BTG1_HUMAN
ID BTG1_HUMAN Reviewed; 171 AA.
AC P62324; P31607;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Protein BTG1;
DE AltName: Full=B-cell translocation gene 1 protein;
GN Name=BTG1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RC TISSUE=Lymphoblastoma;
RX PubMed=1373383; DOI=10.1002/j.1460-2075.1992.tb05213.x;
RA Rouault J.-P., Rimokh R., Tessa C., Paranhos G., Ffrench M., Duret L.,
RA Garoccio M., Germain D., Samarut J., Magaud J.-P.;
RT "BTG1, a member of a new family of antiproliferative genes.";
RL EMBO J. 11:1663-1670(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS SER-139 AND GLU-141.
RG NIEHS SNPs program;
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP INTERACTION WITH CNOT7.
RX PubMed=9712883; DOI=10.1074/jbc.273.35.22563;
RA Rouault J.P., Prevot D., Berthet C., Birot A.M., Billaud M., Magaud J.P.,
RA Corbo L.;
RT "Interaction of BTG1 and p53-regulated BTG2 gene products with mCaf1, the
RT murine homolog of a component of the yeast CCR4 transcriptional regulatory
RT complex.";
RL J. Biol. Chem. 273:22563-22569(1998).
RN [6]
RP INTERACTION WITH CNOT8.
RX PubMed=11136725; DOI=10.1074/jbc.m008201200;
RA Prevot D., Morel A.P., Voeltzel T., Rostan M.C., Rimokh R., Magaud J.P.,
RA Corbo L.;
RT "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1,
RT the human homolog of a component of the yeast CCR4 transcriptional complex:
RT involvement in estrogen receptor alpha signaling pathway.";
RL J. Biol. Chem. 276:9640-9648(2001).
RN [7]
RP CHROMOSOMAL TRANSLOCATION WITH MYC.
RX PubMed=2069907; DOI=10.1002/gcc.2870030106;
RA Rimokh R., Rouault J.P., Wahbi K., Gadoux M., Lafage M., Archimbaud E.,
RA Charrin C., Gentilhomme O., Germain D., Samarut J.;
RT "A chromosome 12 coding region is juxtaposed to the MYC protooncogene locus
RT in a t(8;12)(q24;q22) translocation in a case of B-cell chronic lymphocytic
RT leukemia.";
RL Genes Chromosomes Cancer 3:24-36(1991).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-159, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: Anti-proliferative protein. {ECO:0000269|PubMed:1373383}.
CC -!- SUBUNIT: Interacts with CNOT7 and CNOT8. {ECO:0000269|PubMed:11136725,
CC ECO:0000269|PubMed:9712883}.
CC -!- INTERACTION:
CC P62324; Q9UIV1: CNOT7; NbExp=4; IntAct=EBI-742279, EBI-2105113;
CC P62324; Q9UFF9: CNOT8; NbExp=6; IntAct=EBI-742279, EBI-742299;
CC P62324; Q13158: FADD; NbExp=5; IntAct=EBI-742279, EBI-494804;
CC P62324; P62993: GRB2; NbExp=3; IntAct=EBI-742279, EBI-401755;
CC P62324; O43639: NCK2; NbExp=3; IntAct=EBI-742279, EBI-713635;
CC P62324; Q60809: Cnot7; Xeno; NbExp=5; IntAct=EBI-742279, EBI-2104739;
CC -!- DEVELOPMENTAL STAGE: Its expression is associated with the early G1
CC phase of the cell cycle. {ECO:0000269|PubMed:1373383}.
CC -!- DISEASE: Note=A chromosomal aberration involving BTG1 may be a cause of
CC a form of B-cell chronic lymphocytic leukemia. Translocation
CC t(8;12)(q24;q22) with MYC. {ECO:0000269|PubMed:2069907}.
CC -!- SIMILARITY: Belongs to the BTG family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC URL="http://egp.gs.washington.edu/data/btg1/";
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DR EMBL; X61123; CAA43435.1; -; mRNA.
DR EMBL; BT019840; AAV38643.1; -; mRNA.
DR EMBL; AY850133; AAV97814.1; -; Genomic_DNA.
DR EMBL; BC016759; AAH16759.1; -; mRNA.
DR EMBL; BC064953; AAH64953.1; -; mRNA.
DR CCDS; CCDS9043.1; -.
DR PIR; S20947; S20947.
DR RefSeq; NP_001722.1; NM_001731.2.
DR AlphaFoldDB; P62324; -.
DR SMR; P62324; -.
DR BioGRID; 107159; 22.
DR IntAct; P62324; 10.
DR MINT; P62324; -.
DR STRING; 9606.ENSP00000256015; -.
DR iPTMnet; P62324; -.
DR PhosphoSitePlus; P62324; -.
DR BioMuta; BTG1; -.
DR DMDM; 59799172; -.
DR EPD; P62324; -.
DR MassIVE; P62324; -.
DR PaxDb; P62324; -.
DR PeptideAtlas; P62324; -.
DR PRIDE; P62324; -.
DR ProteomicsDB; 57394; -.
DR Antibodypedia; 1186; 231 antibodies from 29 providers.
DR DNASU; 694; -.
DR Ensembl; ENST00000256015.5; ENSP00000256015.3; ENSG00000133639.6.
DR GeneID; 694; -.
DR KEGG; hsa:694; -.
DR MANE-Select; ENST00000256015.5; ENSP00000256015.3; NM_001731.3; NP_001722.1.
DR CTD; 694; -.
DR DisGeNET; 694; -.
DR GeneCards; BTG1; -.
DR HGNC; HGNC:1130; BTG1.
DR HPA; ENSG00000133639; Low tissue specificity.
DR MIM; 109580; gene.
DR neXtProt; NX_P62324; -.
DR OpenTargets; ENSG00000133639; -.
DR PharmGKB; PA25450; -.
DR VEuPathDB; HostDB:ENSG00000133639; -.
DR eggNOG; KOG4006; Eukaryota.
DR GeneTree; ENSGT00950000182952; -.
DR HOGENOM; CLU_079660_4_0_1; -.
DR InParanoid; P62324; -.
DR OMA; YNNMMTV; -.
DR OrthoDB; 1439942at2759; -.
DR PhylomeDB; P62324; -.
DR TreeFam; TF105272; -.
DR PathwayCommons; P62324; -.
DR Reactome; R-HSA-9617828; FOXO-mediated transcription of cell cycle genes.
DR SignaLink; P62324; -.
DR SIGNOR; P62324; -.
DR BioGRID-ORCS; 694; 20 hits in 1079 CRISPR screens.
DR ChiTaRS; BTG1; human.
DR GeneWiki; BTG1; -.
DR GenomeRNAi; 694; -.
DR Pharos; P62324; Tbio.
DR PRO; PR:P62324; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; P62324; protein.
DR Bgee; ENSG00000133639; Expressed in lower lobe of lung and 217 other tissues.
DR ExpressionAtlas; P62324; baseline and differential.
DR Genevisible; P62324; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0019899; F:enzyme binding; IPI:UniProtKB.
DR GO; GO:0019900; F:kinase binding; NAS:UniProtKB.
DR GO; GO:0003712; F:transcription coregulator activity; NAS:UniProtKB.
DR GO; GO:0016477; P:cell migration; NAS:UniProtKB.
DR GO; GO:0030308; P:negative regulation of cell growth; NAS:UniProtKB.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IDA:UniProtKB.
DR GO; GO:0045930; P:negative regulation of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IMP:UniProtKB.
DR GO; GO:0045603; P:positive regulation of endothelial cell differentiation; IMP:UniProtKB.
DR GO; GO:2000271; P:positive regulation of fibroblast apoptotic process; IMP:UniProtKB.
DR GO; GO:0045663; P:positive regulation of myoblast differentiation; IDA:MGI.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR Gene3D; 3.90.640.90; -; 1.
DR InterPro; IPR002087; Anti_prolifrtn.
DR InterPro; IPR033332; BTG.
DR InterPro; IPR036054; BTG-like_sf.
DR InterPro; IPR033330; BTG1.
DR PANTHER; PTHR22978; PTHR22978; 1.
DR PANTHER; PTHR22978:SF30; PTHR22978:SF30; 1.
DR Pfam; PF07742; BTG; 1.
DR PRINTS; PR00310; ANTIPRLFBTG1.
DR SMART; SM00099; btg1; 1.
DR SUPFAM; SSF160696; SSF160696; 1.
DR PROSITE; PS00960; BTG_1; 1.
DR PROSITE; PS01203; BTG_2; 1.
PE 1: Evidence at protein level;
KW Chromosomal rearrangement; Phosphoprotein; Proto-oncogene;
KW Reference proteome.
FT CHAIN 1..171
FT /note="Protein BTG1"
FT /id="PRO_0000143800"
FT MOD_RES 159
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VARIANT 139
FT /note="N -> S (in dbSNP:rs28399541)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_021345"
FT VARIANT 141
FT /note="Q -> E (in dbSNP:rs28399542)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_021346"
SQ SEQUENCE 171 AA; 19209 MW; EFED8BE09013BE60 CRC64;
MHPFYTRAAT MIGEIAAAVS FISKFLRTKG LTSERQLQTF SQSLQELLAE HYKHHWFPEK
PCKGSGYRCI RINHKMDPLI GQAAQRIGLS SQELFRLLPS ELTLWVDPYE VSYRIGEDGS
ICVLYEASPA GGSTQNSTNV QMVDSRISCK EELLLGRTSP SKNYNMMTVS G
