位置:首页 > 蛋白库 > TNR22_MOUSE
TNR22_MOUSE
ID   TNR22_MOUSE             Reviewed;         198 AA.
AC   Q9ER62; Q8VHB9; Q9CZA4;
DT   27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   27-JUN-2003, sequence version 3.
DT   03-AUG-2022, entry version 142.
DE   RecName: Full=Tumor necrosis factor receptor superfamily member 22;
DE   AltName: Full=Decoy TRAIL receptor 2;
DE   AltName: Full=TNF receptor family member SOBa;
DE   AltName: Full=TNF receptor homolog 2;
DE   AltName: Full=Tumor necrosis factor receptor p60 homolog 2;
GN   Name=Tnfrsf22; Synonyms=Dctrailr2, Tnfrh2, Tnfrsf1al2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2).
RC   STRAIN=129/Sv; TISSUE=Embryonic stem cell;
RX   PubMed=11063728; DOI=10.1093/hmg/9.18.2691;
RA   Engemann S., Stroedicke M., Paulsen M., Franck O., Reinhardt R., Lane N.,
RA   Reik W., Walter J.;
RT   "Sequence and functional comparison in the Beckwith-Wiedemann region:
RT   implications for a novel imprinting centre and extended imprinting.";
RL   Hum. Mol. Genet. 9:2691-2706(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, AND 3D-STRUCTURE
RP   MODELING OF 62-170.
RC   STRAIN=NIH Swiss;
RX   PubMed=12466268; DOI=10.1074/jbc.m210783200;
RA   Schneider P., Olson D., Tardivel A., Browning B., Lugovskoy A., Gong D.,
RA   Dobles M., Hertig S., Hofmann K., Van Vlijmen H., Hsu Y.-M., Burkly L.C.,
RA   Tschopp J., Zheng T.S.;
RT   "Identification of a new murine tumor necrosis factor receptor locus that
RT   contains two novel murine receptors for tumor necrosis factor-related
RT   apoptosis-inducing ligand (TRAIL).";
RL   J. Biol. Chem. 278:5444-5454(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE (ISOFORM 1).
RA   Risser P., Mao W., Baldwin D.T., Pan G.;
RT   "Characterization of SOBa, a murine member of the TNFR family.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=C57BL/6J; TISSUE=Embryo;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
CC   -!- FUNCTION: Receptor for the cytotoxic ligand TNFSF10/TRAIL. Lacks a
CC       cytoplasmic death domain and hence is not capable of inducing
CC       apoptosis. Protects cells against TRAIL mediated apoptosis possibly
CC       through ligand competition. Cannot induce the NF-kappa-B pathway.
CC       {ECO:0000269|PubMed:12466268}.
CC   -!- SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000305}; Single-
CC       pass type II membrane protein {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9ER62-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9ER62-2; Sequence=VSP_007648;
CC   -!- TISSUE SPECIFICITY: Ubiquitous.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB28502.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=CAC16406.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=CAC27353.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ278265; CAC16406.1; ALT_FRAME; mRNA.
DR   EMBL; AJ276505; CAC27353.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AY165626; AAN87806.1; -; mRNA.
DR   EMBL; AY165627; AAN87807.1; -; mRNA.
DR   EMBL; AY046551; AAL05073.1; -; mRNA.
DR   EMBL; AK012838; BAB28502.2; ALT_INIT; mRNA.
DR   CCDS; CCDS22043.1; -. [Q9ER62-2]
DR   CCDS; CCDS80846.1; -. [Q9ER62-1]
DR   RefSeq; NP_001298074.1; NM_001311145.1. [Q9ER62-1]
DR   RefSeq; NP_076169.2; NM_023680.4. [Q9ER62-2]
DR   AlphaFoldDB; Q9ER62; -.
DR   SMR; Q9ER62; -.
DR   STRING; 10090.ENSMUSP00000075018; -.
DR   GlyGen; Q9ER62; 2 sites.
DR   EPD; Q9ER62; -.
DR   MaxQB; Q9ER62; -.
DR   PaxDb; Q9ER62; -.
DR   PRIDE; Q9ER62; -.
DR   ProteomicsDB; 259481; -. [Q9ER62-1]
DR   ProteomicsDB; 259482; -. [Q9ER62-2]
DR   DNASU; 79202; -.
DR   Ensembl; ENSMUST00000075588; ENSMUSP00000075018; ENSMUSG00000010751. [Q9ER62-1]
DR   Ensembl; ENSMUST00000084396; ENSMUSP00000081432; ENSMUSG00000010751. [Q9ER62-2]
DR   Ensembl; ENSMUST00000146692; ENSMUSP00000119297; ENSMUSG00000010751. [Q9ER62-2]
DR   GeneID; 79202; -.
DR   KEGG; mmu:79202; -.
DR   UCSC; uc009kps.1; mouse. [Q9ER62-2]
DR   UCSC; uc009kpt.1; mouse. [Q9ER62-1]
DR   CTD; 79202; -.
DR   MGI; MGI:1930270; Tnfrsf22.
DR   VEuPathDB; HostDB:ENSMUSG00000010751; -.
DR   eggNOG; ENOG502RBEC; Eukaryota.
DR   GeneTree; ENSGT00930000151070; -.
DR   HOGENOM; CLU_130470_0_0_1; -.
DR   InParanoid; Q9ER62; -.
DR   OMA; NECTETA; -.
DR   OrthoDB; 1457206at2759; -.
DR   PhylomeDB; Q9ER62; -.
DR   TreeFam; TF333916; -.
DR   BioGRID-ORCS; 79202; 2 hits in 70 CRISPR screens.
DR   ChiTaRS; Tnfrsf22; mouse.
DR   PRO; PR:Q9ER62; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; Q9ER62; protein.
DR   Bgee; ENSMUSG00000010751; Expressed in embryonic post-anal tail and 82 other tissues.
DR   ExpressionAtlas; Q9ER62; baseline and differential.
DR   Genevisible; Q9ER62; MM.
DR   GO; GO:0009986; C:cell surface; ISO:MGI.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045121; C:membrane raft; ISO:MGI.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR   GO; GO:0002020; F:protease binding; ISO:MGI.
DR   GO; GO:0045569; F:TRAIL binding; IDA:UniProtKB.
DR   GO; GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IDA:MGI.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IBA:GO_Central.
DR   GO; GO:0036462; P:TRAIL-activated apoptotic signaling pathway; IBA:GO_Central.
DR   CDD; cd15837; TNFRSF26; 1.
DR   InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR   InterPro; IPR034062; TNFRSF26_N.
DR   Pfam; PF00020; TNFR_c6; 2.
DR   SMART; SM00208; TNFR; 3.
DR   PROSITE; PS00652; TNFR_NGFR_1; 3.
DR   PROSITE; PS50050; TNFR_NGFR_2; 2.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW   Membrane; Receptor; Reference proteome; Repeat; Secreted; Signal-anchor;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..198
FT                   /note="Tumor necrosis factor receptor superfamily member
FT                   22"
FT                   /id="PRO_0000058937"
FT   TOPO_DOM        1..20
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        21..41
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        42..198
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REPEAT          47..82
FT                   /note="TNFR-Cys 1"
FT   REPEAT          84..124
FT                   /note="TNFR-Cys 2"
FT   REPEAT          125..165
FT                   /note="TNFR-Cys 3"
FT   CARBOHYD        62
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        158
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        48..59
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        60..73
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        63..82
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        85..100
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        103..116
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        106..124
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        126..141
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        144..157
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        147..165
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   VAR_SEQ         171..198
FT                   /note="NPRNRLFLLLSPLSVLIVSVVVFRIIRR -> RRSASVAWPI (in
FT                   isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:11063728,
FT                   ECO:0000303|PubMed:12466268, ECO:0000303|PubMed:16141072"
FT                   /id="VSP_007648"
FT   CONFLICT        12
FT                   /note="L -> V (in Ref. 2; AAL05073)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        24
FT                   /note="L -> C (in Ref. 1; CAC16406)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        27..30
FT                   /note="LLLL -> CVV (in Ref. 1; CAC16406)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   198 AA;  22375 MW;  EBF8F52961EA9983 CRC64;
     MFGFFCSLVS SLSRWFLWRR LLLLLLLLLL NLPLQVKFAM LELHSFKCPA GEYWSKDVCC
     KNCSAGTFVK APCEIPHTQG QCEKCHPGTF TEKDNYLDAC ILCSTCDKDQ EMVADCSATS
     DRKCQCRTGL YYYDPKFPES CRPCTKCPQG IPVLQECNST ANTVCSSSVS NPRNRLFLLL
     SPLSVLIVSV VVFRIIRR
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024