ID   TNFC_PIG                Reviewed;         150 AA.
AC   Q9TSV8;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Lymphotoxin-beta;
DE            Short=LT-beta;
DE   AltName: Full=Tumor necrosis factor C;
DE            Short=TNF-C;
DE   AltName: Full=Tumor necrosis factor ligand superfamily member 3;
DE   Flags: Fragment;
GN   Name=LTB; Synonyms=TNFC, TNFSF3;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Large white; TISSUE=Fibroblast;
RX   PubMed=11169259; DOI=10.1034/j.1399-0039.2001.057001055.x;
RA   Chardon P., Rogel-Gaillard C., Cattolico L., Duprat S., Vaiman M.,
RA   Renard C.;
RT   "Sequence of the swine major histocompatibility complex region containing
RT   all non-classical class I genes.";
RL   Tissue Antigens 57:55-65(2001).
CC   -!- FUNCTION: Cytokine that binds to LTBR/TNFRSF3. May play a specific role
CC       in immune response regulation. Provides the membrane anchor for the
CC       attachment of the heterotrimeric complex to the cell surface.
CC   -!- SUBUNIT: Heterotrimer of either two LTB and one LTA subunits or (less
CC       prevalent) two LTA and one LTB subunits.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type II
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the tumor necrosis factor family. {ECO:0000305}.
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DR   EMBL; AJ251914; CAB63851.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9TSV8; -.
DR   SMR; Q9TSV8; -.
DR   STRING; 9823.ENSSSCP00000001493; -.
DR   eggNOG; ENOG502SMSQ; Eukaryota.
DR   HOGENOM; CLU_096531_0_0_1; -.
DR   InParanoid; Q9TSV8; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   Genevisible; Q9TSV8; SS.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0032735; P:positive regulation of interleukin-12 production; ISS:UniProtKB.
DR   CDD; cd00184; TNF; 1.
DR   Gene3D; 2.60.120.40; -; 1.
DR   InterPro; IPR006053; TNF.
DR   InterPro; IPR002961; TNF_C.
DR   InterPro; IPR021184; TNF_CS.
DR   InterPro; IPR006052; TNF_dom.
DR   InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR   PANTHER; PTHR11471:SF29; PTHR11471:SF29; 1.
DR   Pfam; PF00229; TNF; 1.
DR   PRINTS; PR01234; TNECROSISFCT.
DR   PRINTS; PR01237; TNFC.
DR   SMART; SM00207; TNF; 1.
DR   SUPFAM; SSF49842; SSF49842; 1.
DR   PROSITE; PS00251; TNF_1; 1.
DR   PROSITE; PS50049; TNF_2; 1.
PE   3: Inferred from homology;
KW   Cytokine; Glycoprotein; Membrane; Reference proteome.
FT   CHAIN           <1..150
FT                   /note="Lymphotoxin-beta"
FT                   /id="PRO_0000185492"
FT   CARBOHYD        128
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
SQ   SEQUENCE   150 AA;  16423 MW;  FE5C4CC657658B48 CRC64;
     AWITGQGLGW EAKKEEAFLR SGTQFSGAEG LALPQDGLYY LYCHVGYRGR APPPGGDPLD
     RSVTLLSRLY RAGGAYGPGT PELLLEGAET VTPVLDPSRR HEYGPLWYTS VGFGGLVQLR
     RGERVYVNIS HPDMVDYRRG KTFFGAVMVG