ID   TNG6_HUMAN              Reviewed;        1094 AA.
AC   Q9C0B7; Q569F9; Q9H9K1;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 2.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Transport and Golgi organization protein 6 homolog;
DE   AltName: Full=Transmembrane and coiled-coil domain-containing protein 7;
GN   Name=TANGO6; Synonyms=KIAA1746, TMCO7;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=11214970; DOI=10.1093/dnares/7.6.347;
RA   Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XIX. The
RT   complete sequences of 100 new cDNA clones from brain which code for large
RT   proteins in vitro.";
RL   DNA Res. 7:347-355(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA   Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA   Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA   Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA   Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA   Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA   Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA   Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA   Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA   Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA   Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA   Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA   Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA   Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA   Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA   Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA   Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA   DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA   Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA   Myers R.M., Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 443-1094.
RC   TISSUE=Teratocarcinoma;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Tango6 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB14224.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAB21837.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AB051533; BAB21837.1; ALT_INIT; mRNA.
DR   EMBL; AC009027; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC009082; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC009137; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK022750; BAB14224.1; ALT_INIT; mRNA.
DR   CCDS; CCDS45516.1; -.
DR   RefSeq; NP_078838.1; NM_024562.1.
DR   AlphaFoldDB; Q9C0B7; -.
DR   SMR; Q9C0B7; -.
DR   BioGRID; 122747; 97.
DR   IntAct; Q9C0B7; 6.
DR   STRING; 9606.ENSP00000261778; -.
DR   iPTMnet; Q9C0B7; -.
DR   PhosphoSitePlus; Q9C0B7; -.
DR   BioMuta; TANGO6; -.
DR   DMDM; 158706353; -.
DR   EPD; Q9C0B7; -.
DR   jPOST; Q9C0B7; -.
DR   MassIVE; Q9C0B7; -.
DR   MaxQB; Q9C0B7; -.
DR   PaxDb; Q9C0B7; -.
DR   PeptideAtlas; Q9C0B7; -.
DR   PRIDE; Q9C0B7; -.
DR   ProteomicsDB; 79993; -.
DR   Antibodypedia; 50648; 62 antibodies from 14 providers.
DR   DNASU; 79613; -.
DR   Ensembl; ENST00000261778.2; ENSP00000261778.1; ENSG00000103047.8.
DR   GeneID; 79613; -.
DR   KEGG; hsa:79613; -.
DR   MANE-Select; ENST00000261778.2; ENSP00000261778.1; NM_024562.2; NP_078838.1.
DR   UCSC; uc002ewi.5; human.
DR   CTD; 79613; -.
DR   DisGeNET; 79613; -.
DR   GeneCards; TANGO6; -.
DR   HGNC; HGNC:25749; TANGO6.
DR   HPA; ENSG00000103047; Low tissue specificity.
DR   neXtProt; NX_Q9C0B7; -.
DR   OpenTargets; ENSG00000103047; -.
DR   PharmGKB; PA162405811; -.
DR   VEuPathDB; HostDB:ENSG00000103047; -.
DR   eggNOG; KOG4653; Eukaryota.
DR   GeneTree; ENSGT00390000010938; -.
DR   HOGENOM; CLU_006971_1_0_1; -.
DR   InParanoid; Q9C0B7; -.
DR   OMA; TLVFTRH; -.
DR   OrthoDB; 917181at2759; -.
DR   PhylomeDB; Q9C0B7; -.
DR   TreeFam; TF330876; -.
DR   PathwayCommons; Q9C0B7; -.
DR   SignaLink; Q9C0B7; -.
DR   BioGRID-ORCS; 79613; 748 hits in 1078 CRISPR screens.
DR   ChiTaRS; TANGO6; human.
DR   GenomeRNAi; 79613; -.
DR   Pharos; Q9C0B7; Tdark.
DR   PRO; PR:Q9C0B7; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   RNAct; Q9C0B7; protein.
DR   Bgee; ENSG00000103047; Expressed in bone marrow cell and 110 other tissues.
DR   ExpressionAtlas; Q9C0B7; baseline and differential.
DR   Genevisible; Q9C0B7; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009306; P:protein secretion; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR019451; Rtp1_C1.
DR   InterPro; IPR019414; Rtp1_C2.
DR   InterPro; IPR039600; TANGO6/Rtp1.
DR   PANTHER; PTHR20959; PTHR20959; 1.
DR   Pfam; PF10363; RTP1_C1; 1.
DR   Pfam; PF10304; RTP1_C2; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   1: Evidence at protein level;
KW   Membrane; Phosphoprotein; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..1094
FT                   /note="Transport and Golgi organization protein 6 homolog"
FT                   /id="PRO_0000305059"
FT   TRANSMEM        468..488
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REPEAT          873..909
FT                   /note="HEAT 1"
FT   REPEAT          952..988
FT                   /note="HEAT 2"
FT   REGION          777..834
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        777..796
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        797..834
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         556
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8C3S2"
SQ   SEQUENCE   1094 AA;  120748 MW;  48E9BBD05E6902CE CRC64;
     MAARQAVGSG AQETCGLDRI LEALKLLLSP GGSGSSSLQV TKHDVLLATL KSNLSALEDK
     FLKDPQWKNL KLLRDEIADK AEWPQNSVDV TWSFTSQTLL LLLCLKETMI RLAANFNPGK
     PNPRTPEVAP ALSPDALSIS QQKTVQFVLQ FVVTLGICPY LMPGVGVPLR YRTEFGAVVQ
     DVVCFDAAPD ATRRLYTSCK ALLNVAQHTS LGSLIFCHHF GDIAAGLCQL GFCPTKRKLL
     TPAEEVLTEE ERTLSRGALR DMLDQVYQPL AVRELLILQG GPPQSCTDVK TQMRCRAPAW
     LRRLCGQLLS ERLMRPNGVQ AVVRGILEGA GAGAAGGSDA EVTAADWKKC DLIAKILASC
     PQQSLSPENY YRDICPQVLD LFHFQDKLTA RQFQRVATTT FITLSRERPH LAAKYLLQPV
     LAPLHRCLNT AELSESDMVP GTILVTEEEL SRCIEDVFKV YVVGNEPLTV LMDSLLPVLG
     VLFLLYCFTK QSVSHIRSLC QEILLWILGK LERKKAIASL KGFAGLDKAV PSLHSLCQFR
     VATQGGIMIT IKEAISDEDE DEALYQKVSS EQGRVEHLGD LLSHCQECGL AGDFFIFCLK
     ELTHVASENE TELKTEPFSS KSLLELEQHQ TLLVEGQERK LLVLQLMAVL CERMSEQIFT
     NVTQVVDFVA ATLQRACASL AHQAESTVES QTLSMSMGLV AVMLGGAVQL KSSDFAVLKQ
     LLPLLEKVSN TYPDPVIQEL AVDLRITIST HGAFATEAVS MAAQSTLNRK DLEGKIEEQQ
     QTSHERPTDV AHSHLEQQQS HETAPQTGLQ SNAPIIPQGV NEPSTTTSQK SGSVTTEQLQ
     EVLLSAYDPQ IPTRAAALRT LSHWIEQREA KALEMQEKLL KIFLENLEHE DTFVYLSAIQ
     GVALLSDVYP EKILPDLLAQ YDSSKDKHTP ETRMKVGEVL MRIVRALGDM VSKYREPLIH
     TFLRGVRDPD GAHRASSLAN LGELCQRLDF LLGSVVHEVT ACLIAVAKTD GEVQVRRAAI
     HVVVLLLRGL SQKATEVLSA VLKDLYHLLK HVVCLEPDDV AKLHAQLALE ELDDIMKNFL
     FPPQKLEKKI MVLP