ID   TO4AA_XENLA             Reviewed;         420 AA.
AC   Q0IHC5;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Torsin-4A-A;
DE   AltName: Full=Torsin family 4 member A-A;
GN   Name=tor4a-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Fat body;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ClpA/ClpB family. Torsin subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC123214; AAI23215.1; -; mRNA.
DR   RefSeq; NP_001090348.1; NM_001096879.1.
DR   RefSeq; XP_018087649.1; XM_018232160.1.
DR   AlphaFoldDB; Q0IHC5; -.
DR   SMR; Q0IHC5; -.
DR   DNASU; 779258; -.
DR   GeneID; 779258; -.
DR   KEGG; xla:779258; -.
DR   CTD; 779258; -.
DR   Xenbase; XB-GENE-975365; tor4a.S.
DR   OMA; MRIKQKY; -.
DR   OrthoDB; 757464at2759; -.
DR   Proteomes; UP000186698; Chromosome 8S.
DR   Bgee; 779258; Expressed in lung and 15 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010448; Torsin.
DR   InterPro; IPR030551; Torsin-4A.
DR   PANTHER; PTHR10760; PTHR10760; 1.
DR   PANTHER; PTHR10760:SF1; PTHR10760:SF1; 1.
DR   Pfam; PF06309; Torsin; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..420
FT                   /note="Torsin-4A-A"
FT                   /id="PRO_0000287492"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         202..209
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   420 AA;  48495 MW;  E9159DB2E3A64DAD CRC64;
     MEETESSTQT PVPQHGISLA SYPVRAVIRM RRKIRTLKKS RLQLDLTGGR SLDSAKASLR
     RQISMDRATL FKSSTYEKQQ YFNFDTPTLE KLALNSQIRK RNRKKSRHVL YPGNVRKCLP
     VEHKSKAKRC LLLFIGIVCF QILNAIENLD DNLQKYDLDG LEKTLQREVF GQKRAIEKLM
     DHLQDYLATH YHNKPLVLSF NGPSGVGKSH TGRLLAKHFR SIMDNDFVLQ YYTMHNCPNE
     NDVTQCQSEM SGLISEMISR AEIEEKIPVF IFDEVEVMPV ALLDVLHRYF QLNQSNEYLN
     AVYILISNIG GNEITKFVLQ NASNDFLNLP QELHQIVISS LQKHHSLWDV AEIVPFTLLE
     KKHILDCFLD ELLREGFYPD HSNIESLAGQ LRYYTKENKE YSISGCKQVV AKVNLLQPYT