TO20L_HUMAN
ID TO20L_HUMAN Reviewed; 152 AA.
AC Q6UXN7; B2RPR0;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=TOMM20-like protein 1;
GN Name=TOMM20L; ORFNames=UNQ9438/PRO34772;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q6UXN7; B3EWG5: FAM25C; NbExp=3; IntAct=EBI-11954062, EBI-14240149;
CC Q6UXN7; O43716: GATC; NbExp=3; IntAct=EBI-11954062, EBI-6929453;
CC Q6UXN7; O76064: RNF8; NbExp=3; IntAct=EBI-11954062, EBI-373337;
CC Q6UXN7; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-11954062, EBI-947187;
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000305};
CC Single-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Tom20 family. {ECO:0000305}.
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DR EMBL; AY358266; AAQ88633.1; -; mRNA.
DR EMBL; CH471061; EAW80733.1; -; Genomic_DNA.
DR EMBL; BC137557; AAI37558.1; -; mRNA.
DR EMBL; BC137563; AAI37564.1; -; mRNA.
DR CCDS; CCDS9734.1; -.
DR RefSeq; NP_997260.1; NM_207377.2.
DR AlphaFoldDB; Q6UXN7; -.
DR SMR; Q6UXN7; -.
DR BioGRID; 132529; 46.
DR IntAct; Q6UXN7; 6.
DR STRING; 9606.ENSP00000354204; -.
DR BioMuta; TOMM20L; -.
DR DMDM; 74738230; -.
DR MassIVE; Q6UXN7; -.
DR PaxDb; Q6UXN7; -.
DR PeptideAtlas; Q6UXN7; -.
DR PRIDE; Q6UXN7; -.
DR Antibodypedia; 51460; 66 antibodies from 14 providers.
DR DNASU; 387990; -.
DR Ensembl; ENST00000360945.7; ENSP00000354204.2; ENSG00000196860.8.
DR GeneID; 387990; -.
DR KEGG; hsa:387990; -.
DR MANE-Select; ENST00000360945.7; ENSP00000354204.2; NM_207377.3; NP_997260.1.
DR UCSC; uc001xdr.2; human.
DR CTD; 387990; -.
DR GeneCards; TOMM20L; -.
DR HGNC; HGNC:33752; TOMM20L.
DR HPA; ENSG00000196860; Tissue enriched (testis).
DR neXtProt; NX_Q6UXN7; -.
DR OpenTargets; ENSG00000196860; -.
DR PharmGKB; PA162406689; -.
DR VEuPathDB; HostDB:ENSG00000196860; -.
DR eggNOG; KOG4056; Eukaryota.
DR GeneTree; ENSGT00390000011698; -.
DR HOGENOM; CLU_100000_2_0_1; -.
DR InParanoid; Q6UXN7; -.
DR OMA; GYCIYLD; -.
DR OrthoDB; 1316067at2759; -.
DR PhylomeDB; Q6UXN7; -.
DR TreeFam; TF106200; -.
DR PathwayCommons; Q6UXN7; -.
DR SignaLink; Q6UXN7; -.
DR BioGRID-ORCS; 387990; 11 hits in 1066 CRISPR screens.
DR GenomeRNAi; 387990; -.
DR Pharos; Q6UXN7; Tdark.
DR PRO; PR:Q6UXN7; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q6UXN7; protein.
DR Bgee; ENSG00000196860; Expressed in left testis and 98 other tissues.
DR ExpressionAtlas; Q6UXN7; baseline and differential.
DR GO; GO:0031307; C:integral component of mitochondrial outer membrane; IBA:GO_Central.
DR GO; GO:0005742; C:mitochondrial outer membrane translocase complex; IBA:GO_Central.
DR GO; GO:0030943; F:mitochondrion targeting sequence binding; IBA:GO_Central.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR GO; GO:0016031; P:tRNA import into mitochondrion; IBA:GO_Central.
DR Gene3D; 1.20.960.10; -; 1.
DR InterPro; IPR002056; MAS20.
DR InterPro; IPR022422; MAS20_rcpt_metazoan.
DR InterPro; IPR023392; Tom20_dom_sf.
DR PANTHER; PTHR12430; PTHR12430; 1.
DR Pfam; PF02064; MAS20; 1.
DR PIRSF; PIRSF037707; MAS20_rcpt; 1.
DR PRINTS; PR01989; EUOM20RECPTR.
DR PRINTS; PR00351; OM20RECEPTOR.
DR SUPFAM; SSF47157; SSF47157; 1.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..152
FT /note="TOMM20-like protein 1"
FT /id="PRO_0000317747"
FT TOPO_DOM 1..9
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 10..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 30..152
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 43..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 152 AA; 17700 MW; 7B9EE302E86FB919 CRC64;
MPSVRSLLRL LAAAAACGAF AFLGYCIYLN RKRRGDPAFK RRLRDKRRAE PQKAEEQGTQ
LWDPTKNKKL QELFLQEVRM GELWLSRGEH RMGIQHLGNA LLVCEQPREL LKVFKHTLPP
KVFEMLLHKI PLICQQFEAD MNEQDCLEDD PD
