TNFL8_MOUSE
ID TNFL8_MOUSE Reviewed; 239 AA.
AC P32972;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Tumor necrosis factor ligand superfamily member 8;
DE AltName: Full=CD30 ligand;
DE Short=CD30-L;
DE AltName: CD_antigen=CD153;
GN Name=Tnfsf8; Synonyms=Cd30l, Cd30lg;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=T-cell;
RX PubMed=8391931; DOI=10.1016/0092-8674(93)90361-s;
RA Smith C.A., Gruess H.-J., Davis T., Anderson D., Farrah T., Baker E.,
RA Sutherland G.R., Brannan C.I., Copeland N.G., Jenkins N.A., Grabstein K.H.,
RA Gliniak B., McAlister I.B., Fanslow W., Alderson M., Falk B., Gimpsel S.,
RA Gillis S., Din W.S., Goodwin R.G., Armitage R.J.;
RT "CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand
RT defines an emerging family of cytokines with homology to TNF.";
RL Cell 73:1349-1360(1993).
CC -!- FUNCTION: Cytokine that binds to TNFRSF8/CD30. Induces proliferation of
CC T-cells.
CC -!- SUBUNIT: Homotrimer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family. {ECO:0000305}.
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DR EMBL; L09754; AAA74595.1; -; mRNA.
DR CCDS; CCDS18264.1; -.
DR PIR; B40710; B40710.
DR RefSeq; NP_033429.1; NM_009403.3.
DR AlphaFoldDB; P32972; -.
DR SMR; P32972; -.
DR STRING; 10090.ENSMUSP00000030047; -.
DR GlyGen; P32972; 6 sites.
DR PhosphoSitePlus; P32972; -.
DR PaxDb; P32972; -.
DR PRIDE; P32972; -.
DR Antibodypedia; 15592; 444 antibodies from 30 providers.
DR DNASU; 21949; -.
DR Ensembl; ENSMUST00000030047; ENSMUSP00000030047; ENSMUSG00000028362.
DR GeneID; 21949; -.
DR KEGG; mmu:21949; -.
DR UCSC; uc008thd.1; mouse.
DR CTD; 944; -.
DR MGI; MGI:88328; Tnfsf8.
DR VEuPathDB; HostDB:ENSMUSG00000028362; -.
DR eggNOG; ENOG502S54A; Eukaryota.
DR GeneTree; ENSGT00390000011719; -.
DR HOGENOM; CLU_102229_0_0_1; -.
DR InParanoid; P32972; -.
DR OMA; FLVQCSN; -.
DR OrthoDB; 1469711at2759; -.
DR PhylomeDB; P32972; -.
DR TreeFam; TF335780; -.
DR Reactome; R-MMU-5669034; TNFs bind their physiological receptors.
DR BioGRID-ORCS; 21949; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Tnfsf8; mouse.
DR PRO; PR:P32972; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; P32972; protein.
DR Bgee; ENSMUSG00000028362; Expressed in kidney vasculature and 17 other tissues.
DR ExpressionAtlas; P32972; baseline and differential.
DR Genevisible; P32972; MM.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0043374; P:CD8-positive, alpha-beta T cell differentiation; IMP:MGI.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IMP:MGI.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR021185; TNF_CD30_ligand_type.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR Pfam; PF00229; TNF; 1.
DR PIRSF; PIRSF019548; TNF_CD30_ligand_type; 1.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; SSF49842; 1.
DR PROSITE; PS00251; TNF_1; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 2: Evidence at transcript level;
KW Cytokine; Disulfide bond; Glycoprotein; Membrane; Reference proteome;
KW Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..239
FT /note="Tumor necrosis factor ligand superfamily member 8"
FT /id="PRO_0000185500"
FT TOPO_DOM 1..43
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..67
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..239
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 75
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 86
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 114
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 158
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 194
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 206
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 156..182
FT /evidence="ECO:0000255"
SQ SEQUENCE 239 AA; 26519 MW; 29003157DD425159 CRC64;
MEPGLQQAGS CGAPSPDPAM QVQPGSVASP WRSTRPWRST SRSYFYLSTT ALVCLVVAVA
IILVLVVQKK DSTPNTTEKA PLKGGNCSED LFCTLKSTPS KKSWAYLQVS KHLNNTKLSW
NEDGTIHGLI YQDGNLIVQF PGLYFIVCQL QFLVQCSNHS VDLTLQLLIN SKIKKQTLVT
VCESGVQSKN IYQNLSQFLL HYLQVNSTIS VRVDNFQYVD TNTFPLDNVL SVFLYSSSD
