TNR23_MOUSE
ID TNR23_MOUSE Reviewed; 176 AA.
AC Q9ER63; Q8VHC0;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 27-MAY-2002, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Tumor necrosis factor receptor superfamily member 23;
DE AltName: Full=Decoy TRAIL receptor 1;
DE AltName: Full=TNF receptor family member SOB;
DE AltName: Full=TNF receptor homolog 1;
DE AltName: Full=Tumor necrosis factor receptor p60 homolog 1;
DE Flags: Precursor;
GN Name=Tnfrsf23; Synonyms=Dctrailr1, Tnfrh1, Tnfrsf1al1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=129/Sv; TISSUE=Embryonic stem cell;
RX PubMed=11063728; DOI=10.1093/hmg/9.18.2691;
RA Engemann S., Stroedicke M., Paulsen M., Franck O., Reinhardt R., Lane N.,
RA Reik W., Walter J.;
RT "Sequence and functional comparison in the Beckwith-Wiedemann region:
RT implications for a novel imprinting centre and extended imprinting.";
RL Hum. Mol. Genet. 9:2691-2706(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND
RP 3D-STRUCTURE MODELING OF 52-160.
RC STRAIN=C57BL/6J;
RX PubMed=12466268; DOI=10.1074/jbc.m210783200;
RA Schneider P., Olson D., Tardivel A., Browning B., Lugovskoy A., Gong D.,
RA Dobles M., Hertig S., Hofmann K., Van Vlijmen H., Hsu Y.-M., Burkly L.C.,
RA Tschopp J., Zheng T.S.;
RT "Identification of a new murine tumor necrosis factor receptor locus that
RT contains two novel murine receptors for tumor necrosis factor-related
RT apoptosis-inducing ligand (TRAIL).";
RL J. Biol. Chem. 278:5444-5454(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE.
RA Pan G., Mao W., Risser P.;
RT "Characterization of SOB, a member of the TNFR family.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic
CC death domain and hence is not capable of inducing apoptosis. May
CC protect cells against TRAIL mediated apoptosis through ligand
CC competition. Cannot induce the NF-kappa-B pathway.
CC {ECO:0000269|PubMed:12466268}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12466268};
CC Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12466268}.
CC -!- TISSUE SPECIFICITY: Ubiquitous.
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DR EMBL; AJ278264; CAC16405.1; -; mRNA.
DR EMBL; AJ276505; CAC27352.1; -; Genomic_DNA.
DR EMBL; AY165625; AAN87805.1; -; mRNA.
DR EMBL; AY046550; AAL05072.1; -; mRNA.
DR CCDS; CCDS22044.1; -.
DR RefSeq; NP_077252.2; NM_024290.4.
DR AlphaFoldDB; Q9ER63; -.
DR SMR; Q9ER63; -.
DR BioGRID; 219742; 3.
DR STRING; 10090.ENSMUSP00000116742; -.
DR GlyGen; Q9ER63; 1 site.
DR jPOST; Q9ER63; -.
DR MaxQB; Q9ER63; -.
DR PaxDb; Q9ER63; -.
DR PRIDE; Q9ER63; -.
DR ProteomicsDB; 259288; -.
DR DNASU; 79201; -.
DR Ensembl; ENSMUST00000152703; ENSMUSP00000116742; ENSMUSG00000037613.
DR GeneID; 79201; -.
DR KEGG; mmu:79201; -.
DR UCSC; uc009kpu.1; mouse.
DR CTD; 79201; -.
DR MGI; MGI:1930269; Tnfrsf23.
DR VEuPathDB; HostDB:ENSMUSG00000037613; -.
DR eggNOG; ENOG502RBEC; Eukaryota.
DR GeneTree; ENSGT00930000151070; -.
DR HOGENOM; CLU_130470_0_0_1; -.
DR InParanoid; Q9ER63; -.
DR OMA; CSITANT; -.
DR OrthoDB; 1457206at2759; -.
DR PhylomeDB; Q9ER63; -.
DR TreeFam; TF333916; -.
DR BioGRID-ORCS; 79201; 3 hits in 71 CRISPR screens.
DR PRO; PR:Q9ER63; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9ER63; protein.
DR Bgee; ENSMUSG00000037613; Expressed in decidua and 72 other tissues.
DR ExpressionAtlas; Q9ER63; baseline and differential.
DR Genevisible; Q9ER63; MM.
DR GO; GO:0031362; C:anchored component of external side of plasma membrane; IDA:MGI.
DR GO; GO:0031265; C:CD95 death-inducing signaling complex; IBA:GO_Central.
DR GO; GO:0009986; C:cell surface; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0045121; C:membrane raft; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0002020; F:protease binding; ISO:MGI.
DR GO; GO:0005031; F:tumor necrosis factor receptor activity; IBA:GO_Central.
DR GO; GO:0006924; P:activation-induced cell death of T cells; IBA:GO_Central.
DR GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IBA:GO_Central.
DR GO; GO:0097049; P:motor neuron apoptotic process; IBA:GO_Central.
DR GO; GO:0097527; P:necroptotic signaling pathway; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
DR GO; GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IDA:MGI.
DR GO; GO:2001269; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; IBA:GO_Central.
DR GO; GO:0032872; P:regulation of stress-activated MAPK cascade; IBA:GO_Central.
DR CDD; cd15837; TNFRSF26; 1.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR034062; TNFRSF26_N.
DR Pfam; PF00020; TNFR_c6; 3.
DR SMART; SM00208; TNFR; 3.
DR PROSITE; PS00652; TNFR_NGFR_1; 3.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein;
KW Membrane; Receptor; Reference proteome; Repeat; Signal.
FT SIGNAL 1..29
FT CHAIN 30..155
FT /note="Tumor necrosis factor receptor superfamily member
FT 23"
FT /id="PRO_0000034604"
FT PROPEP 156..176
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000034605"
FT REPEAT 37..72
FT /note="TNFR-Cys 1"
FT REPEAT 74..114
FT /note="TNFR-Cys 2"
FT REPEAT 115..155
FT /note="TNFR-Cys 3"
FT LIPID 155
FT /note="GPI-anchor amidated cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 148
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 38..49
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 50..63
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 53..72
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 75..90
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 93..106
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 96..114
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 116..131
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 134..147
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 137..155
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 176 AA; 19595 MW; EE30D617F49DDB7D CRC64;
MVTFSHVSSL SHWFLLLLLL NLFLPVIFAM PESYSFNCPD GEYQSNDVCC KTCPSGTFVK
APCKIPHTQG QCEKCHPGTF TGKDNGLHDC ELCSTCDKDQ NMVADCSATS DRKCECQIGL
YYYDPKFPES CRPCTKCPQG IPVLQECNST ANTVCSSSVS NPRNWLFLLM LIVFCI
