ID   TNR5_STREE              Reviewed;         405 AA.
AC   P62905; P27451;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   31-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Transposase from transposon Tn1545;
DE   AltName: Full=Integrase;
GN   Name=int;
OS   Streptococcus pneumoniae.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1313;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TRANSPOSON=Tn1545;
RX   PubMed=2551683; DOI=10.1002/j.1460-2075.1989.tb08373.x;
RA   Poyart-Salmeron C., Trieu-Cuot P., Carlier C., Courvalin P.;
RT   "Molecular characterization of two proteins involved in the excision of the
RT   conjugative transposon Tn1545: homologies with other site-specific
RT   recombinases.";
RL   EMBO J. 8:2425-2433(1989).
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. {ECO:0000305}.
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DR   EMBL; X61025; CAA43360.1; -; Genomic_DNA.
DR   PIR; S05386; RSSOP5.
DR   RefSeq; WP_001291561.1; NZ_WNIA01000003.1.
DR   AlphaFoldDB; P62905; -.
DR   BMRB; P62905; -.
DR   SMR; P62905; -.
DR   GeneID; 58554906; -.
DR   GeneID; 61318952; -.
DR   GeneID; 64019861; -.
DR   GeneID; 8154822; -.
DR   OMA; FQLNTVI; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008907; F:integrase activity; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; -; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR016177; DNA-bd_dom_sf.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   InterPro; IPR004191; Integrase_Tn916-type_DNA-bd_N.
DR   Pfam; PF02920; Integrase_DNA; 1.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF54171; SSF54171; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   DNA integration; DNA recombination; DNA-binding; Transposable element;
KW   Viral genome integration; Virus entry into host cell.
FT   CHAIN           1..405
FT                   /note="Transposase from transposon Tn1545"
FT                   /id="PRO_0000197558"
FT   DOMAIN          79..163
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT   DOMAIN          186..392
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        225
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        264
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        343
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        346
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        369
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        379
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
SQ   SEQUENCE   405 AA;  47022 MW;  AE123561BF3DF6A3 CRC64;
     MSEKRRDNKG RILKTGESQR KDGRYLYKYI DSFGEPQFVY SWKLVATDRV PAGKRDCISL
     REKIAELQKD IHDGIDVVGK KMTLCQLYAK QNAQRPKVRK NTETGRKYLM DILKKDKLGV
     RSIDSIKPSD AKEWAIRMSE NGYAYQTINN YKRSLKASFY IAIQDDCVRK NPFDFQLKAV
     LDDDTVPKTV LTEEQEEKLL AFAKADKTYS KNYDEILILL KTGLRISEFG GLTLPDLDFE
     NRLVNIDHQL LRDTEIGYYI ETPKTKSGER QVPMVEEAYQ AFKRVLANRK NDKRVEIDGY
     SDFLFLNRKN YPKVASDYNG MMKGLVKKYN KYNEDKLPHI TPHSLRHTFC TNYANAGMNP
     KALQYIMGHA NIAMTLNYYA HATFDSAMAE MKRLNKEKQQ ERLVA