ID   BTG1_BOVIN              Reviewed;         171 AA.
AC   P53348; A5D7R5; O18950; Q3SZM4;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 2.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Protein BTG1;
DE   AltName: Full=B-cell translocation gene 1 protein;
DE   AltName: Full=Myocardial vascular inhibition factor;
DE            Short=VIF;
GN   Name=BTG1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Heart;
RA   Zimmermann R., Westernacher-Keil D., Vosschuulte R., Freude B., Schaper J.,
RA   Winkler B., Schaper W.;
RT   "Cloning and cDNA sequence determination of an antiproliferative protein
RT   (vascular inhibition factor; VIF) from bovine heart and expression in a
RT   porcine model of coronary microembolization.";
RL   Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus, and Hereford;
RC   TISSUE=Fetal skin, Ileum, and Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 44-141.
RA   Clark T.G., Morris J., Akamatsu M., McGraw R.A., Ivarie R.;
RT   "Cloning and sequence analysis of a bovine BTG1 cDNA.";
RL   Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Anti-proliferative protein.
CC   -!- SUBUNIT: Interacts with CNOT7 and CNOT8. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BTG family. {ECO:0000305}.
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DR   EMBL; AF014008; AAB64305.1; -; mRNA.
DR   EMBL; BC102787; AAI02788.1; -; mRNA.
DR   EMBL; BC140655; AAI40656.1; -; mRNA.
DR   EMBL; BC142147; AAI42148.1; -; mRNA.
DR   EMBL; U19802; AAA61824.1; -; mRNA.
DR   RefSeq; NP_776424.1; NM_173999.3.
DR   AlphaFoldDB; P53348; -.
DR   SMR; P53348; -.
DR   STRING; 9913.ENSBTAP00000027091; -.
DR   PaxDb; P53348; -.
DR   PRIDE; P53348; -.
DR   GeneID; 281032; -.
DR   KEGG; bta:281032; -.
DR   CTD; 694; -.
DR   eggNOG; KOG4006; Eukaryota.
DR   HOGENOM; CLU_079660_4_0_1; -.
DR   InParanoid; P53348; -.
DR   OrthoDB; 1439942at2759; -.
DR   TreeFam; TF105272; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0019899; F:enzyme binding; ISS:UniProtKB.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; ISS:UniProtKB.
DR   GO; GO:0045930; P:negative regulation of mitotic cell cycle; IBA:GO_Central.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.
DR   GO; GO:0045603; P:positive regulation of endothelial cell differentiation; ISS:UniProtKB.
DR   GO; GO:2000271; P:positive regulation of fibroblast apoptotic process; ISS:UniProtKB.
DR   Gene3D; 3.90.640.90; -; 1.
DR   InterPro; IPR002087; Anti_prolifrtn.
DR   InterPro; IPR033332; BTG.
DR   InterPro; IPR036054; BTG-like_sf.
DR   InterPro; IPR033330; BTG1.
DR   PANTHER; PTHR22978; PTHR22978; 1.
DR   PANTHER; PTHR22978:SF30; PTHR22978:SF30; 1.
DR   Pfam; PF07742; BTG; 1.
DR   PRINTS; PR00310; ANTIPRLFBTG1.
DR   SMART; SM00099; btg1; 1.
DR   SUPFAM; SSF160696; SSF160696; 1.
DR   PROSITE; PS00960; BTG_1; 1.
DR   PROSITE; PS01203; BTG_2; 1.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..171
FT                   /note="Protein BTG1"
FT                   /id="PRO_0000143799"
FT   MOD_RES         159
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P62324"
SQ   SEQUENCE   171 AA;  19195 MW;  D766E0E626CA32FA CRC64;
     MHPFYSRAAT MIGEIAAAVS FISKFLRTKG LTSERQLQTF SQSLQELLAE HYKHHWFPEK
     PCKGSGYRCI RINHKMDPLI GQAAQRIGLS SQELFRLLPS ELTLWVDPYE VSYRIGEDGS
     ICVLYEASPA GGSTQNSTNV QMVDSRISCK EELLLGRTSP SKNYNMMTVS G