BTG3_MOUSE
ID BTG3_MOUSE Reviewed; 252 AA.
AC P50615; Q62328;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Protein BTG3;
DE AltName: Full=Abundant in neuroepithelium area protein;
DE AltName: Full=BTG family member 3;
DE AltName: Full=Protein Tob5;
GN Name=Btg3; Synonyms=Ana, Tob5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Embryo;
RX PubMed=9067576; DOI=10.1038/sj.leu.2400599;
RA Guehenneux F., Duret L., Callanan M.B., Bouhas R., Hayette S., Berthet C.,
RA Samarut C., Rimokh R., Birot A.-M., Wang Q., Magaud J.-P., Rouault J.-P.;
RT "Cloning of the mouse BTG3 gene and definition of a new gene family (the
RT BTG family) involved in the negative control of the cell cycle.";
RL Leukemia 11:370-375(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RX PubMed=9632145; DOI=10.1038/sj.onc.1201805;
RA Yoshida Y., Matsuda S., Ikematsu N., Kawamura-Tsuzuku J., Inazawa J.,
RA Umemori H., Yamamoto T.;
RT "ANA, a novel member of Tob/BTG1 family, is expressed in the ventricular
RT zone of the developing central nervous system.";
RL Oncogene 16:2687-2693(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Overexpression impairs serum-induced cell cycle progression
CC from the G0/G1 to S phase.
CC -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:9067576}.
CC -!- SIMILARITY: Belongs to the BTG family. {ECO:0000305}.
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DR EMBL; Z72000; CAA96519.1; -; mRNA.
DR EMBL; D83745; BAA29058.1; -; mRNA.
DR EMBL; BC012705; AAH12705.1; -; mRNA.
DR CCDS; CCDS28277.1; -.
DR RefSeq; NP_001284676.1; NM_001297747.1.
DR RefSeq; NP_033900.1; NM_009770.3.
DR AlphaFoldDB; P50615; -.
DR SMR; P50615; -.
DR BioGRID; 198399; 1.
DR DIP; DIP-61989N; -.
DR IntAct; P50615; 1.
DR STRING; 10090.ENSMUSP00000023570; -.
DR PhosphoSitePlus; P50615; -.
DR PaxDb; P50615; -.
DR PRIDE; P50615; -.
DR ProteomicsDB; 273714; -.
DR Antibodypedia; 5926; 133 antibodies from 24 providers.
DR Ensembl; ENSMUST00000023570; ENSMUSP00000023570; ENSMUSG00000022863.
DR GeneID; 12228; -.
DR KEGG; mmu:12228; -.
DR UCSC; uc007zsp.2; mouse.
DR CTD; 10950; -.
DR MGI; MGI:109532; Btg3.
DR VEuPathDB; HostDB:ENSMUSG00000022863; -.
DR eggNOG; KOG4006; Eukaryota.
DR GeneTree; ENSGT00950000182952; -.
DR HOGENOM; CLU_079660_3_0_1; -.
DR InParanoid; P50615; -.
DR OMA; HYGYRPR; -.
DR OrthoDB; 1455216at2759; -.
DR PhylomeDB; P50615; -.
DR TreeFam; TF105272; -.
DR BioGRID-ORCS; 12228; 3 hits in 74 CRISPR screens.
DR ChiTaRS; Btg3; mouse.
DR PRO; PR:P50615; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; P50615; protein.
DR Bgee; ENSMUSG00000022863; Expressed in pancreas and 128 other tissues.
DR ExpressionAtlas; P50615; baseline and differential.
DR Genevisible; P50615; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0045930; P:negative regulation of mitotic cell cycle; ISO:MGI.
DR Gene3D; 3.90.640.90; -; 1.
DR InterPro; IPR002087; Anti_prolifrtn.
DR InterPro; IPR033332; BTG.
DR InterPro; IPR036054; BTG-like_sf.
DR PANTHER; PTHR22978; PTHR22978; 1.
DR Pfam; PF07742; BTG; 1.
DR PRINTS; PR00310; ANTIPRLFBTG1.
DR SMART; SM00099; btg1; 1.
DR SUPFAM; SSF160696; SSF160696; 1.
DR PROSITE; PS00960; BTG_1; 1.
DR PROSITE; PS01203; BTG_2; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..252
FT /note="Protein BTG3"
FT /id="PRO_0000143808"
FT REGION 138..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 252 AA; 28983 MW; 15C4F8EFFF3B4A24 CRC64;
MKNEIAAVVF FFTRLVRKHD KLKKEAVERF AEKLTQILQE KYKNHWYPEK PSKGQAYRCI
RVNKFQRVDP DVLKACENSC ILYSDLGLPK ELTLWVDPCE VCCRYGEKNN AFIVASFENE
DENKDEISKK VSRALDKVTS DYHSGSSSSD EDTSKEVDVK PSSVAATPSP VYQISELIFP
PLPMWHPLPR KKPGMYRGSG HQTHYPPPVP FAYPNPGRKN KPFRPIPVTW VPPPGMHCDR
NHWINPHMLA PH
