BTG1_MOUSE
ID BTG1_MOUSE Reviewed; 171 AA.
AC P62325; P31607;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Protein BTG1;
DE AltName: Full=B-cell translocation gene 1 protein;
GN Name=Btg1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8325512; DOI=10.1016/0378-1119(93)90284-a;
RA Rouault J.-P., Samarut C., Duret L., Tessa C., Samarut J., Magaud J.-P.;
RT "Sequence analysis reveals that the BTG1 anti-proliferative gene is
RT conserved throughout evolution in its coding and 3' non-coding regions.";
RL Gene 129:303-306(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RA Suk K., Erickson K.L.;
RL Submitted (MAY-1993) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Anti-proliferative protein. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CNOT7 and CNOT8. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the BTG family. {ECO:0000305}.
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DR EMBL; Z16410; CAA78902.1; -; Genomic_DNA.
DR EMBL; L16846; AAA37327.1; -; mRNA.
DR EMBL; BC006834; AAH06834.1; -; mRNA.
DR EMBL; BC018309; AAH18309.1; -; mRNA.
DR CCDS; CCDS24140.1; -.
DR PIR; I48272; I48272.
DR RefSeq; NP_031595.1; NM_007569.2.
DR AlphaFoldDB; P62325; -.
DR SMR; P62325; -.
DR BioGRID; 198397; 2.
DR IntAct; P62325; 2.
DR STRING; 10090.ENSMUSP00000038863; -.
DR iPTMnet; P62325; -.
DR PhosphoSitePlus; P62325; -.
DR jPOST; P62325; -.
DR PaxDb; P62325; -.
DR PRIDE; P62325; -.
DR ProteomicsDB; 265385; -.
DR DNASU; 12226; -.
DR Ensembl; ENSMUST00000038377; ENSMUSP00000038863; ENSMUSG00000036478.
DR GeneID; 12226; -.
DR KEGG; mmu:12226; -.
DR UCSC; uc007gww.2; mouse.
DR CTD; 694; -.
DR MGI; MGI:88215; Btg1.
DR VEuPathDB; HostDB:ENSMUSG00000036478; -.
DR eggNOG; KOG4006; Eukaryota.
DR GeneTree; ENSGT00950000182952; -.
DR HOGENOM; CLU_079660_4_0_1; -.
DR InParanoid; P62325; -.
DR OMA; YNNMMTV; -.
DR OrthoDB; 1439942at2759; -.
DR PhylomeDB; P62325; -.
DR TreeFam; TF105272; -.
DR BioGRID-ORCS; 12226; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Btg1; mouse.
DR PRO; PR:P62325; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; P62325; protein.
DR Bgee; ENSMUSG00000036478; Expressed in granulocyte and 170 other tissues.
DR ExpressionAtlas; P62325; baseline and differential.
DR Genevisible; P62325; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0019899; F:enzyme binding; ISS:UniProtKB.
DR GO; GO:0008283; P:cell population proliferation; IDA:MGI.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IDA:MGI.
DR GO; GO:0045930; P:negative regulation of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.
DR GO; GO:0043085; P:positive regulation of catalytic activity; NAS:UniProtKB.
DR GO; GO:0045603; P:positive regulation of endothelial cell differentiation; ISS:UniProtKB.
DR GO; GO:2000271; P:positive regulation of fibroblast apoptotic process; ISS:UniProtKB.
DR GO; GO:0045663; P:positive regulation of myoblast differentiation; ISO:MGI.
DR GO; GO:0006479; P:protein methylation; IDA:MGI.
DR GO; GO:0006979; P:response to oxidative stress; IEA:Ensembl.
DR GO; GO:0043434; P:response to peptide hormone; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR Gene3D; 3.90.640.90; -; 1.
DR InterPro; IPR002087; Anti_prolifrtn.
DR InterPro; IPR033332; BTG.
DR InterPro; IPR036054; BTG-like_sf.
DR InterPro; IPR033330; BTG1.
DR PANTHER; PTHR22978; PTHR22978; 1.
DR PANTHER; PTHR22978:SF30; PTHR22978:SF30; 1.
DR Pfam; PF07742; BTG; 1.
DR PRINTS; PR00310; ANTIPRLFBTG1.
DR SMART; SM00099; btg1; 1.
DR SUPFAM; SSF160696; SSF160696; 1.
DR PROSITE; PS00960; BTG_1; 1.
DR PROSITE; PS01203; BTG_2; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Proto-oncogene; Reference proteome.
FT CHAIN 1..171
FT /note="Protein BTG1"
FT /id="PRO_0000143801"
FT MOD_RES 159
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P62324"
SQ SEQUENCE 171 AA; 19209 MW; EFED8BE09013BE60 CRC64;
MHPFYTRAAT MIGEIAAAVS FISKFLRTKG LTSERQLQTF SQSLQELLAE HYKHHWFPEK
PCKGSGYRCI RINHKMDPLI GQAAQRIGLS SQELFRLLPS ELTLWVDPYE VSYRIGEDGS
ICVLYEASPA GGSTQNSTNV QMVDSRISCK EELLLGRTSP SKNYNMMTVS G
