TNG6_MOUSE
ID TNG6_MOUSE Reviewed; 1079 AA.
AC Q8C3S2; Q69ZB6; Q6NXV4; Q8C6M0; Q8C8G2;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Transport and Golgi organization protein 6 homolog;
DE AltName: Full=Transmembrane and coiled-coil domain-containing protein 7;
GN Name=Tango6; Synonyms=Kiaa1746, Tmco7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Lung, and Ovary;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Embryonic germ cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-1079 (ISOFORM 3).
RC TISSUE=Pancreatic islet;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-561, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Liver, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8C3S2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8C3S2-2; Sequence=VSP_028207, VSP_028208;
CC Name=3;
CC IsoId=Q8C3S2-3; Sequence=VSP_028206;
CC -!- SIMILARITY: Belongs to the Tango6 family. {ECO:0000305}.
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DR EMBL; AK047206; BAC32990.1; -; mRNA.
DR EMBL; AK054283; BAC35717.1; -; mRNA.
DR EMBL; AK085030; BAC39344.1; -; mRNA.
DR EMBL; BC066869; AAH66869.1; -; mRNA.
DR EMBL; BC069838; AAH69838.1; -; mRNA.
DR EMBL; AK173250; BAD32528.1; -; mRNA.
DR CCDS; CCDS22639.1; -. [Q8C3S2-1]
DR RefSeq; NP_766625.1; NM_173037.1. [Q8C3S2-1]
DR AlphaFoldDB; Q8C3S2; -.
DR SMR; Q8C3S2; -.
DR BioGRID; 234875; 1.
DR STRING; 10090.ENSMUSP00000043953; -.
DR iPTMnet; Q8C3S2; -.
DR PhosphoSitePlus; Q8C3S2; -.
DR EPD; Q8C3S2; -.
DR MaxQB; Q8C3S2; -.
DR PaxDb; Q8C3S2; -.
DR PeptideAtlas; Q8C3S2; -.
DR PRIDE; Q8C3S2; -.
DR ProteomicsDB; 259274; -. [Q8C3S2-1]
DR ProteomicsDB; 259275; -. [Q8C3S2-2]
DR ProteomicsDB; 259276; -. [Q8C3S2-3]
DR Antibodypedia; 50648; 62 antibodies from 14 providers.
DR DNASU; 272538; -.
DR Ensembl; ENSMUST00000048359; ENSMUSP00000043953; ENSMUSG00000041949. [Q8C3S2-1]
DR GeneID; 272538; -.
DR KEGG; mmu:272538; -.
DR UCSC; uc009ngk.1; mouse. [Q8C3S2-2]
DR UCSC; uc009ngl.1; mouse. [Q8C3S2-1]
DR UCSC; uc012gjv.1; mouse. [Q8C3S2-3]
DR CTD; 79613; -.
DR MGI; MGI:2142786; Tango6.
DR VEuPathDB; HostDB:ENSMUSG00000041949; -.
DR eggNOG; KOG4653; Eukaryota.
DR GeneTree; ENSGT00390000010938; -.
DR HOGENOM; CLU_006971_1_0_1; -.
DR InParanoid; Q8C3S2; -.
DR OMA; TLVFTRH; -.
DR OrthoDB; 917181at2759; -.
DR PhylomeDB; Q8C3S2; -.
DR TreeFam; TF330876; -.
DR BioGRID-ORCS; 272538; 22 hits in 73 CRISPR screens.
DR ChiTaRS; Tango6; mouse.
DR PRO; PR:Q8C3S2; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8C3S2; protein.
DR Bgee; ENSMUSG00000041949; Expressed in ear vesicle and 148 other tissues.
DR ExpressionAtlas; Q8C3S2; baseline and differential.
DR Genevisible; Q8C3S2; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009306; P:protein secretion; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR019451; Rtp1_C1.
DR InterPro; IPR019414; Rtp1_C2.
DR InterPro; IPR039600; TANGO6/Rtp1.
DR PANTHER; PTHR20959; PTHR20959; 1.
DR Pfam; PF10363; RTP1_C1; 1.
DR Pfam; PF10304; RTP1_C2; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Phosphoprotein; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..1079
FT /note="Transport and Golgi organization protein 6 homolog"
FT /id="PRO_0000305060"
FT TRANSMEM 473..493
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 864..902
FT /note="HEAT 1"
FT REPEAT 937..973
FT /note="HEAT 2"
FT REGION 767..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 783..818
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 561
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 886..891
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15368895"
FT /id="VSP_028206"
FT VAR_SEQ 887..915
FT /note="IALLSDVYPEEILVDLLAKYDSGKDKHTP -> KLTWTKMISCSLRGTATRH
FT NWLFVHLSAP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028207"
FT VAR_SEQ 916..1079
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028208"
FT CONFLICT 568
FT /note="L -> P (in Ref. 2; AAH66869/AAH69838)"
FT /evidence="ECO:0000305"
FT CONFLICT 1067
FT /note="P -> L (in Ref. 2; AAH66869/AAH69838)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1079 AA; 118732 MW; B3C3B425C7DCB3DC CRC64;
MAASGPAAAA PSGVLVTCGL EQVLEALKLL LSPGGSGSSS LQNTKHDVLL QTLKSNLSAL
EAKFLKDAQW KKLKALRDEL ADKAEWPQSS EDITWSFTSQ TLLLLLCLKE VLARLVADFN
PGKPNPRTPE AAPALSPDTL SVSQQKTFQS VLQFVVTLGV CPYLIPGVGV PLRDRTEFGA
VVQDVVRLEA APHATRRLYI CCRVLLDLAQ HASLGSLIFC RHFGDIAAGL CQLGFCPTKR
KPPGPVEEVL TEEERTLSRR ALRDILDQVY QPLAVRELLT LQGGPRQPCT DVKTQLRCRA
QAPAWLRRLC GQLLSERLMR PNGVQAVVRG ILEGAGAGAA GGSDAEATAA DWRKCDLIAK
ILASCPQQSL SPESYYKDIC PQILDLFHLQ DKLTARQFQR VATTTFITLS RERPELAAKY
LLQPMLAPLQ RCLSTAEIPE SDMVPGAILV TEEELSRCVE DVFKVYVVAN EPVPVLLDSL
LPLLRVFFSL YCFTQQSVSH IRSLCQEILL WILVKLERKK AIASLKGFSG LDKTVPTLHP
QCQFRAATHG GIVITAKEAI SDDEDEALYQ KVSSEQSQVE HLGDLLLHCQ QCGLAGDFFI
FCLKELSHLL EDREAEFTPK PSCYASLLEL EHHQTLLIED QERKLQVLQL LAVLCEKMSE
QIFTHVTQVV DFVAATLQRA CAGLAHEAES AVGSQTLSMS MGLVAVMLGG AVQLKSSDFA
VLKQLLPLLE RVSNTYPDPV IQELAADLRI TISTHGAFST DAVSTAAQST LNQKDPGQKI
EEQRQTSPDI STEGAQKPPR TGQGSSGPCT ATSQPPGSIT TQQFREVLLS ACDPEVPTRA
AALRTLARWV EQREARALEE QKKLLQIFLE NLEHEDSFVY LSAIQGIALL SDVYPEEILV
DLLAKYDSGK DKHTPETRMK VGEVLMRVVR ALGDMVSKYR EPLIHTFLRG VRDPDAAHRA
SSLANLGELC QCLHFLLGPV VHEVTACLIA VAKTDNDVQV RRAAVHVVVL LLRGLSQKAT
EVLSDVLRDL YHLLKHVVRL EPDDVAKLHA QLALEELDEI MRNFLFPPQK LEKKIVVLP
