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TNR4_MOUSE
ID   TNR4_MOUSE              Reviewed;         272 AA.
AC   P47741;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 154.
DE   RecName: Full=Tumor necrosis factor receptor superfamily member 4;
DE   AltName: Full=OX40 antigen;
DE   AltName: Full=OX40L receptor;
DE   AltName: CD_antigen=CD134;
DE   Flags: Precursor;
GN   Name=Tnfrsf4; Synonyms=Ox40, Txgp1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=BALB/cJ;
RX   PubMed=8228223;
RA   Calderhead D.M., Buhlmann J.E., van den Eertwegh A.J., Claassen E.,
RA   Noelle R.J., Fell H.;
RT   "Cloning of mouse Ox40: a T cell activation marker that may mediate T-B
RT   cell interactions.";
RL   J. Immunol. 151:5261-5271(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7737295; DOI=10.1002/eji.1830250410;
RA   Birkeland M.L., Copeland N.G., Gilbert D.J., Jenkins N.A., Barclay A.N.;
RT   "Gene structure and chromosomal localization of the mouse homologue of rat
RT   OX40 protein.";
RL   Eur. J. Immunol. 25:926-930(1995).
RN   [3]
RP   TISSUE SPECIFICITY, AND INDUCTION.
RX   PubMed=29244194; DOI=10.1002/eji.201747109;
RA   Hanieh H., Masuda K., Metwally H., Chalise J.P., Mohamed M., Nyati K.K.,
RA   Standley D.M., Li S., Higa M., Zaman M.M., Kishimoto T.;
RT   "Arid5a stabilizes OX40 mRNA in murine CD4+ T cells by recognizing a stem-
RT   loop structure in its 3'UTR.";
RL   Eur. J. Immunol. 48:593-604(2018).
CC   -!- FUNCTION: Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule
CC       implicated in long-term T-cell immunity (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with TRAF2, TRAF3 and TRAF5. {ECO:0000250}.
CC   -!- INTERACTION:
CC       P47741; P39429: Traf2; NbExp=12; IntAct=EBI-520001, EBI-520016;
CC       P47741; P62991: Ubc; NbExp=3; IntAct=EBI-520001, EBI-413074;
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed in CD4(+) T-cells and in T-helper Th17
CC       cells (at protein level). {ECO:0000269|PubMed:29244194}.
CC   -!- INDUCTION: By IL6/STAT3 signaling in T-helper Th17 cells.
CC       {ECO:0000269|PubMed:29244194}.
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DR   EMBL; Z21674; CAA79772.1; -; mRNA.
DR   EMBL; X85214; CAA59476.1; -; Genomic_DNA.
DR   CCDS; CCDS19055.1; -.
DR   PIR; I48700; I48700.
DR   RefSeq; NP_035789.1; NM_011659.2.
DR   AlphaFoldDB; P47741; -.
DR   SMR; P47741; -.
DR   BioGRID; 204386; 1.
DR   DIP; DIP-6239N; -.
DR   IntAct; P47741; 13.
DR   STRING; 10090.ENSMUSP00000030952; -.
DR   GlyGen; P47741; 1 site.
DR   PhosphoSitePlus; P47741; -.
DR   EPD; P47741; -.
DR   PaxDb; P47741; -.
DR   PRIDE; P47741; -.
DR   DNASU; 22163; -.
DR   GeneID; 22163; -.
DR   KEGG; mmu:22163; -.
DR   CTD; 7293; -.
DR   MGI; MGI:104512; Tnfrsf4.
DR   eggNOG; ENOG502SB1F; Eukaryota.
DR   InParanoid; P47741; -.
DR   OrthoDB; 1081476at2759; -.
DR   PhylomeDB; P47741; -.
DR   Reactome; R-MMU-5669034; TNFs bind their physiological receptors.
DR   BioGRID-ORCS; 22163; 5 hits in 77 CRISPR screens.
DR   PRO; PR:P47741; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P47741; protein.
DR   GO; GO:0009986; C:cell surface; ISO:MGI.
DR   GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR   GO; GO:0005031; F:tumor necrosis factor receptor activity; IPI:MGI.
DR   GO; GO:0006968; P:cellular defense response; IMP:MGI.
DR   GO; GO:0006954; P:inflammatory response; IMP:MGI.
DR   GO; GO:0070236; P:negative regulation of activation-induced cell death of T cells; IMP:BHF-UCL.
DR   GO; GO:0001818; P:negative regulation of cytokine production; IPI:MGI.
DR   GO; GO:0043433; P:negative regulation of DNA-binding transcription factor activity; IDA:BHF-UCL.
DR   GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IMP:BHF-UCL.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:BHF-UCL.
DR   GO; GO:0030890; P:positive regulation of B cell proliferation; IMP:BHF-UCL.
DR   GO; GO:0002639; P:positive regulation of immunoglobulin production; IDA:BHF-UCL.
DR   GO; GO:0042981; P:regulation of apoptotic process; IMP:MGI.
DR   GO; GO:0045859; P:regulation of protein kinase activity; IMP:MGI.
DR   GO; GO:0042098; P:T cell proliferation; ISO:MGI.
DR   CDD; cd13406; TNFRSF4; 1.
DR   InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR   InterPro; IPR020445; TNFR_4.
DR   InterPro; IPR034022; TNFRSF4_N.
DR   PANTHER; PTHR47881; PTHR47881; 1.
DR   Pfam; PF00020; TNFR_c6; 2.
DR   PRINTS; PR01921; TNFACTORR4.
DR   SMART; SM00208; TNFR; 3.
DR   PROSITE; PS00652; TNFR_NGFR_1; 2.
DR   PROSITE; PS50050; TNFR_NGFR_2; 2.
PE   1: Evidence at protein level;
KW   Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome;
KW   Repeat; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..272
FT                   /note="Tumor necrosis factor receptor superfamily member 4"
FT                   /id="PRO_0000034555"
FT   TOPO_DOM        20..211
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        212..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        237..272
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REPEAT          26..61
FT                   /note="TNFR-Cys 1"
FT   REPEAT          62..103
FT                   /note="TNFR-Cys 2"
FT   REPEAT          104..124
FT                   /note="TNFR-Cys 3; truncated"
FT   REPEAT          125..165
FT                   /note="TNFR-Cys 4"
FT   CARBOHYD        144
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        27..38
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        39..52
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        42..60
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        63..77
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        80..95
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        83..103
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        105..123
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        126..139
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        145..164
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   CONFLICT        15
FT                   /note="A -> G (in Ref. 2; CAA59476)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   272 AA;  30154 MW;  06E7BB4156F0D08E CRC64;
     MYVWVQQPTA LLLLALTLGV TARRLNCVKH TYPSGHKCCR ECQPGHGMVS RCDHTRDTLC
     HPCETGFYNE AVNYDTCKQC TQCNHRSGSE LKQNCTPTQD TVCRCRPGTQ PRQDSGYKLG
     VDCVPCPPGH FSPGNNQACK PWTNCTLSGK QTRHPASDSL DAVCEDRSLL ATLLWETQRP
     TFRPTTVQST TVWPRTSELP SPPTLVTPEG PAFAVLLGLG LGLLAPLTVL LALYLLRKAW
     RLPNTPKPCW GNSFRTPIQE EHTDAHFTLA KI
 
 
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