TNG2_DROME
ID TNG2_DROME Reviewed; 283 AA.
AC Q9VYA8; C6SV10; Q8T0H6;
DT 06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Transport and Golgi organization protein 2;
GN Name=Tango2; ORFNames=CG11176;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=Berkeley;
RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=16452979; DOI=10.1038/nature04377;
RA Bard F., Casano L., Mallabiabarrena A., Wallace E., Saito K., Kitayama H.,
RA Guizzunti G., Hu Y., Wendler F., Dasgupta R., Perrimon N., Malhotra V.;
RT "Functional genomics reveals genes involved in protein secretion and Golgi
RT organization.";
RL Nature 439:604-607(2006).
CC -!- FUNCTION: May play a role in Golgi organization.
CC {ECO:0000269|PubMed:16452979}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16452979}.
CC Mitochondrion {ECO:0000250|UniProtKB:P54797}. Golgi apparatus
CC {ECO:0000269|PubMed:16452979}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9VYA8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9VYA8-2; Sequence=VSP_045448;
CC -!- SIMILARITY: Belongs to the Tango2 family. {ECO:0000305}.
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DR EMBL; AE014298; AAF48295.2; -; Genomic_DNA.
DR EMBL; AY069312; AAL39457.1; -; mRNA.
DR EMBL; BT089002; ACT88143.1; -; mRNA.
DR RefSeq; NP_001245654.1; NM_001258725.2. [Q9VYA8-2]
DR RefSeq; NP_001259525.1; NM_001272596.1. [Q9VYA8-1]
DR RefSeq; NP_001285217.1; NM_001298288.1. [Q9VYA8-2]
DR RefSeq; NP_572905.1; NM_132677.4. [Q9VYA8-1]
DR AlphaFoldDB; Q9VYA8; -.
DR BioGRID; 58696; 26.
DR IntAct; Q9VYA8; 3.
DR PRIDE; Q9VYA8; -.
DR DNASU; 32319; -.
DR EnsemblMetazoa; FBtr0073807; FBpp0073638; FBgn0030503. [Q9VYA8-1]
DR EnsemblMetazoa; FBtr0308644; FBpp0300867; FBgn0030503. [Q9VYA8-2]
DR EnsemblMetazoa; FBtr0331722; FBpp0304111; FBgn0030503. [Q9VYA8-1]
DR EnsemblMetazoa; FBtr0340395; FBpp0309341; FBgn0030503. [Q9VYA8-2]
DR GeneID; 32319; -.
DR KEGG; dme:Dmel_CG11176; -.
DR UCSC; CG11176-RA; d. melanogaster. [Q9VYA8-1]
DR CTD; 128989; -.
DR FlyBase; FBgn0030503; Tango2.
DR VEuPathDB; VectorBase:FBgn0030503; -.
DR GeneTree; ENSGT00390000012733; -.
DR HOGENOM; CLU_047037_3_2_1; -.
DR InParanoid; Q9VYA8; -.
DR OMA; TFTERNM; -.
DR PhylomeDB; Q9VYA8; -.
DR BioGRID-ORCS; 32319; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 32319; -.
DR PRO; PR:Q9VYA8; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0030503; Expressed in adult Malpighian tubule (Drosophila) and 23 other tissues.
DR ExpressionAtlas; Q9VYA8; baseline and differential.
DR Genevisible; Q9VYA8; DM.
DR GO; GO:0005829; C:cytosol; IDA:FlyBase.
DR GO; GO:0005794; C:Golgi apparatus; IDA:FlyBase.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0007030; P:Golgi organization; IMP:FlyBase.
DR GO; GO:0009306; P:protein secretion; IMP:FlyBase.
DR InterPro; IPR008551; TANGO2.
DR PANTHER; PTHR17985; PTHR17985; 1.
DR Pfam; PF05742; TANGO2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Golgi apparatus; Mitochondrion;
KW Reference proteome.
FT CHAIN 1..283
FT /note="Transport and Golgi organization protein 2"
FT /id="PRO_0000421289"
FT VAR_SEQ 88
FT /note="V -> VAHKNILQPHNHNSNSTGINLCPKTTTSNSYRHPNPNPIQNPNTNPS
FT RGQSNNEHFLL (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_045448"
SQ SEQUENCE 283 AA; 31458 MW; 35DB64030383B2DB CRC64;
MCVIFFCADS NPQPGGYKLI LASNRDEFFA RATLSAAKWA NADHVYGGID LEPGREGGTW
LAIGHSAGFF KVGALLNLTG EPKPRDAVGR GMIVADYVTR ADEEHSILNY NERLLKDCTK
YSAFNFVSIE IGSASQPARV KLLSNVPPTL EDFQNGECYG FGNSLPHSPF EKVRHGKQEF
EAIVKAHGEA SVETLSAQLM QLLRNKHKFW PDDELKTRAP NWGEGLSSLN VHIEEHAYGS
RTHSVVLVDS ENKMHFIEET MTGLDPHGEW NKTHIEKDFQ NGV
