BTD_DROME
ID BTD_DROME Reviewed; 644 AA.
AC Q24266; Q9W319;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Transcription factor btd;
DE AltName: Full=Protein buttonhead;
GN Name=btd; ORFNames=CG12653;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Canton-S; TISSUE=Embryo;
RX PubMed=8259212; DOI=10.1038/366690a0;
RA Wimmer E.A., Jaeckle H., Pfeifle C., Cohen S.M.;
RT "A Drosophila homologue of human Sp1 is a head-specific segmentation
RT gene.";
RL Nature 366:690-694(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- FUNCTION: Required for the development of the antennal, intercalary and
CC mandibular segments of the head.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: First expressed in a stripe covering the head
CC anlagen of the syncytial blastoderm embryo, persists through
CC gastrulation and decays during germ band extension. Expressed later in
CC development in a complex spatially restricted pattern.
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DR EMBL; Z29361; CAA82545.1; -; Genomic_DNA.
DR EMBL; AE014298; AAF46518.1; -; Genomic_DNA.
DR RefSeq; NP_511100.1; NM_078545.3.
DR AlphaFoldDB; Q24266; -.
DR SMR; Q24266; -.
DR BioGRID; 58350; 13.
DR DIP; DIP-20818N; -.
DR IntAct; Q24266; 8.
DR STRING; 7227.FBpp0071314; -.
DR PaxDb; Q24266; -.
DR EnsemblMetazoa; FBtr0071379; FBpp0071314; FBgn0000233.
DR GeneID; 31912; -.
DR KEGG; dme:Dmel_CG12653; -.
DR UCSC; CG12653-RA; d. melanogaster.
DR CTD; 686; -.
DR FlyBase; FBgn0000233; btd.
DR VEuPathDB; VectorBase:FBgn0000233; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000165792; -.
DR HOGENOM; CLU_369312_0_0_1; -.
DR InParanoid; Q24266; -.
DR OMA; HYAALAM; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q24266; -.
DR SignaLink; Q24266; -.
DR BioGRID-ORCS; 31912; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 31912; -.
DR PRO; PR:Q24266; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0000233; Expressed in ectoderm and 57 other tissues.
DR Genevisible; Q24266; DM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:FlyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:FlyBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:FlyBase.
DR GO; GO:0008134; F:transcription factor binding; IPI:FlyBase.
DR GO; GO:0035288; P:anterior head segmentation; TAS:FlyBase.
DR GO; GO:0007376; P:cephalic furrow formation; IMP:FlyBase.
DR GO; GO:0007480; P:imaginal disc-derived leg morphogenesis; IMP:FlyBase.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:FlyBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:FlyBase.
DR GO; GO:0035289; P:posterior head segmentation; TAS:FlyBase.
DR GO; GO:1902692; P:regulation of neuroblast proliferation; IGI:UniProtKB.
DR GO; GO:0045664; P:regulation of neuron differentiation; IGI:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..644
FT /note="Transcription factor btd"
FT /id="PRO_0000046910"
FT ZN_FING 333..357
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 363..385
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 391..413
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 16..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 101..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 437..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 478..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 644 AA; 68581 MW; A0DB98C2AF938452 CRC64;
MIDAACNYLN PYAQQHQAQQ QQHAQHQQHA QQQQHHLHMQ QAQHHLHLSH QQAQQQHMQH
LTQQQQQQQQ QQQQQQQQQQ QQQQPQQQQH DFLSAAALLS APPSLSGSSS GSSSGSSPLY
GKPPMKLELP YPQASSTGTA SPNSSIQSAP SSASVSPSIF PSPAQSFASI SASPSTPTTT
LAPPTTAAAG ALAGSPTSSS PSSSAASAAA AAAAAAAAAA DLGAAAVASA AYGWNTAYSG
LGPARSQFPY AQYASDYYGN AVGMSSSAAW FSHQERLYQP WSSQSYPGFN FDDIAFQTQL
QRRSVRCTCP NCTNEMSGLP PIVGPDERGR KQHICHIPGC ERLYGKASHL KTHLRWHTGE
RPFLCLTCGK RFSRSDELQR HGRTHTNYRP YACPICSKKF SRSDHLSKHK KTHFKDKKSK
KVLAAEAKEQ AAAAIKLEKK EKKSGKPLTP PVEFKQEQPD TTPLVNYAPY ANLYQHSTSA
GSSVNPPPPP PPLFQQQMTT TTSSAAASFV EQPWSSSSSR AIQPATTSAS SSSSSSASSP
AAAVVSAIGS ASSPAASATA LAQHHYAALA MQSESQLAAE YGLTMSGLAS GASQDSSSSC
HMKSEYAASY PADFGAGTAS YGYPHPHPHH HNAWAAAYHP HATA
