TNG6_DROME
ID TNG6_DROME Reviewed; 921 AA.
AC Q9VJ29;
DT 06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Transport and Golgi organization protein 6;
GN Name=Tango6; ORFNames=CG18398;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=16452979; DOI=10.1038/nature04377;
RA Bard F., Casano L., Mallabiabarrena A., Wallace E., Saito K., Kitayama H.,
RA Guizzunti G., Hu Y., Wendler F., Dasgupta R., Perrimon N., Malhotra V.;
RT "Functional genomics reveals genes involved in protein secretion and Golgi
RT organization.";
RL Nature 439:604-607(2006).
CC -!- FUNCTION: May be involved in protein secretion and Golgi organization.
CC {ECO:0000269|PubMed:16452979}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16452979}. Golgi
CC apparatus {ECO:0000269|PubMed:16452979}.
CC -!- SIMILARITY: Belongs to the Tango6 family. {ECO:0000305}.
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DR EMBL; BT016081; AAV36966.1; -; mRNA.
DR EMBL; AE014134; AAF53728.1; -; Genomic_DNA.
DR RefSeq; NP_609922.2; NM_136078.4.
DR AlphaFoldDB; Q9VJ29; -.
DR SMR; Q9VJ29; -.
DR BioGRID; 61146; 18.
DR IntAct; Q9VJ29; 1.
DR STRING; 7227.FBpp0080677; -.
DR PaxDb; Q9VJ29; -.
DR PRIDE; Q9VJ29; -.
DR EnsemblMetazoa; FBtr0081133; FBpp0080677; FBgn0032728.
DR GeneID; 35155; -.
DR KEGG; dme:Dmel_CG18398; -.
DR UCSC; CG18398-RA; d. melanogaster.
DR CTD; 79613; -.
DR FlyBase; FBgn0032728; Tango6.
DR VEuPathDB; VectorBase:FBgn0032728; -.
DR eggNOG; KOG4653; Eukaryota.
DR GeneTree; ENSGT00390000010938; -.
DR HOGENOM; CLU_014339_0_0_1; -.
DR InParanoid; Q9VJ29; -.
DR OMA; DKESYTF; -.
DR OrthoDB; 917181at2759; -.
DR PhylomeDB; Q9VJ29; -.
DR SignaLink; Q9VJ29; -.
DR BioGRID-ORCS; 35155; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 35155; -.
DR PRO; PR:Q9VJ29; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0032728; Expressed in eye disc (Drosophila) and 25 other tissues.
DR ExpressionAtlas; Q9VJ29; baseline and differential.
DR Genevisible; Q9VJ29; DM.
DR GO; GO:0005829; C:cytosol; IDA:FlyBase.
DR GO; GO:0005794; C:Golgi apparatus; IDA:FlyBase.
DR GO; GO:0007030; P:Golgi organization; IMP:FlyBase.
DR GO; GO:0009306; P:protein secretion; IMP:FlyBase.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR019451; Rtp1_C1.
DR InterPro; IPR019414; Rtp1_C2.
DR InterPro; IPR039600; TANGO6/Rtp1.
DR PANTHER; PTHR20959; PTHR20959; 1.
DR Pfam; PF10363; RTP1_C1; 1.
DR Pfam; PF10304; RTP1_C2; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Golgi apparatus; Reference proteome.
FT CHAIN 1..921
FT /note="Transport and Golgi organization protein 6"
FT /id="PRO_0000421300"
SQ SEQUENCE 921 AA; 105204 MW; 5F7092191CDAB989 CRC64;
MINTAKYFAL LESLRFSKAL ANTANNSGTA EALEINLRIL EKYAKLEIGQ QLHELCLEYQ
LTDDHESSID PDSDRTICYI IRLQHVLHSI MRNINFHSDA KEDLISVAHL KLCIQASQEL
SYYSLRCQLH EDFYKSPIFC EAQGKIKANF SLMLLSIQFF INLLHIRQYH IANSMELVQR
DLLAAIVSLR VQQDSPLLDK AIAYLWQYES KADFFRNILL FKATTLCPTL AQLLHRQLLG
KLHLPQGFAS LVEALHQNPN VNSSRNAEIV ASIVARKGFS QLAQEKMVLQ VLEYCKFYLQ
NADKMCAGVL SLRRLYDLSD TNQKLIKEIL FKHWETLCNP EDIINGLILM DHQELCNRIL
LWQHLFCSST VACLPSNLLV PYLPLLLQLY DGLPMELPAS SQISAIILRC LDNREMKNEL
PAILQKLFKW EIEKEPPWKC LNPRIIILPS MNTTQIQVKV AHKDHLADHD MGRILPGLLT
SSSHHSLTCK VFLSLLGFIA KQINDKSSAS VDFISSEAEL KDFLHSKYQL KLDLLIALNQ
MVAHQPLRAQ LSQHTKELLH ILKDLLVHRS REQDTTDQIL LLVLNLLQEI LEGSENIQLS
EACKELKEQL HLLGTRSSNP LIQQSVKSLL TIIHGAWRPS EAVKIQPFQR ARSLIEEKQS
HMQVYGIQMM IDLLKKRDPA TLAQGQLIIA LALTTLKDKE SYTFLNCVRL FVSLVHVMES
DVLDKLSDEY LSETAHLDYR LVVGEAILKV AQELGPLCFR YKAVLLNCFM YGSRSPVHEF
RMSAFANLAQ LCRLLAFQVQ NFFHELLQLV NSELTTGGYV PSKRAAVLVL AELLNGMENL
LDYQEMLLPI YRLLKAIEAD ESCDPQMRQH AANGLKILNK KCTKLIQSAL EEKSLQKQIK
VLGIKDDDSP QRRNRHILEL N
