TO402_DROME
ID TO402_DROME Reviewed; 340 AA.
AC A1Z6L1; Q6NN68;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Mitochondrial import receptor subunit TOM40 homolog 2 {ECO:0000250|UniProtKB:Q75Q40, ECO:0000303|PubMed:15304338};
DE AltName: Full=Translocase of outer membrane 40 kDa subunit homolog 2;
GN Name=tomboy40 {ECO:0000312|FlyBase:FBgn0033074}; ORFNames=CG8330;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000312|EMBL:AAF57268.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAF57268.1}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:AAR96217.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Testis;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.;
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305}
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=15304338; DOI=10.1016/j.febslet.2004.07.025;
RA Hwa J.J., Zhu A.J., Hiller M.A., Kon C.Y., Fuller M.T., Santel A.;
RT "Germ-line specific variants of components of the mitochondrial outer
RT membrane import machinery in Drosophila.";
RL FEBS Lett. 572:141-146(2004).
CC -!- FUNCTION: Channel-forming protein essential for import of protein
CC precursors into mitochondria. {ECO:0000250|UniProtKB:Q75Q40}.
CC -!- SUBUNIT: Forms part of the preprotein translocase of the outer
CC mitochondrial membrane (TOM complex). Interacts with mitochondrial
CC targeting sequences (By similarity). {ECO:0000250|UniProtKB:Q75Q40}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC {ECO:0000269|PubMed:15304338}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:15304338}.
CC -!- TISSUE SPECIFICITY: Only expressed in the male germline, detected in
CC primary spermatocytes as well as post-meiotic stages. Not detected in
CC stem cells and spermatogonia near the tip of the testis.
CC {ECO:0000269|PubMed:15304338}.
CC -!- SIMILARITY: Belongs to the Tom40 family. {ECO:0000255}.
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DR EMBL; AE013599; AAF57268.1; -; Genomic_DNA.
DR EMBL; BT011425; AAR96217.1; -; mRNA.
DR RefSeq; NP_610213.1; NM_136369.2.
DR AlphaFoldDB; A1Z6L1; -.
DR SMR; A1Z6L1; -.
DR STRING; 7227.FBpp0085338; -.
DR PaxDb; A1Z6L1; -.
DR PRIDE; A1Z6L1; -.
DR DNASU; 35553; -.
DR EnsemblMetazoa; FBtr0085994; FBpp0085338; FBgn0033074.
DR GeneID; 35553; -.
DR KEGG; dme:Dmel_CG8330; -.
DR UCSC; CG8330-RA; d. melanogaster.
DR CTD; 35553; -.
DR FlyBase; FBgn0033074; tomboy40.
DR VEuPathDB; VectorBase:FBgn0033074; -.
DR eggNOG; KOG3296; Eukaryota.
DR HOGENOM; CLU_054399_0_0_1; -.
DR InParanoid; A1Z6L1; -.
DR OMA; ISGRMNH; -.
DR OrthoDB; 1346842at2759; -.
DR PhylomeDB; A1Z6L1; -.
DR BioGRID-ORCS; 35553; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 35553; -.
DR PRO; PR:A1Z6L1; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0033074; Expressed in testis and 12 other tissues.
DR ExpressionAtlas; A1Z6L1; baseline and differential.
DR Genevisible; A1Z6L1; DM.
DR GO; GO:0042719; C:mitochondrial intermembrane space protein transporter complex; IDA:UniProtKB.
DR GO; GO:0005742; C:mitochondrial outer membrane translocase complex; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IDA:FlyBase.
DR GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR GO; GO:0008320; F:protein transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR GO; GO:0006626; P:protein targeting to mitochondrion; ISS:UniProtKB.
DR CDD; cd07305; Porin3_Tom40; 1.
DR Gene3D; 2.40.160.10; -; 1.
DR InterPro; IPR023614; Porin_dom_sf.
DR InterPro; IPR027246; Porin_Euk/Tom40.
DR InterPro; IPR037930; Tom40.
DR PANTHER; PTHR10802; PTHR10802; 1.
DR Pfam; PF01459; Porin_3; 1.
PE 2: Evidence at transcript level;
KW Ion transport; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW Porin; Protein transport; Reference proteome; Transmembrane;
KW Transmembrane beta strand; Transport.
FT CHAIN 1..340
FT /note="Mitochondrial import receptor subunit TOM40 homolog
FT 2"
FT /id="PRO_0000355096"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 27
FT /note="P -> A (in Ref. 3; AAR96217)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 340 AA; 36983 MW; 14CBEDE0C3A43B86 CRC64;
MGNVMASTAD AESSRGRGHL SAGLRLPEAP QYSGGVPPQM VEALKAEAKK PELTNPGTLE
ELHSRCRDIQ ANTFEGAKIM VNKGLSNHFQ VTHTINMNSA GPSGYRFGAT YVGTKQYGPT
EAFPVLLGEI DPMGNLNANV IHQLTSRLRC KFASQFQDSK LVGTQLTGDY RGRDYTLTLT
MGNPGFFTSS GVFVCQYLQS VTKRLALGSE FAYHYGPNVP GRQVAVLSAV GRYAFGDTVW
SCTLGPAGFH LSYYQKASDQ LQIGVEVETN IRQQESTATV AYQIDLPKAD LVFRGSLDSN
WLISGVLEKR LQPLPFSLAI SGRMNHQKNS FRLGCGLMIG
