TNPO_DICDI
ID TNPO_DICDI Reviewed; 931 AA.
AC Q55CQ7;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Transportin;
DE AltName: Full=Importin subunit beta;
DE AltName: Full=Karyopherin subunit beta;
GN Name=tnpo; ORFNames=DDB_G0269948;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Functions in nuclear protein import via a substrate-importin
CC alpha-beta transport complex that passes though the nuclear pore
CC complexes (NPC). Mediates docking of the substrate-importin complex to
CC distinct nucleoporins (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Forms a complex with an importin alpha subunit. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus envelope
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the importin beta family. Importin beta-2
CC subfamily. {ECO:0000305}.
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DR EMBL; AAFI02000005; EAL72324.1; -; Genomic_DNA.
DR RefSeq; XP_646424.1; XM_641332.2.
DR AlphaFoldDB; Q55CQ7; -.
DR SMR; Q55CQ7; -.
DR STRING; 44689.DDB0234262; -.
DR PaxDb; Q55CQ7; -.
DR EnsemblProtists; EAL72324; EAL72324; DDB_G0269948.
DR GeneID; 8617382; -.
DR KEGG; ddi:DDB_G0269948; -.
DR dictyBase; DDB_G0269948; tnpo.
DR eggNOG; KOG2023; Eukaryota.
DR HOGENOM; CLU_008136_1_0_1; -.
DR InParanoid; Q55CQ7; -.
DR OMA; MFPLLEC; -.
DR PhylomeDB; Q55CQ7; -.
DR Reactome; R-DDI-450513; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA.
DR PRO; PR:Q55CQ7; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005829; C:cytosol; ISS:dictyBase.
DR GO; GO:0005635; C:nuclear envelope; ISS:dictyBase.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central.
DR GO; GO:0008139; F:nuclear localization sequence binding; ISS:dictyBase.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; ISS:dictyBase.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040122; Importin_beta.
DR PANTHER; PTHR10527; PTHR10527; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Protein transport; Reference proteome; Repeat;
KW Transport.
FT CHAIN 1..931
FT /note="Transportin"
FT /id="PRO_0000327493"
FT REPEAT 10..37
FT /note="HEAT 1"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT DOMAIN 32..99
FT /note="Importin N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00115"
FT REPEAT 42..79
FT /note="HEAT 2"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 88..121
FT /note="HEAT 3"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 127..164
FT /note="HEAT 4"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 171..201
FT /note="HEAT 5"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 214..241
FT /note="HEAT 6"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 253..280
FT /note="HEAT 7"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 296..421
FT /note="HEAT 8"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 430..459
FT /note="HEAT 9"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 471..498
FT /note="HEAT 10"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 512..545
FT /note="HEAT 11"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 553..586
FT /note="HEAT 12"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 594..632
FT /note="HEAT 13"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 640..693
FT /note="HEAT 14"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 704..735
FT /note="HEAT 15"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 743..776
FT /note="HEAT 16"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 784..819
FT /note="HEAT 17"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 827..860
FT /note="HEAT 18"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 869..900
FT /note="HEAT 19"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REGION 317..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..401
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 931 AA; 104796 MW; 50BAECAB54E515D8 CRC64;
MSEWVPNQDG LKQLVYVLNL SNSTSREVHD QIREELDKFH SVPDYNNYLT LIFKSNELQP
HIRSVAGLVL KTNIKQYFEK MPREVQNYIK REILPVLSDP DASVRHTVGN IITNLIKKSC
FSEWPELLPA LNLALDSNSQ DLIEGSLYTL SLLCEDSTKK LDSDDSGRAL NQLIPKLIMF
FKCNNADFRK KALVSISYFI ISMPGALLIN MEAFLKGIFS MSEDPSEAVR TNVCKTLVTL
VETKIEFLLP YIKDVIQYML HATKDKSEEV ALEACEFWTA ISQAEGCRDL LRDYLPVLVP
ILLNGMVYTE QDYEYLDQGD DSMTPDRPQD IKPFIASTKS HGSGSSGGGQ DTGFVNPDNN
NNSNNNNSSN NNSSNNNNNN NNEDDEEYND DDDDDDDDGF EDEAWTIRKS SAFAIDVLSG
IFPDAEYLSV TLPLIEQRMN EQNPWPVRES AILALGAIAD GSKNGLAPHL SKVIPYLINT
LNDPKPLVRS ITCWTLSRYS YWIAQADGRD YLHPLVVNLL NRIVDNNKKV QEAACSAFAT
LEEEADLLLI PYLQMILVTF VNAFGKYQAK NLLILYDAIS TLAKVVGNEL NKPELINILV
PPLLQKFNAL DDSNKNLLPL LGCLNQVCSS IGAGLQNLIS LFFNRSIKLI EGSLQAHYKY
NNQDQKGSSS SSDQDFIVAA LDLLQGLSEG IGTSIESLIP NSNLPHLLLQ CMNLRGSDVL
QSSFALLGDM SKFCLIHFKQ YIPDYLNILT NNLYPEYLSV CNNASWAIGE IAIRMPDEVK
PFVVAIRDRL ISNINKVNLN RGVLENTAVT IGRLGIVSPA DISPFVDKFI QCWCMAIRRK
TDDIEKDSAF RGMWLIINNN PNGALRHLVY ICDAVASWDK MQPDLYEAYF KLLHMYKTSM
GGVWAQFYNQ FPEQLREILN EKFKLNQDIS Q
