TNR26_MOUSE
ID TNR26_MOUSE Reviewed; 204 AA.
AC P83626;
DT 19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2003, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Tumor necrosis factor receptor superfamily member 26;
DE AltName: Full=TNF receptor homolog 3;
DE Flags: Precursor;
GN Name=Tnfrsf26; Synonyms=Tnfrh3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND 3D-STRUCTURE MODELING
RP OF 41-148.
RC STRAIN=C57BL/6J; TISSUE=Spleen;
RX PubMed=12466268; DOI=10.1074/jbc.m210783200;
RA Schneider P., Olson D., Tardivel A., Browning B., Lugovskoy A., Gong D.,
RA Dobles M., Hertig S., Hofmann K., Van Vlijmen H., Hsu Y.-M., Burkly L.C.,
RA Tschopp J., Zheng T.S.;
RT "Identification of a new murine tumor necrosis factor receptor locus that
RT contains two novel murine receptors for tumor necrosis factor-related
RT apoptosis-inducing ligand (TRAIL).";
RL J. Biol. Chem. 278:5444-5454(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in thymus and spleen. Detectable levels
CC in lung. {ECO:0000269|PubMed:12466268}.
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DR EMBL; AY165628; AAN87808.1; -; mRNA.
DR CCDS; CCDS40199.1; -.
DR RefSeq; NP_783580.1; NM_175649.5.
DR AlphaFoldDB; P83626; -.
DR SMR; P83626; -.
DR BioGRID; 232630; 1.
DR STRING; 10090.ENSMUSP00000054938; -.
DR GlyGen; P83626; 2 sites.
DR EPD; P83626; -.
DR PaxDb; P83626; -.
DR PRIDE; P83626; -.
DR ProteomicsDB; 260643; -.
DR DNASU; 244237; -.
DR Ensembl; ENSMUST00000055723; ENSMUSP00000054938; ENSMUSG00000045362.
DR GeneID; 244237; -.
DR KEGG; mmu:244237; -.
DR UCSC; uc009kpp.1; mouse.
DR CTD; 244237; -.
DR MGI; MGI:2651928; Tnfrsf26.
DR VEuPathDB; HostDB:ENSMUSG00000045362; -.
DR eggNOG; ENOG502TD2A; Eukaryota.
DR GeneTree; ENSGT00930000151070; -.
DR HOGENOM; CLU_107190_0_0_1; -.
DR InParanoid; P83626; -.
DR OMA; CNATMDT; -.
DR OrthoDB; 1457206at2759; -.
DR PhylomeDB; P83626; -.
DR TreeFam; TF333916; -.
DR BioGRID-ORCS; 244237; 1 hit in 72 CRISPR screens.
DR PRO; PR:P83626; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; P83626; protein.
DR Bgee; ENSMUSG00000045362; Expressed in granulocyte and 32 other tissues.
DR ExpressionAtlas; P83626; baseline and differential.
DR GO; GO:0009986; C:cell surface; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045121; C:membrane raft; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0002020; F:protease binding; ISO:MGI.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IBA:GO_Central.
DR GO; GO:0036462; P:TRAIL-activated apoptotic signaling pathway; IBA:GO_Central.
DR CDD; cd15837; TNFRSF26; 1.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR034062; TNFRSF26_N.
DR Pfam; PF00020; TNFR_c6; 2.
DR SMART; SM00208; TNFR; 3.
DR PROSITE; PS00652; TNFR_NGFR_1; 3.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome;
KW Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..204
FT /note="Tumor necrosis factor receptor superfamily member
FT 26"
FT /id="PRO_0000034607"
FT TOPO_DOM 20..164
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 186..204
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 27..61
FT /note="TNFR-Cys 1"
FT REPEAT 63..103
FT /note="TNFR-Cys 2"
FT REPEAT 104..143
FT /note="TNFR-Cys 3"
FT CARBOHYD 57
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 136
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 27..38
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 39..52
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 42..61
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 64..79
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 82..95
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 85..103
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 105..120
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 123..135
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 126..143
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 204 AA; 22708 MW; A35C5177F178C3DD CRC64;
MTRLRLLLLL GLLLRVAVCS VNTITLCKIG EFKHENLCCL QCSAGTYLRN PCQENHNKSE
CAPCDSEHFI DHKNRESECF PCSVCRDDQE EVAKCSRTAD RVCQCKQGTY CDSENCLERC
HTCSSCPDGR VVRKCNATMD TVCDKFDSEP GQSGSQCFCF SKPLGIVVII AAFIIIIGAV
IILILKIICY CKRGENIQLS STML
