ID   TNR5_CANLF              Reviewed;         274 AA.
AC   Q7YRL5;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Tumor necrosis factor receptor superfamily member 5;
DE   AltName: Full=B-cell surface antigen CD40;
DE   AltName: Full=CD40L receptor;
DE   AltName: CD_antigen=CD40;
DE   Flags: Precursor;
GN   Name=CD40; Synonyms=TNFRSF5;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Yang S., Sim G.-K.;
RT   "Canine CD40 and CD40 ligand cDNA sequences.";
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for TNFSF5/CD40LG (By similarity). Transduces
CC       TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and
CC       B cells, leading to induction of immunoglobulin secretion (By
CC       similarity). {ECO:0000250|UniProtKB:P25942,
CC       ECO:0000250|UniProtKB:P27512}.
CC   -!- SUBUNIT: Monomer and homodimer. Interacts with TRAF1, TRAF2, TRAF3,
CC       TRAF5 and TRAF6. Interacts with TRAF6 and MAP3K8; the interaction is
CC       required for ERK activation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
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DR   EMBL; AY333789; AAP86653.1; -; mRNA.
DR   RefSeq; NP_001002982.1; NM_001002982.1.
DR   AlphaFoldDB; Q7YRL5; -.
DR   SMR; Q7YRL5; -.
DR   STRING; 9615.ENSCAFP00000061346; -.
DR   PaxDb; Q7YRL5; -.
DR   GeneID; 403469; -.
DR   KEGG; cfa:403469; -.
DR   CTD; 958; -.
DR   eggNOG; ENOG502S5TQ; Eukaryota.
DR   InParanoid; Q7YRL5; -.
DR   OrthoDB; 1038336at2759; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0009897; C:external side of plasma membrane; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   GO; GO:0042113; P:B cell activation; IEA:InterPro.
DR   GO; GO:0050776; P:regulation of immune response; IEA:InterPro.
DR   CDD; cd13407; TNFRSF5; 1.
DR   InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR   InterPro; IPR020435; TNFR_5.
DR   InterPro; IPR034021; TNFRSF5_N.
DR   Pfam; PF00020; TNFR_c6; 2.
DR   PRINTS; PR01922; TNFACTORR5.
DR   SMART; SM00208; TNFR; 4.
DR   PROSITE; PS00652; TNFR_NGFR_1; 1.
DR   PROSITE; PS50050; TNFR_NGFR_2; 3.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Immunity; Membrane; Receptor;
KW   Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..274
FT                   /note="Tumor necrosis factor receptor superfamily member 5"
FT                   /id="PRO_0000034558"
FT   TOPO_DOM        21..194
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        216..274
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REPEAT          25..60
FT                   /note="TNFR-Cys 1"
FT   REPEAT          61..103
FT                   /note="TNFR-Cys 2"
FT   REPEAT          104..144
FT                   /note="TNFR-Cys 3"
FT   REPEAT          145..187
FT                   /note="TNFR-Cys 4"
FT   CARBOHYD        153
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        180
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        26..37
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        38..51
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        41..59
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        62..77
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        83..103
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        105..119
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        111..116
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        125..143
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
SQ   SEQUENCE   274 AA;  30284 MW;  9723789A07FAB6DB CRC64;
     MVLLPLRCLF WGSLLTTVYP EPRTACREKQ YLVDSQCCNM CPPGEKLVND CLHTIDTECT
     RCQTGEFLDT WNAERHCHQH KYCDPNLGLH VEKEGTSETD TTCTCDEGLH CTNAACESCT
     MHSLCPPGLG VKQIATGISD TICDPCPIGF FSNVSSALEK CHPWTSCETK GLVKVQAGTN
     KTDVICGPQP RLRALVVVPI IMGILLVVLL VSACIRKVVK KPENKVMYQD PVEDLEEFPM
     PPHSIAPVQE TLHGCQPVTQ EDGKESRISV QERV