TNFL4_RAT
ID TNFL4_RAT Reviewed; 199 AA.
AC Q9Z2P3;
DT 06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Tumor necrosis factor ligand superfamily member 4;
DE AltName: Full=OX40 ligand;
DE Short=OX40L;
DE AltName: CD_antigen=CD252;
GN Name=Tnfsf4; Synonyms=Ox40l, Txgp1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=T-cell lymphoma;
RX PubMed=9790919; DOI=10.1006/bbrc.1998.9376;
RA Akiba H., Atsuta M., Yagita H., Okumura K.;
RT "Identification of rat OX40 ligand by molecular cloning.";
RL Biochem. Biophys. Res. Commun. 251:131-136(1998).
CC -!- FUNCTION: Cytokine that binds to TNFRSF4. Co-stimulates T-cell
CC proliferation and cytokine production (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
CC -!- TISSUE SPECIFICITY: Detected in T-cell lines, but not in a macrophage
CC cell line.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family. {ECO:0000305}.
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DR EMBL; AF037067; AAC67236.1; -; mRNA.
DR PIR; JE0351; JE0351.
DR RefSeq; NP_446004.1; NM_053552.1.
DR AlphaFoldDB; Q9Z2P3; -.
DR SMR; Q9Z2P3; -.
DR STRING; 10116.ENSRNOP00000003969; -.
DR GlyGen; Q9Z2P3; 2 sites.
DR PaxDb; Q9Z2P3; -.
DR Ensembl; ENSRNOT00000003969; ENSRNOP00000003969; ENSRNOG00000002968.
DR GeneID; 89814; -.
DR KEGG; rno:89814; -.
DR UCSC; RGD:619816; rat.
DR CTD; 7292; -.
DR RGD; 619816; Tnfsf4.
DR eggNOG; ENOG502ST4X; Eukaryota.
DR GeneTree; ENSGT00390000015127; -.
DR HOGENOM; CLU_091735_0_0_1; -.
DR InParanoid; Q9Z2P3; -.
DR OMA; NTSCEDF; -.
DR OrthoDB; 1590205at2759; -.
DR PhylomeDB; Q9Z2P3; -.
DR TreeFam; TF336384; -.
DR Reactome; R-RNO-5669034; TNFs bind their physiological receptors.
DR PRO; PR:Q9Z2P3; -.
DR Proteomes; UP000002494; Chromosome 13.
DR Bgee; ENSRNOG00000002968; Expressed in thymus.
DR ExpressionAtlas; Q9Z2P3; baseline and differential.
DR Genevisible; Q9Z2P3; RN.
DR GO; GO:0009986; C:cell surface; IDA:RGD.
DR GO; GO:0005615; C:extracellular space; ISO:RGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; ISO:RGD.
DR GO; GO:0032813; F:tumor necrosis factor receptor superfamily binding; IMP:RGD.
DR GO; GO:0002526; P:acute inflammatory response; ISO:RGD.
DR GO; GO:0035783; P:CD4-positive, alpha-beta T cell costimulation; ISO:RGD.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; ISO:RGD.
DR GO; GO:0035714; P:cellular response to nitrogen dioxide; ISO:RGD.
DR GO; GO:0071380; P:cellular response to prostaglandin E stimulus; ISO:RGD.
DR GO; GO:0008203; P:cholesterol metabolic process; ISO:RGD.
DR GO; GO:0002215; P:defense response to nematode; ISO:RGD.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; ISO:RGD.
DR GO; GO:0035709; P:memory T cell activation; ISO:RGD.
DR GO; GO:0001818; P:negative regulation of cytokine production; ISO:RGD.
DR GO; GO:0043433; P:negative regulation of DNA-binding transcription factor activity; ISO:RGD.
DR GO; GO:0032689; P:negative regulation of interferon-gamma production; ISO:RGD.
DR GO; GO:0032700; P:negative regulation of interleukin-17 production; ISO:RGD.
DR GO; GO:0045590; P:negative regulation of regulatory T cell differentiation; ISO:RGD.
DR GO; GO:0045626; P:negative regulation of T-helper 1 cell differentiation; ISO:RGD.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:RGD.
DR GO; GO:0042104; P:positive regulation of activated T cell proliferation; IDA:RGD.
DR GO; GO:0046641; P:positive regulation of alpha-beta T cell proliferation; ISO:RGD.
DR GO; GO:0050871; P:positive regulation of B cell activation; ISO:RGD.
DR GO; GO:1900281; P:positive regulation of CD4-positive, alpha-beta T cell costimulation; ISO:RGD.
DR GO; GO:0043372; P:positive regulation of CD4-positive, alpha-beta T cell differentiation; ISO:RGD.
DR GO; GO:0032722; P:positive regulation of chemokine production; ISO:RGD.
DR GO; GO:0001819; P:positive regulation of cytokine production; IBA:GO_Central.
DR GO; GO:0002891; P:positive regulation of immunoglobulin mediated immune response; ISO:RGD.
DR GO; GO:0002639; P:positive regulation of immunoglobulin production; ISO:RGD.
DR GO; GO:0050729; P:positive regulation of inflammatory response; ISO:RGD.
DR GO; GO:0032729; P:positive regulation of interferon-gamma production; ISO:RGD.
DR GO; GO:0032733; P:positive regulation of interleukin-10 production; ISO:RGD.
DR GO; GO:0032735; P:positive regulation of interleukin-12 production; ISO:RGD.
DR GO; GO:0032736; P:positive regulation of interleukin-13 production; ISO:RGD.
DR GO; GO:0032743; P:positive regulation of interleukin-2 production; IDA:RGD.
DR GO; GO:0032753; P:positive regulation of interleukin-4 production; ISO:RGD.
DR GO; GO:2000572; P:positive regulation of interleukin-4-dependent isotype switching to IgE isotypes; ISO:RGD.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; ISO:RGD.
DR GO; GO:2000568; P:positive regulation of memory T cell activation; ISO:RGD.
DR GO; GO:0043382; P:positive regulation of memory T cell differentiation; ISO:RGD.
DR GO; GO:2000525; P:positive regulation of T cell costimulation; ISO:RGD.
DR GO; GO:0002726; P:positive regulation of T cell cytokine production; ISO:RGD.
DR GO; GO:0042102; P:positive regulation of T cell proliferation; IBA:GO_Central.
DR GO; GO:2000570; P:positive regulation of T-helper 2 cell activation; ISO:RGD.
DR GO; GO:0045630; P:positive regulation of T-helper 2 cell differentiation; ISO:RGD.
DR GO; GO:0002830; P:positive regulation of type 2 immune response; ISO:RGD.
DR GO; GO:0002819; P:regulation of adaptive immune response; ISO:RGD.
DR GO; GO:0050727; P:regulation of inflammatory response; ISO:RGD.
DR GO; GO:0035713; P:response to nitrogen dioxide; ISO:RGD.
DR GO; GO:0009615; P:response to virus; ISO:RGD.
DR GO; GO:0042098; P:T cell proliferation; IMP:RGD.
DR GO; GO:0035712; P:T-helper 2 cell activation; ISO:RGD.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR042338; TNFSF4.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR17534; PTHR17534; 1.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; SSF49842; 1.
DR PROSITE; PS00251; TNF_1; 1.
PE 2: Evidence at transcript level;
KW Cytokine; Disulfide bond; Glycoprotein; Membrane; Reference proteome;
KW Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..199
FT /note="Tumor necrosis factor ligand superfamily member 4"
FT /id="PRO_0000185496"
FT TOPO_DOM 1..25
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..48
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..199
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT CARBOHYD 91
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 157
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 70..163
FT /evidence="ECO:0000250"
FT DISULFID 98..184
FT /evidence="ECO:0000250"
SQ SEQUENCE 199 AA; 22190 MW; 0032C901CC62B0FA CRC64;
MEGEGVQPPD ENLENGSRPR FKWKKVLRLV VSGIKAAGLL LCVVYVCLQF SSSPAKDSPI
QRLRAPVTGC EGGRLFIGTS KNEYETMEVQ NNSVIINCDG LYLIHLKGSF FQEVKINLHF
RKDRSPIFVP MLNNGQRVVF TVVTSLAFKD EVYLTVNASD TLCEHLQIND GELIIVQLTP
NGYCAPERPY SSTVNQVPL
