWYAT VGFGGLVQLR GGEKIYVNVS HLELVDFRRG
     KTFFGAVMVG