TNR5_CALJA
ID TNR5_CALJA Reviewed; 274 AA.
AC Q3LRP1;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Tumor necrosis factor receptor superfamily member 5;
DE AltName: Full=B-cell surface antigen CD40;
DE AltName: Full=CD40L receptor;
DE AltName: CD_antigen=CD40;
DE Flags: Precursor;
GN Name=CD40; Synonyms=TNFRSF5;
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=18577846; DOI=10.1620/tjem.215.167;
RA Kohu K., Yamabe E., Matsuzawa A., Onda D., Suemizu H., Sasaki E.,
RA Tanioka Y., Yagita H., Suzuki D., Kametani Y., Takai T., Toyoda A.,
RA Habu S., Satake M.;
RT "Comparison of 30 immunity-related genes from the common marmoset with
RT orthologues from human and mouse.";
RL Tohoku J. Exp. Med. 215:167-180(2008).
CC -!- FUNCTION: Receptor for TNFSF5/CD40LG (By similarity). Transduces
CC TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and
CC B cells, leading to induction of immunoglobulin secretion (By
CC similarity). {ECO:0000250|UniProtKB:P25942,
CC ECO:0000250|UniProtKB:P27512}.
CC -!- SUBUNIT: Monomer and homodimer. Interacts with TRAF1, TRAF2, TRAF3,
CC TRAF5 and TRAF6. Interacts with TRAF6 and MAP3K8; the interaction is
CC required for ERK activation (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
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DR EMBL; DQ189221; ABA29632.1; -; mRNA.
DR RefSeq; NP_001254659.1; NM_001267730.1.
DR AlphaFoldDB; Q3LRP1; -.
DR SMR; Q3LRP1; -.
DR STRING; 9483.ENSCJAP00000031479; -.
DR PRIDE; Q3LRP1; -.
DR Ensembl; ENSCJAT00000083281; ENSCJAP00000054885; ENSCJAG00000017119.
DR GeneID; 100385800; -.
DR KEGG; cjc:100385800; -.
DR CTD; 958; -.
DR eggNOG; ENOG502S5TQ; Eukaryota.
DR GeneTree; ENSGT00940000161464; -.
DR InParanoid; Q3LRP1; -.
DR OrthoDB; 1038336at2759; -.
DR Proteomes; UP000008225; Chromosome 5.
DR Bgee; ENSCJAG00000017119; Expressed in testis and 6 other tissues.
DR GO; GO:0035631; C:CD40 receptor complex; IEA:Ensembl.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0019724; P:B cell mediated immunity; IEA:Ensembl.
DR GO; GO:0042100; P:B cell proliferation; IEA:Ensembl.
DR GO; GO:0023035; P:CD40 signaling pathway; IEA:Ensembl.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR GO; GO:0042832; P:defense response to protozoan; IEA:Ensembl.
DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR GO; GO:0002768; P:immune response-regulating cell surface receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
DR GO; GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IEA:Ensembl.
DR GO; GO:2000353; P:positive regulation of endothelial cell apoptotic process; IEA:Ensembl.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
DR GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
DR GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; IEA:Ensembl.
DR GO; GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl.
DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR GO; GO:0090037; P:positive regulation of protein kinase C signaling; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
DR GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR CDD; cd13407; TNFRSF5; 1.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR020435; TNFR_5.
DR InterPro; IPR034021; TNFRSF5_N.
DR Pfam; PF00020; TNFR_c6; 1.
DR PRINTS; PR01922; TNFACTORR5.
DR SMART; SM00208; TNFR; 4.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 4.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunity; Membrane; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..274
FT /note="Tumor necrosis factor receptor superfamily member 5"
FT /id="PRO_0000252694"
FT TOPO_DOM 21..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..274
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 25..60
FT /note="TNFR-Cys 1"
FT REPEAT 61..103
FT /note="TNFR-Cys 2"
FT REPEAT 104..144
FT /note="TNFR-Cys 3"
FT REPEAT 145..187
FT /note="TNFR-Cys 4"
FT REGION 224..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 153
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 26..37
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 38..51
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 41..59
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 62..77
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 83..103
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 105..119
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 111..116
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 125..143
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 274 AA; 30390 MW; F32BF73FC6796B79 CRC64;
MFRLPLQCVL WGCLLSSVHP EPPTACREKQ YLINSQCCSL CQPGWKLVND CTEVTETECL
PCGKGEFLDT WNRETHCHQH KYCDPNLGLR VQQEGTSVTD NICVCKEGRH CTSKACESCV
LYHSCSPGFG VKQIATGVSD TICEPCPVGF FSNVSSAFEK CRPWTRCETK GLAEQQAGTD
KTDAVCGPQN RLRLLVVIPI MLGILFAILL VLVFIKKVDR KPQDKAPCTK QIPQEIDDLP
GPNPTPPVQE TLHGCQPVAQ EDGKESRISV QERQ
