ID   TNNI1_RABIT             Reviewed;         184 AA.
AC   P02645;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Troponin I, slow skeletal muscle;
DE   AltName: Full=Troponin I, slow-twitch isoform;
GN   Name=TNNI1;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   PROTEIN SEQUENCE, AND ACETYLATION AT PRO-1.
RX   PubMed=588250; DOI=10.1042/bj1670183;
RA   Grand R.J.A., Wilkinson J.M.;
RT   "The amino acid sequence of rabbit slow-muscle troponin I.";
RL   Biochem. J. 167:183-192(1977).
CC   -!- FUNCTION: Troponin I is the inhibitory subunit of troponin, the thin
CC       filament regulatory complex which confers calcium-sensitivity to
CC       striated muscle actomyosin ATPase activity.
CC   -!- SUBUNIT: Binds to actin and tropomyosin.
CC   -!- PTM: In the muscle sample, approximately 25% of the chains were
CC       blocked. Pro-1 is probably acetylated.
CC   -!- PTM: The N-terminus is blocked.
CC   -!- SIMILARITY: Belongs to the troponin I family. {ECO:0000305}.
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DR   PIR; A03089; TPRBIW.
DR   AlphaFoldDB; P02645; -.
DR   SMR; P02645; -.
DR   STRING; 9986.ENSOCUP00000008977; -.
DR   iPTMnet; P02645; -.
DR   eggNOG; KOG3977; Eukaryota.
DR   InParanoid; P02645; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005861; C:troponin complex; IEA:InterPro.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.350; -; 1.
DR   InterPro; IPR001978; Troponin.
DR   InterPro; IPR038077; Troponin_sf.
DR   Pfam; PF00992; Troponin; 1.
DR   SUPFAM; SSF90250; SSF90250; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Actin-binding; Direct protein sequencing; Muscle protein;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..184
FT                   /note="Troponin I, slow skeletal muscle"
FT                   /id="PRO_0000186141"
FT   REGION          1..45
FT                   /note="Involved in binding TNC"
FT   REGION          94..115
FT                   /note="Involved in binding TNC and actin"
FT   MOD_RES         1
FT                   /note="N-acetylproline; partial"
FT                   /evidence="ECO:0000269|PubMed:588250"
FT   MOD_RES         55
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9WUZ5"
FT   VARIANT         183..184
FT                   /note="Missing (in some molecules)"
SQ   SEQUENCE   184 AA;  21144 MW;  4CC73E38AC6FD3E9 CRC64;
     PEVERKSKIT ASRKLLKSLM LAKAKECQQE HEAREAEKVR YLAERIPALQ TRGLSLSALQ
     DLCRQLHAKV EVVDEERYDI EAKCLHNTRE IKDLKLKVLD LRGKFKRPPL RRVRVSADAM
     LRALLGSKHK VSMDLRANLK SVKKEDTEKE RPVEVGDWRK NVEAMSGMEG RKKMFDAAKS
     PTSQ