TNR4_RAT
ID TNR4_RAT Reviewed; 271 AA.
AC P15725;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Tumor necrosis factor receptor superfamily member 4;
DE AltName: Full=MRC OX40;
DE AltName: Full=OX40 antigen;
DE AltName: Full=OX40L receptor;
DE AltName: CD_antigen=CD134;
DE Flags: Precursor;
GN Name=Tnfrsf4; Synonyms=Ox40, Txgp1l;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=T-cell;
RX PubMed=2157591; DOI=10.1002/j.1460-2075.1990.tb08211.x;
RA Mallett S., Fossum S., Barclay A.N.;
RT "Characterization of the MRC OX40 antigen of activated CD4 positive T
RT lymphocytes -- a molecule related to nerve growth factor receptor.";
RL EMBO J. 9:1063-1068(1990).
CC -!- FUNCTION: Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule
CC implicated in long-term T-cell immunity (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with TRAF2, TRAF3 and TRAF5. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC -!- TISSUE SPECIFICITY: Activated T-cells.
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DR EMBL; X17037; CAA34897.1; -; mRNA.
DR PIR; S12783; S12783.
DR RefSeq; NP_037181.1; NM_013049.1.
DR AlphaFoldDB; P15725; -.
DR SMR; P15725; -.
DR IntAct; P15725; 1.
DR STRING; 10116.ENSRNOP00000027251; -.
DR GlyGen; P15725; 1 site.
DR PaxDb; P15725; -.
DR PRIDE; P15725; -.
DR Ensembl; ENSRNOT00000027251; ENSRNOP00000027251; ENSRNOG00000020106.
DR GeneID; 25572; -.
DR KEGG; rno:25572; -.
DR CTD; 7293; -.
DR RGD; 3920; Tnfrsf4.
DR eggNOG; ENOG502SB1F; Eukaryota.
DR GeneTree; ENSGT00730000111452; -.
DR HOGENOM; CLU_092451_0_0_1; -.
DR InParanoid; P15725; -.
DR OMA; HFSPGDD; -.
DR OrthoDB; 1081476at2759; -.
DR PhylomeDB; P15725; -.
DR TreeFam; TF330135; -.
DR Reactome; R-RNO-5669034; TNFs bind their physiological receptors.
DR PRO; PR:P15725; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Bgee; ENSRNOG00000020106; Expressed in thymus and 18 other tissues.
DR Genevisible; P15725; RN.
DR GO; GO:0009986; C:cell surface; IMP:BHF-UCL.
DR GO; GO:0009897; C:external side of plasma membrane; ISO:RGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR GO; GO:0005031; F:tumor necrosis factor receptor activity; ISO:RGD.
DR GO; GO:0006968; P:cellular defense response; ISO:RGD.
DR GO; GO:0006954; P:inflammatory response; ISO:RGD.
DR GO; GO:0070236; P:negative regulation of activation-induced cell death of T cells; ISO:RGD.
DR GO; GO:0001818; P:negative regulation of cytokine production; ISO:RGD.
DR GO; GO:0043433; P:negative regulation of DNA-binding transcription factor activity; ISO:RGD.
DR GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; ISO:RGD.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:RGD.
DR GO; GO:0030890; P:positive regulation of B cell proliferation; ISO:RGD.
DR GO; GO:0002639; P:positive regulation of immunoglobulin production; ISO:RGD.
DR GO; GO:0042981; P:regulation of apoptotic process; ISO:RGD.
DR GO; GO:0045859; P:regulation of protein kinase activity; ISO:RGD.
DR GO; GO:0042098; P:T cell proliferation; IMP:BHF-UCL.
DR CDD; cd13406; TNFRSF4; 1.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR020445; TNFR_4.
DR InterPro; IPR034022; TNFRSF4_N.
DR PANTHER; PTHR47881; PTHR47881; 1.
DR Pfam; PF00020; TNFR_c6; 3.
DR PRINTS; PR01921; TNFACTORR4.
DR SMART; SM00208; TNFR; 3.
DR PROSITE; PS00652; TNFR_NGFR_1; 2.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome;
KW Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..271
FT /note="Tumor necrosis factor receptor superfamily member 4"
FT /id="PRO_0000034556"
FT TOPO_DOM 20..210
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..235
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 236..271
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 25..60
FT /note="TNFR-Cys 1"
FT REPEAT 61..102
FT /note="TNFR-Cys 2"
FT REPEAT 103..123
FT /note="TNFR-Cys 3; truncated"
FT REPEAT 124..164
FT /note="TNFR-Cys 4"
FT CARBOHYD 143
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 26..37
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 38..51
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 41..59
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 62..76
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 79..94
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 82..102
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 104..122
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 125..138
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 144..163
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 271 AA; 29895 MW; C06465136B16E821 CRC64;
MYVWVQQPTA FLLLGLSLGV TVKLNCVKDT YPSGHKCCRE CQPGHGMVSR CDHTRDTVCH
PCEPGFYNEA VNYDTCKQCT QCNHRSGSEL KQNCTPTEDT VCQCRPGTQP RQDSSHKLGV
DCVPCPPGHF SPGSNQACKP WTNCTLSGKQ IRHPASNSLD TVCEDRSLLA TLLWETQRTT
FRPTTVPSTT VWPRTSQLPS TPTLVAPEGP AFAVILGLGL GLLAPLTVLL ALYLLRKAWR
SPNTPKPCWG NSFRTPIQEE QTDTHFTLAK I
