ID   TNR7_ENTFL              Reviewed;         184 AA.
AC   P06693;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2003, sequence version 3.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Transposon Tn917 resolvase;
GN   Name=tnpR;
OS   Enterococcus faecalis (Streptococcus faecalis).
OG   Plasmid pAD2.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=1351;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DS16; PLASMID=pAD2; TRANSPOSON=Tn917;
RX   PubMed=2997130; DOI=10.1128/jb.164.2.782-796.1985;
RA   Shaw J.H., Clewell D.B.;
RT   "Complete nucleotide sequence of macrolide-lincosamide-streptogramin B-
RT   resistance transposon Tn917 in Streptococcus faecalis.";
RL   J. Bacteriol. 164:782-796(1985).
RN   [2]
RP   SEQUENCE REVISION TO C-TERMINUS.
RA   Flannagan S.E., Clewell D.B.;
RL   Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Resolvase catalyzes the resolution (a site-specific
CC       recombination) of the cointegrated replicon to yield the final
CC       transposition products.
CC   -!- SIMILARITY: Belongs to the site-specific recombinase resolvase family.
CC       {ECO:0000305}.
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DR   EMBL; M11180; AAA27454.2; -; Genomic_DNA.
DR   PIR; D25028; D25028.
DR   RefSeq; WP_000576156.1; NZ_WVTO01000015.1.
DR   AlphaFoldDB; P06693; -.
DR   SMR; P06693; -.
DR   GeneID; 60887344; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000150; F:DNA strand exchange activity; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1390; -; 1.
DR   InterPro; IPR006118; Recombinase_CS.
DR   InterPro; IPR006119; Resolv_N.
DR   InterPro; IPR036162; Resolvase-like_N_sf.
DR   InterPro; IPR006120; Resolvase_HTH_dom.
DR   Pfam; PF02796; HTH_7; 1.
DR   Pfam; PF00239; Resolvase; 1.
DR   SMART; SM00857; Resolvase; 1.
DR   SUPFAM; SSF53041; SSF53041; 1.
DR   PROSITE; PS00397; RECOMBINASES_1; 1.
DR   PROSITE; PS00398; RECOMBINASES_2; 1.
DR   PROSITE; PS51736; RECOMBINASES_3; 1.
PE   3: Inferred from homology;
KW   DNA integration; DNA recombination; DNA-binding; Plasmid;
KW   Transposable element.
FT   CHAIN           1..184
FT                   /note="Transposon Tn917 resolvase"
FT                   /id="PRO_0000196375"
FT   DOMAIN          1..134
FT                   /note="Resolvase/invertase-type recombinase catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01072"
FT   DNA_BIND        161..180
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        9
FT                   /note="O-(5'-phospho-DNA)-serine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01072"
SQ   SEQUENCE   184 AA;  21094 MW;  472E48FA69ECB822 CRC64;
     MIFGYARVST DDQNLSLQID ALTHYGIDKL FQEKVTGAKK DRPQLEEMIN LLREGDSVVI
     YKLDRISRST KHLIELSELF EELSVNFISI QDNVDTSTSM GRFFFRVMAS LAELERDIII
     ERTNSGLKAA RVRGKKGGRP SKGKLSIDLA LKMYDSKEYS IRQILDASKL SKTTFYRYLN
     KRNA