TNFC_PANTR
ID TNFC_PANTR Reviewed; 244 AA.
AC Q862Z7; Q1XHZ4;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Lymphotoxin-beta;
DE Short=LT-beta;
DE AltName: Full=Tumor necrosis factor C;
DE Short=TNF-C;
DE AltName: Full=Tumor necrosis factor ligand superfamily member 3;
GN Name=LTB; Synonyms=TNFC, TNFSF3;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12493009; DOI=10.1034/j.1600-065x.2002.19008.x;
RA Kulski J.K., Shiina T., Anzai T., Kohara S., Inoko H.;
RT "Comparative genomic analysis of the MHC: the evolution of class I
RT duplication blocks, diversity and complexity from shark to man.";
RL Immunol. Rev. 190:95-122(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12799463; DOI=10.1073/pnas.1230533100;
RA Anzai T., Shiina T., Kimura N., Yanagiya K., Kohara S., Shigenari A.,
RA Yamagata T., Kulski J.K., Naruse T.K., Fujimori Y., Fukuzumi Y.,
RA Yamazaki M., Tashiro H., Iwamoto C., Umehara Y., Imanishi T., Meyer A.,
RA Ikeo K., Gojobori T., Bahram S., Inoko H.;
RT "Comparative sequencing of human and chimpanzee MHC class I regions unveils
RT insertions/deletions as the major path to genomic divergence.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7708-7713(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16702430; DOI=10.1534/genetics.106.057034;
RA Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M.,
RA Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K.,
RA Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A.,
RA Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T.,
RA Inoko H., Bahram S.;
RT "Rapid evolution of major histocompatibility complex class I genes in
RT primates generates new disease alleles in humans via hitchhiking
RT diversity.";
RL Genetics 173:1555-1570(2006).
CC -!- FUNCTION: Cytokine that binds to LTBR/TNFRSF3. May play a specific role
CC in immune response regulation. Provides the membrane anchor for the
CC attachment of the heterotrimeric complex to the cell surface (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterotrimer of either two LTB and one LTA subunits or (less
CC prevalent) two LTA and one LTB subunits. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family. {ECO:0000305}.
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DR EMBL; AB054536; BAB83881.1; -; Genomic_DNA.
DR EMBL; BA000041; BAC78156.1; -; Genomic_DNA.
DR EMBL; AB210168; BAE92776.1; -; Genomic_DNA.
DR EMBL; AB210167; BAE92775.1; -; Genomic_DNA.
DR RefSeq; NP_001070252.1; NM_001076784.1.
DR AlphaFoldDB; Q862Z7; -.
DR SMR; Q862Z7; -.
DR STRING; 9598.ENSPTRP00000050396; -.
DR PaxDb; Q862Z7; -.
DR Ensembl; ENSPTRT00000033177; ENSPTRP00000050396; ENSPTRG00000017966.
DR GeneID; 744486; -.
DR KEGG; ptr:744486; -.
DR CTD; 4050; -.
DR VGNC; VGNC:11107; LTB.
DR eggNOG; ENOG502SMSQ; Eukaryota.
DR GeneTree; ENSGT01050000244878; -.
DR HOGENOM; CLU_096531_0_0_1; -.
DR InParanoid; Q862Z7; -.
DR OMA; IGAWTTG; -.
DR OrthoDB; 1338767at2759; -.
DR TreeFam; TF337780; -.
DR Proteomes; UP000002277; Chromosome 6.
DR Bgee; ENSPTRG00000017966; Expressed in thymus and 16 other tissues.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0010467; P:gene expression; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0048535; P:lymph node development; IEA:Ensembl.
DR GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
DR GO; GO:0043588; P:skin development; IEA:Ensembl.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR006053; TNF.
DR InterPro; IPR002961; TNF_C.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR11471:SF29; PTHR11471:SF29; 1.
DR Pfam; PF00229; TNF; 1.
DR PRINTS; PR01234; TNECROSISFCT.
DR PRINTS; PR01237; TNFC.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; SSF49842; 1.
DR PROSITE; PS00251; TNF_1; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Cytokine; Glycoprotein; Membrane; Reference proteome; Signal-anchor;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..244
FT /note="Lymphotoxin-beta"
FT /id="PRO_0000185491"
FT TOPO_DOM 1..18
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 19..48
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..244
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT CARBOHYD 222
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 244 AA; 25420 MW; A4047858335D5B97 CRC64;
MGALGLEGRG GRLQGRGSLL LAVAGATSLV TLLLAVPITV LAVLALVPQD QGGLVTETAD
PGAQAQQGLG FQKLPEEEPE TDLSPGLPAA HLIGAPLKGQ GLGWETTKEQ AFLTSGTQFS
DAEGLALPQD GLYYLYCLVG YRGRTPPGGG DPQGRSVTLR SSLYRAGGAY GPGTPELLLE
GAETVTPVLD PARRQGYGPL WYTSVGFGGL VQLRRGERVY VNISHPDMVD FARGKTFFGA
VMVG
