TNFL8_HUMAN
ID TNFL8_HUMAN Reviewed; 234 AA.
AC P32971; O43404;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Tumor necrosis factor ligand superfamily member 8;
DE AltName: Full=CD30 ligand;
DE Short=CD30-L;
DE AltName: CD_antigen=CD153;
GN Name=TNFSF8; Synonyms=CD30L, CD30LG;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8391931; DOI=10.1016/0092-8674(93)90361-s;
RA Smith C.A., Gruess H.-J., Davis T., Anderson D., Farrah T., Baker E.,
RA Sutherland G.R., Brannan C.I., Copeland N.G., Jenkins N.A., Grabstein K.H.,
RA Gliniak B., McAlister I.B., Fanslow W., Alderson M., Falk B., Gimpsel S.,
RA Gillis S., Din W.S., Goodwin R.G., Armitage R.J.;
RT "CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand
RT defines an emerging family of cytokines with homology to TNF.";
RL Cell 73:1349-1360(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9349718; DOI=10.1016/s0167-4781(97)00108-5;
RA Croager E.J., Abraham L.J.;
RT "Characterisation of the human CD30 ligand gene structure.";
RL Biochim. Biophys. Acta 1353:231-235(1997).
CC -!- FUNCTION: Cytokine that binds to TNFRSF8/CD30. Induces proliferation of
CC T-cells.
CC -!- SUBUNIT: Homotrimer. {ECO:0000305}.
CC -!- INTERACTION:
CC P32971; O95393: BMP10; NbExp=3; IntAct=EBI-13076860, EBI-3922513;
CC P32971; Q07325: CXCL9; NbExp=3; IntAct=EBI-13076860, EBI-3911467;
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family. {ECO:0000305}.
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DR EMBL; L09753; AAA74594.1; -; mRNA.
DR EMBL; AF006384; AAB97877.1; -; Genomic_DNA.
DR EMBL; AF006381; AAB97877.1; JOINED; Genomic_DNA.
DR EMBL; AF006382; AAB97877.1; JOINED; Genomic_DNA.
DR EMBL; AF006383; AAB97877.1; JOINED; Genomic_DNA.
DR CCDS; CCDS6810.1; -.
DR PIR; A40710; A40710.
DR RefSeq; NP_001235.1; NM_001244.3.
DR AlphaFoldDB; P32971; -.
DR SMR; P32971; -.
DR BioGRID; 107382; 170.
DR DIP; DIP-2929N; -.
DR IntAct; P32971; 38.
DR STRING; 9606.ENSP00000223795; -.
DR GlyGen; P32971; 5 sites.
DR iPTMnet; P32971; -.
DR PhosphoSitePlus; P32971; -.
DR BioMuta; TNFSF8; -.
DR DMDM; 416777; -.
DR MassIVE; P32971; -.
DR PaxDb; P32971; -.
DR PeptideAtlas; P32971; -.
DR PRIDE; P32971; -.
DR ProteomicsDB; 54895; -.
DR Antibodypedia; 15592; 444 antibodies from 30 providers.
DR DNASU; 944; -.
DR Ensembl; ENST00000223795.3; ENSP00000223795.2; ENSG00000106952.8.
DR GeneID; 944; -.
DR KEGG; hsa:944; -.
DR MANE-Select; ENST00000223795.3; ENSP00000223795.2; NM_001244.4; NP_001235.1.
DR CTD; 944; -.
DR DisGeNET; 944; -.
DR GeneCards; TNFSF8; -.
DR HGNC; HGNC:11938; TNFSF8.
DR HPA; ENSG00000106952; Tissue enhanced (bone marrow, lymphoid tissue).
DR MIM; 603875; gene.
DR neXtProt; NX_P32971; -.
DR OpenTargets; ENSG00000106952; -.
DR PharmGKB; PA36628; -.
DR VEuPathDB; HostDB:ENSG00000106952; -.
DR eggNOG; ENOG502S54A; Eukaryota.
DR GeneTree; ENSGT00390000011719; -.
DR HOGENOM; CLU_102229_0_0_1; -.
DR InParanoid; P32971; -.
DR OMA; FLVQCSN; -.
DR OrthoDB; 1469711at2759; -.
DR PhylomeDB; P32971; -.
DR TreeFam; TF335780; -.
DR PathwayCommons; P32971; -.
DR Reactome; R-HSA-5669034; TNFs bind their physiological receptors.
DR SignaLink; P32971; -.
DR BioGRID-ORCS; 944; 6 hits in 1068 CRISPR screens.
DR ChiTaRS; TNFSF8; human.
DR GenomeRNAi; 944; -.
DR Pharos; P32971; Tbio.
DR PRO; PR:P32971; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; P32971; protein.
DR Bgee; ENSG00000106952; Expressed in monocyte and 111 other tissues.
DR ExpressionAtlas; P32971; baseline and differential.
DR Genevisible; P32971; HS.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; TAS:ProtInc.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0043374; P:CD8-positive, alpha-beta T cell differentiation; IBA:GO_Central.
DR GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0042129; P:regulation of T cell proliferation; TAS:GO_Central.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR021185; TNF_CD30_ligand_type.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR Pfam; PF00229; TNF; 1.
DR PIRSF; PIRSF019548; TNF_CD30_ligand_type; 1.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; SSF49842; 1.
DR PROSITE; PS00251; TNF_1; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 1: Evidence at protein level;
KW Cytokine; Disulfide bond; Glycoprotein; Membrane; Reference proteome;
KW Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..234
FT /note="Tumor necrosis factor ligand superfamily member 8"
FT /id="PRO_0000185499"
FT TOPO_DOM 1..37
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..62
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..234
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT CARBOHYD 81
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 109
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 153
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 189
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 201
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 151..177
FT /evidence="ECO:0000255"
SQ SEQUENCE 234 AA; 26017 MW; C653615682305B1B CRC64;
MDPGLQQALN GMAPPGDTAM HVPAGSVASH LGTTSRSYFY LTTATLALCL VFTVATIMVL
VVQRTDSIPN SPDNVPLKGG NCSEDLLCIL KRAPFKKSWA YLQVAKHLNK TKLSWNKDGI
LHGVRYQDGN LVIQFPGLYF IICQLQFLVQ CPNNSVDLKL ELLINKHIKK QALVTVCESG
MQTKHVYQNL SQFLLDYLQV NTTISVNVDT FQYIDTSTFP LENVLSIFLY SNSD
