TNR5_BOVIN
ID TNR5_BOVIN Reviewed; 280 AA.
AC Q28203; A7YWS9;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 3.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Tumor necrosis factor receptor superfamily member 5;
DE AltName: Full=B-cell surface antigen CD40;
DE AltName: Full=CD40L receptor;
DE AltName: CD_antigen=CD40;
DE Flags: Precursor;
GN Name=CD40; Synonyms=TNFRSF5;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thymus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-270.
RC TISSUE=Peripheral blood lymphocyte;
RX PubMed=9135560; DOI=10.1046/j.1365-2567.1997.00159.x;
RA Hirano A., Brown W.C., Estes D.M.;
RT "Cloning, expression and biological function of the bovine CD40 homologue:
RT role in B-lymphocyte growth and differentiation in cattle.";
RL Immunology 90:294-300(1997).
CC -!- FUNCTION: Receptor for TNFSF5/CD40LG (By similarity). Transduces
CC TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and
CC B cells, leading to induction of immunoglobulin secretion (By
CC similarity). {ECO:0000250|UniProtKB:P25942,
CC ECO:0000250|UniProtKB:P27512}.
CC -!- SUBUNIT: Monomer and homodimer. Interacts with TRAF1, TRAF2, TRAF3,
CC TRAF5 and TRAF6. Interacts with TRAF6 and MAP3K8; the interaction is
CC required for ERK activation (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC48710.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; BC134765; AAI34766.1; -; mRNA.
DR EMBL; U57745; AAC48710.1; ALT_FRAME; mRNA.
DR RefSeq; NP_001099081.1; NM_001105611.2.
DR AlphaFoldDB; Q28203; -.
DR SMR; Q28203; -.
DR STRING; 9913.ENSBTAP00000027630; -.
DR PaxDb; Q28203; -.
DR PRIDE; Q28203; -.
DR Ensembl; ENSBTAT00000027630; ENSBTAP00000027630; ENSBTAG00000020736.
DR GeneID; 286849; -.
DR KEGG; bta:286849; -.
DR CTD; 958; -.
DR VEuPathDB; HostDB:ENSBTAG00000020736; -.
DR VGNC; VGNC:27033; CD40.
DR eggNOG; ENOG502S5TQ; Eukaryota.
DR GeneTree; ENSGT00940000161464; -.
DR InParanoid; Q28203; -.
DR OMA; CQPGEKL; -.
DR OrthoDB; 1038336at2759; -.
DR Proteomes; UP000009136; Chromosome 13.
DR Bgee; ENSBTAG00000020736; Expressed in retropharyngeal lymph node and 98 other tissues.
DR GO; GO:0035631; C:CD40 receptor complex; IBA:GO_Central.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0042113; P:B cell activation; IBA:GO_Central.
DR GO; GO:0019724; P:B cell mediated immunity; IEA:Ensembl.
DR GO; GO:0042100; P:B cell proliferation; IEA:Ensembl.
DR GO; GO:0023035; P:CD40 signaling pathway; IBA:GO_Central.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0042832; P:defense response to protozoan; IBA:GO_Central.
DR GO; GO:0051607; P:defense response to virus; IBA:GO_Central.
DR GO; GO:0002768; P:immune response-regulating cell surface receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IBA:GO_Central.
DR GO; GO:0030890; P:positive regulation of B cell proliferation; IBA:GO_Central.
DR GO; GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IBA:GO_Central.
DR GO; GO:2000353; P:positive regulation of endothelial cell apoptotic process; IBA:GO_Central.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR GO; GO:0032735; P:positive regulation of interleukin-12 production; IBA:GO_Central.
DR GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; IBA:GO_Central.
DR GO; GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl.
DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IBA:GO_Central.
DR GO; GO:0090037; P:positive regulation of protein kinase C signaling; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IBA:GO_Central.
DR GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR GO; GO:0034341; P:response to interferon-gamma; IBA:GO_Central.
DR GO; GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; IBA:GO_Central.
DR CDD; cd13407; TNFRSF5; 1.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR020435; TNFR_5.
DR InterPro; IPR034021; TNFRSF5_N.
DR PRINTS; PR01922; TNFACTORR5.
DR SMART; SM00208; TNFR; 4.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunity; Membrane; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..280
FT /note="Tumor necrosis factor receptor superfamily member 5"
FT /id="PRO_0000034557"
FT TOPO_DOM 21..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..280
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 25..60
FT /note="TNFR-Cys 1"
FT REPEAT 61..103
FT /note="TNFR-Cys 2"
FT REPEAT 104..144
FT /note="TNFR-Cys 3"
FT REPEAT 145..187
FT /note="TNFR-Cys 4"
FT REGION 225..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..242
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 153
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 180
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 26..37
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 38..51
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 41..59
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 62..77
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 83..103
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 105..119
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 111..116
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 125..143
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT CONFLICT 102
FT /note="T -> I (in Ref. 2; AAC48710)"
FT /evidence="ECO:0000305"
FT CONFLICT 230
FT /note="T -> M (in Ref. 2; AAC48710)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 280 AA; 31062 MW; 695ED038DCADFE29 CRC64;
MVRLPLQCLF WGFFLTAVHS EPATACGEKQ YPVNSLCCDL CPPGQKLVND CTEVSKTECQ
SCGKGEFLST WNREKYCHEH RYCNPNLGLR IQSEGTLNTD TTCVCVEGQH CTSHTCESCT
PHSLCLPGFG VKQIATGLLD TVCEPCPLGF FSNVSSAFEK CHRWTSCERK GLVEQHVGTN
KTDVVCGFQS RMRTLVVIPV TMGVLFAVLL VSACIRNITK KRQAKALHPT AERQDPVETI
DPEDFPGPHP PPPVQETLCW CQPVAQEDGK ESRISVQERE
