TNR5_HORSE
ID TNR5_HORSE Reviewed; 280 AA.
AC Q3ZTK5;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Tumor necrosis factor receptor superfamily member 5;
DE AltName: Full=B-cell surface antigen CD40;
DE AltName: Full=CD40L receptor;
DE AltName: CD_antigen=CD40;
DE Flags: Precursor;
GN Name=CD40; Synonyms=TNFRSF5;
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Wagner B., Antczak D.F.;
RT "The CD40 gene of the horse.";
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for TNFSF5/CD40LG (By similarity). Transduces
CC TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and
CC B cells, leading to induction of immunoglobulin secretion (By
CC similarity). {ECO:0000250|UniProtKB:P25942,
CC ECO:0000250|UniProtKB:P27512}.
CC -!- SUBUNIT: Monomer and homodimer. Interacts with TRAF1, TRAF2, TRAF3,
CC TRAF5 and TRAF6. Interacts with TRAF6 and MAP3K8; the interaction is
CC required for ERK activation (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
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DR EMBL; AY514017; AAS82955.1; -; mRNA.
DR RefSeq; NP_001075371.1; NM_001081902.1.
DR AlphaFoldDB; Q3ZTK5; -.
DR SMR; Q3ZTK5; -.
DR STRING; 9796.ENSECAP00000014907; -.
DR PaxDb; Q3ZTK5; -.
DR Ensembl; ENSECAT00000018286; ENSECAP00000014907; ENSECAG00000016998.
DR GeneID; 100034049; -.
DR KEGG; ecb:100034049; -.
DR CTD; 958; -.
DR VGNC; VGNC:16268; CD40.
DR GeneTree; ENSGT00940000161464; -.
DR HOGENOM; CLU_052667_4_0_1; -.
DR InParanoid; Q3ZTK5; -.
DR OMA; CQPGEKL; -.
DR OrthoDB; 1038336at2759; -.
DR TreeFam; TF331157; -.
DR Proteomes; UP000002281; Chromosome 22.
DR Bgee; ENSECAG00000016998; Expressed in leukocyte and 23 other tissues.
DR ExpressionAtlas; Q3ZTK5; baseline.
DR GO; GO:0035631; C:CD40 receptor complex; IBA:GO_Central.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0042113; P:B cell activation; IBA:GO_Central.
DR GO; GO:0019724; P:B cell mediated immunity; IEA:Ensembl.
DR GO; GO:0042100; P:B cell proliferation; IEA:Ensembl.
DR GO; GO:0023035; P:CD40 signaling pathway; IBA:GO_Central.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0042832; P:defense response to protozoan; IBA:GO_Central.
DR GO; GO:0051607; P:defense response to virus; IBA:GO_Central.
DR GO; GO:0002768; P:immune response-regulating cell surface receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IBA:GO_Central.
DR GO; GO:0030890; P:positive regulation of B cell proliferation; IBA:GO_Central.
DR GO; GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IBA:GO_Central.
DR GO; GO:2000353; P:positive regulation of endothelial cell apoptotic process; IBA:GO_Central.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR GO; GO:0032735; P:positive regulation of interleukin-12 production; IBA:GO_Central.
DR GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; IBA:GO_Central.
DR GO; GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl.
DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IBA:GO_Central.
DR GO; GO:0090037; P:positive regulation of protein kinase C signaling; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IBA:GO_Central.
DR GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR GO; GO:0034341; P:response to interferon-gamma; IBA:GO_Central.
DR GO; GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; IBA:GO_Central.
DR CDD; cd13407; TNFRSF5; 1.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR020435; TNFR_5.
DR InterPro; IPR034021; TNFRSF5_N.
DR Pfam; PF00020; TNFR_c6; 1.
DR PRINTS; PR01922; TNFACTORR5.
DR SMART; SM00208; TNFR; 4.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 3.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunity; Membrane; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..280
FT /note="Tumor necrosis factor receptor superfamily member 5"
FT /id="PRO_0000252695"
FT TOPO_DOM 21..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..280
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 25..60
FT /note="TNFR-Cys 1"
FT REPEAT 61..103
FT /note="TNFR-Cys 2"
FT REPEAT 104..144
FT /note="TNFR-Cys 3"
FT REPEAT 145..187
FT /note="TNFR-Cys 4"
FT CARBOHYD 180
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 26..37
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 38..51
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 41..59
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 62..77
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 83..103
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 105..119
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 111..116
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 125..143
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 280 AA; 30279 MW; 1667919F81D60D68 CRC64;
MVRLPLQCLL WGCLLTPVHP EQATACKGNQ YLSGSHCCDL CPPGKKLVND CTGITETECS
PCGAGEFLDT WNRESRCHQH KYCDPNLGLQ VQGTGTSTTD ATCICHEGQH CSSDACESCI
LHSPCAPGLG VKQLATGVSD TVCEPCPVGF FSKVSSALEK CHPWTSCDTK GLVELQAGTN
KTDAVCGFRN RMRALVVIPI TMGVLFAVLL LSACIRKVAK EPENKALHRK VGWQDPVETV
YPDDFPGPHS IAPVQETLHG CQPVTQEDGK ESRISVQERQ
