ID   TNG2_MOUSE              Reviewed;         276 AA.
AC   P54797;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Transport and Golgi organization 2 homolog;
DE   AltName: Full=Ser/Thr-rich protein T10 in DGCR region;
GN   Name=Tango2; Synonyms=D16H22S680E, T10;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   STRAIN=BALB/cJ;
RX   PubMed=8268909; DOI=10.1093/hmg/2.10.1577;
RA   Halford S., Wilson D.I., Daw S.C.M., Roberts C., Wadey R., Kamath S.,
RA   Wickremasinghe A., Burn J., Goodship J., Mattei M.-G., Moormon A.F.M.,
RA   Scambler P.J.;
RT   "Isolation of a gene expressed during early embryogenesis from the region
RT   of 22q11 commonly deleted in DiGeorge syndrome.";
RL   Hum. Mol. Genet. 2:1577-1582(1993).
RN   [2]
RP   SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=18775783; DOI=10.1016/j.mcn.2008.07.027;
RA   Maynard T.M., Meechan D.W., Dudevoir M.L., Gopalakrishna D., Peters A.Z.,
RA   Heindel C.C., Sugimoto T.J., Wu Y., Lieberman J.A., Lamantia A.S.;
RT   "Mitochondrial localization and function of a subset of 22q11 deletion
RT   syndrome candidate genes.";
RL   Mol. Cell. Neurosci. 39:439-451(2008).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Heart, Kidney, Liver, Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6ICL3}.
CC       Mitochondrion {ECO:0000269|PubMed:18775783}. Golgi apparatus
CC       {ECO:0000250|UniProtKB:Q6ICL3}.
CC   -!- TISSUE SPECIFICITY: Expressed in fetal liver, lung, heart and kidney
CC       (PubMed:8268909). In brain, detected in the olfactory bulb, neocortex
CC       and cerebellum (PubMed:18775783). Elevated in mitral cells and
CC       minimally expressed in bulb interneurons (PubMed:18775783). In the
CC       cortex, restricted to the upper portion of layer 5 (PubMed:18775783).
CC       In the cerebellum, excluded from Purkinje cells but expressed in
CC       granule cells (PubMed:18775783). {ECO:0000269|PubMed:18775783,
CC       ECO:0000269|PubMed:8268909}.
CC   -!- DEVELOPMENTAL STAGE: Levels increase during embryonic development, drop
CC       at postnatal day 0 and increase again during postnatal development,
CC       reaching a mmaxium at postnatal day 21 before dropping slightly at
CC       postnatal day 60 (PubMed:18775783). In 13 dpc embryos, expressed at
CC       high levels in the trachea, liver, esophagus, lung and velo-pharyngeal
CC       region (PubMed:8268909). Also detected in the central nervous system
CC       (PubMed:8268909). {ECO:0000269|PubMed:18775783,
CC       ECO:0000269|PubMed:8268909}.
CC   -!- SIMILARITY: Belongs to the Tango2 family. {ECO:0000305}.
CC   -!- CAUTION: Has been reported to be located in the Golgi apparatus (By
CC       similarity). However, another study was unable to detect Golgi
CC       localization (By similarity). Has also been reported to be located in
CC       the mitochondrion (PubMed:18775783). However, no mitochondrial
CC       localization was detected in another study which reported that the
CC       protein is primarily cytoplasmic (By similarity).
CC       {ECO:0000250|UniProtKB:Q6ICL3, ECO:0000269|PubMed:18775783}.
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DR   EMBL; X74504; CAA52612.1; -; mRNA.
DR   CCDS; CCDS28019.1; -.
DR   PIR; I48783; S37488.
DR   AlphaFoldDB; P54797; -.
DR   STRING; 10090.ENSMUSP00000111291; -.
DR   iPTMnet; P54797; -.
DR   PhosphoSitePlus; P54797; -.
DR   jPOST; P54797; -.
DR   MaxQB; P54797; -.
DR   PaxDb; P54797; -.
DR   PRIDE; P54797; -.
DR   ProteomicsDB; 259476; -.
DR   MGI; MGI:101825; Tango2.
DR   eggNOG; KOG2342; Eukaryota.
DR   InParanoid; P54797; -.
DR   ChiTaRS; Tango2; mouse.
DR   PRO; PR:P54797; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P54797; protein.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR   GO; GO:0005739; C:mitochondrion; IDA:MGI.
DR   GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR   GO; GO:0009306; P:protein secretion; IBA:GO_Central.
DR   InterPro; IPR008551; TANGO2.
DR   PANTHER; PTHR17985; PTHR17985; 1.
DR   Pfam; PF05742; TANGO2; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Golgi apparatus; Mitochondrion; Reference proteome.
FT   CHAIN           1..276
FT                   /note="Transport and Golgi organization 2 homolog"
FT                   /id="PRO_0000072396"
SQ   SEQUENCE   276 AA;  30947 MW;  7A9DE9BDFFF882E3 CRC64;
     MCIIFFKFDP RPVSKNAYRL ILAANRDEFY NRPSKLADFW GNNSEILSGL DMEEGKAGGT
     WLGISTRGKL GALTNYLQPR QEPDARGRGE LVSHFLTSDM DSLSYLKKVS TEGHLYNGFN
     IIAADLSTSK GDVVCYYGNR GEPEPIVLTP GTYGLSNALL ETPWKKLCFG KQLFMEAVEQ
     SEALPKDVLV TQLLDVLNNE EAQLPDPAIE DQGQEYVQPI LNKYAAVWCR CASYGTRTNT
     IILVDANGHV TFTERSMLDK DTSRWETNTY EFTLQS